Search Results - "Alzheimer Disease metabolism"

Early metabolic changes in the brain of Alzheimer’s disease rats are driven by GLAST+ cells

Authors: Morrey, William J Ceyzeriat, Kelly Amosse, Quentin et al.

Source: J Cereb Blood Flow Metab
Journal of cerebral blood flow and metabolism, vol. 45, no. 7, pp. 1326-1342
Morrey, W J, Ceyzériat, K, Amossé, Q, Badina, A M, Dickie, B, Schiessl, I, Tsartsalis, S, Millet, P, Boutin, H & Tournier, B B 2025, 'Early metabolic changes in the brain of Alzheimer's disease rats are driven by GLAST+ cells', Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X251318923

Subject Terms: Brain metabolism, Animals, Alzheimer Disease/metabolism, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/pathology, Male, Rats, Positron-Emission Tomography, Fluorodeoxyglucose F18, Brain/metabolism, Brain/diagnostic imaging, Rats, Inbred F344, Glucose/metabolism, Monocarboxylic Acid Transporters/metabolism, Disease Models, Animal, Alzheimer's disease, FDG-PET, MACS-RTT, astrocyte-neurone lactate shuttle, brain metabolism, 616.89, Original Article, Astrocyte-neurone lactate shuttle

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39917849
https://archive-ouverte.unige.ch/unige:183292
https://doi.org/10.1177/0271678x251318923
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_23594C0E9CE34
https://serval.unil.ch/notice/serval:BIB_23594C0E9CE3
https://serval.unil.ch/resource/serval:BIB_23594C0E9CE3.P001/REF.pdf

Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis

Authors: Yixun Su Hui Li Wenjie Zhang et al.

Source: Nat Commun
Su, Y, Li, H, Zhang, W, Tao, S, Wang, Q, Zhang, X, Zhou, M, Huang, X, Wang, C, Tang, Y, Chen, H, Verkhratsky, A, Zha, Z, Niu, J & Yi, C 2025, 'Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis', Nature Communications, vol. 16, no. 1, pp. 5621. https://doi.org/10.1038/s41467-025-60746-w

Subject Terms: Mice, Knockout, Male, Animal, Knockout, Mice, Transgenic, Cognitive Dysfunction/metabolism, Transgenic, Neuroprotection, Presenilin-1/genetics, Article, Microglia/metabolism, Disease Models, Animal, Mice, Disease Models, Animals, Humans, Alzheimer Disease/metabolism, Female, Amyloidosis/metabolism, Plaque, Amyloid/pathology, Connexin 43/metabolism, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Peptides/metabolism, Plaque, Amyloid/pathology

Access URL: https://research.manchester.ac.uk/en/publications/bbd0c939-1f08-4aff-b3e9-497fcae15874
https://doi.org/10.1038/s41467-025-60746-w

Untangling the role of tau in sex hormone responsive cancers: lessons learnt from Alzheimer's disease

Authors: Rachel M. Barker Alfie Chambers Patrick G. Kehoe et al.

Source: Clin Sci (Lond)

Subject Terms: Male, Neoplasms, Hormone-Dependent, Breast Neoplasms, tau Proteins, Hormone-Dependent/metabolism, Phosphatidylinositol 3-Kinases, tau Proteins/metabolism, Breast Neoplasms/drug therapy, Alzheimer Disease, Signal Transduction/drug effects, Neoplasms, Proto-Oncogene Proteins c-akt/metabolism, Animals, Humans, Alzheimer Disease/metabolism, Female, Gonadal Steroid Hormones/metabolism, Phosphatidylinositol 3-Kinases/metabolism, Gonadal Steroid Hormones, Proto-Oncogene Proteins c-akt, Neoplasms/metabolism, Cancer, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/39469929

Glucose metabolism in hyper-connected regions predicts neurodegeneration and speed of conversion in Alzheimer's disease.

Authors: Galli, Alice Inglese, Marianna Presotto, Luca et al.

Source: European Journal of Nuclear Medicine and Molecular Imaging, 52 (12), 4639 - 4651 (2025-10)

Subject Terms: Glucose metabolism, Graph theory, Hyper-connectivity, Hypo-connectivity, Mild cognitive impairment, Prodromal, Glucose, Fluorodeoxyglucose F18, Humans, Male, Female, Aged, Positron-Emission Tomography, Disease Progression, Longitudinal Studies, Cognitive Dysfunction/metabolism, Cognitive Dysfunction/diagnostic imaging, Middle Aged, Aged, 80 and over, Alzheimer Disease/metabolism, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/pathology, Glucose/metabolism, Brain/metabolism, Brain/diagnostic imaging, Alzheimer, Clustering analysis, Cognitive impairment, Connected region, Neurodegeneration, Alzheimer Disease, Brain, Cognitive Dysfunction, Radiology, Nuclear Medicine and Imaging, Human health sciences, Radiology, nuclear medicine & imaging, Sciences de la santé humaine, Radiologie, médecine & imagerie nucléaire

Relation: https://link.springer.com/content/pdf/10.1007/s00259-025-07379-9.pdf; urn:issn:1619-7070; urn:issn:1619-7089

Access URL: https://orbi.uliege.be/handle/2268/337117

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

Authors: Victoria Gomez-Murcia Agathe Launay Kévin Carvalho et al.

Contributors: Victoria Gomez-Murcia Agathe Launay Kévin Carvalho et al.

Source: Brain
Brain, vol. 147, no. 8, pp. 2691-2705

Subject Terms: Male, 0301 basic medicine, Receptor, Adenosine A2A, Mice, Transgenic, Plaque, Amyloid, A(2A) receptor, Hippocampus, Animals, Memory Disorders/metabolism, Memory Disorders/genetics, Memory Disorders/pathology, Mice, Receptor, Adenosine A2A/metabolism, Receptor, Adenosine A2A/genetics, Synapses/metabolism, Synapses/pathology, Amyloid beta-Protein Precursor/genetics, Amyloid beta-Protein Precursor/metabolism, Neurons/metabolism, Neurons/pathology, Alzheimer Disease/metabolism, Alzheimer Disease/pathology, Alzheimer Disease/genetics, Hippocampus/metabolism, Hippocampus/pathology, Presenilin-1/genetics, Disease Models, Animal, Plaque, Amyloid/pathology, Plaque, Amyloid/metabolism, Mice, Inbred C57BL, A2A receptor, Alzheimer's disease, Synapse loss, adenosine, Amyloid beta-Protein Precursor, 03 medical and health sciences, Alzheimer Disease, Presenilin-1, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurons, Memory Disorders, 0303 health sciences, 3. Good health, [SDV] Life Sciences [q-bio], Synapses, Original Article

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Access URL: https://pubmed.ncbi.nlm.nih.gov/38964748
https://hal.univ-lille.fr/hal-04684882v1/document
https://hal.univ-lille.fr/hal-04684882v1
https://doi.org/10.1093/brain/awae113
https://serval.unil.ch/resource/serval:BIB_58B757DC2950.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_58B757DC2950
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_58B757DC29503

Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer's disease

Authors: Ercan, Huriye Reumiller, Christina Maria Mühlberger, Jacqueline et al.

Source: Alzheimers Dement

Subject Terms: Blood Platelets, Male, Proteomics, Glutathione Transferase Metabolism, Alzheimer Disease Metabolism, Glutathione Peroxidase Metabolism, Alzheimer Disease Blood, Cognitive Dysfunction Blood, Superoxide Dismutase-1 Metabolism, Biomarkers Blood, Polymorphism, Single Nucleotide, Antioxidants, Superoxide Dismutase-1, Glutathione Peroxidase GPX1, Glutathione Peroxidase Blood, Alzheimer Disease, Polymorphism, Single Nucleotide Genetics, Humans, Cognitive Dysfunction, Aged, Glutathione Transferase, Aged, 80 and over, Glutathione Peroxidase, Superoxide Dismutase Metabolism, Blood Platelets Metabolism, Superoxide Dismutase, Cognitive Dysfunction Metabolism, Frontal Lobe Metabolism, Antioxidants Metabolism, Frontal Lobe, Alzheimer Disease Pathology, Female, Alzheimer Disease Genetics, Biomarkers, Research Article

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Access URL: https://pubmed.ncbi.nlm.nih.gov/40189792
https://phaidra.vetmeduni.ac.at/o:4077
https://doi.org/10.1002/alz.70117

Dopaminergic deficits along the spectrum of Alzheimer's disease.

Authors: Pilotto, Andrea Galli, Alice Sala, Arianna et al.

Source: Molecular Psychiatry, 30 (7), 3069 - 3076 (2025-07)

Subject Terms: Dopamine, Dopamine Plasma Membrane Transport Proteins, Tropanes, 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane, Humans, Male, Female, Aged, Brain/metabolism, Brain/diagnostic imaging, Tomography, Emission-Computed, Single-Photon/methods, Dopamine Plasma Membrane Transport Proteins/metabolism, Aged, 80 and over, Cognitive Dysfunction/metabolism, Middle Aged, Neural Pathways/metabolism, Alzheimer Disease/metabolism, Alzheimer Disease/diagnostic imaging, Dopamine/metabolism, Alzheimer Disease, Brain, Cognitive Dysfunction, Neural Pathways, Tomography, Emission-Computed, Single-Photon, Molecular Biology, Cellular and Molecular Neuroscience, Psychiatry and Mental Health, Human health sciences, Neurology, Sciences de la santé humaine, Neurologie

Relation: https://www.nature.com/articles/s41380-025-02913-5.pdf; urn:issn:1359-4184; urn:issn:1476-5578

Access URL: https://orbi.uliege.be/handle/2268/337116

Assessment of [18F]PI-2620 Tau-PET Quantification via Non-Invasive Automatized Image Derived Input Function

Authors: Meindl, Maria Zatcepin, Artem Gnörich, Johannes et al.

Source: Eur J Nucl Med Mol Imaging
European journal of nuclear medicine and molecular imaging 51(11), 3252-3266 (2024). doi:10.1007/s00259-024-06741-7

Subject Terms: Male, Female [MeSH], Aged [MeSH], Radiopharmaceuticals/pharmacokinetics [MeSH], Humans [MeSH], Supranuclear Palsy, Progressive/diagnostic imaging [MeSH], Alzheimer Disease/diagnostic imaging [MeSH], Four-repeat tauopathies, Middle Aged [MeSH], Supranuclear Palsy, Progressive/metabolism [MeSH], Alzheimer's disease, Image Processing, Computer-Assisted/methods [MeSH], Original Article, Positron-Emission Tomography/methods [MeSH], Male [MeSH], Tau, Image derived input function, Automation [MeSH], Case-Control Studies [MeSH], Alzheimer Disease/metabolism [MeSH], [, tau Proteins/metabolism [MeSH], tau Proteins, metabolism [Supranuclear Palsy, Progressive], Automation, Alzheimer Disease, methods [Image Processing, Computer-Assisted], Image Processing, Computer-Assisted, Humans, ddc:610, diagnostic imaging [Supranuclear Palsy, Progressive], Aged, methods [Positron-Emission Tomography], Middle Aged, metabolism [tau Proteins], pharmacokinetics [Radiopharmaceuticals], ddc, 3. Good health, [18F]PI-2620 quantification, Positron-Emission Tomography, Case-Control Studies, Female, Supranuclear Palsy, Progressive, Radiopharmaceuticals, diagnostic imaging [Alzheimer Disease], metabolism [Alzheimer Disease]

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Access URL: https://pubmed.ncbi.nlm.nih.gov/38717592
https://repository.publisso.de/resource/frl:6509121
https://epub.ub.uni-muenchen.de/117792/
https://mediatum.ub.tum.de/1770913

Sex differences in the association of Alzheimer’s disease biomarkers and cognition in a multicenter memory clinic study

Authors: Boccalini, Cecilia Peretti, Debora Elisa Scheffler, Max et al.

Source: Alzheimers Res Ther
Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-11 (2025)
Alzheimer's research & therapy, vol. 17, no. 1, pp. 46
ALZHEIMERS RESEARCH & THERAPY, 17 (1)

Subject Terms: Male, tau-PET, Humans, Female, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/metabolism, Alzheimer Disease/psychology, Biomarkers/blood, Biomarkers/metabolism, Aged, tau Proteins/metabolism, Sex Characteristics, Cognition/physiology, Glial Fibrillary Acidic Protein/blood, Magnetic Resonance Imaging, Positron-Emission Tomography, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/metabolism, Aged, 80 and over, Amyloid beta-Peptides/metabolism, Middle Aged, Sex Factors, Alzheimer's disease, Biomarkers, Neuroimaging, Sex, Women, Neurosciences. Biological psychiatry. Neuropsychiatry, tau Proteins, Neuropsychological Tests, Cognition, Alzheimer Disease, Glial Fibrillary Acidic Protein, Cognitive Dysfunction, RC346-429, Amyloid beta-Peptides, Research, Neurology. Diseases of the nervous system, RC321-571

File Description: application/pdf; application/application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39966925
https://doaj.org/article/ad1d015d9d584c47bfd2d0613b074491
https://serval.unil.ch/notice/serval:BIB_38E2DE99CC3C
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_38E2DE99CC3C9
https://serval.unil.ch/resource/serval:BIB_38E2DE99CC3C.P001/REF.pdf
http://hdl.handle.net/20.500.11850/724750

Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway

Authors: Sabrina Petralla Liudmila Saveleva Katja M. Kanninen et al.

Source: Mol Neurobiol

Subject Terms: Cerebral Cortex, Inflammation, 0301 basic medicine, 0303 health sciences, Amyloid beta-Peptides, Brain cortex, Oxidative Stress [MeSH], Alzheimer's disease, Mice, Transgenic [MeSH], Microvessels/pathology [MeSH], 5xFAD mice, Alzheimer Disease/metabolism [MeSH], Disease Models, Animal [MeSH], Transferrin receptor, Female [MeSH], Cerebral Cortex/metabolism [MeSH], Cerebral Cortex/pathology [MeSH], Amyloid beta-Peptides/metabolism [MeSH], Animals [MeSH], Receptors, Transferrin/metabolism [MeSH], Brain microvessels, Peptide Fragments [MeSH], Mice [MeSH], Article, Microvessels/metabolism [MeSH], Inflammation/pathology [MeSH], Inflammation/metabolism [MeSH], Hypoxia-Inducible Factor 1, alpha Subunit/metabolism [MeSH], Signal Transduction [MeSH], HIF-1, Hypoxia-Inducible Factor 1/metabolism [MeSH], Alzheimer Disease/pathology [MeSH], Mice, Transgenic, Hypoxia-Inducible Factor 1, alpha Subunit, Peptide Fragments, Disease Models, Animal, Oxidative Stress, Mice, 03 medical and health sciences, Alzheimer Disease, Receptors, Transferrin, Microvessels, Animals, Female, Hypoxia-Inducible Factor 1, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/38296900
https://repository.publisso.de/resource/frl:6522172

Florbetapir PET-assessed demyelination is associated with faster tau accumulation in an APOE ε4-dependent manner

Authors: Rubinski, Anna Dewenter, Anna Zheng, Lukai et al.

Source: Eur J Nucl Med Mol Imaging
European journal of nuclear medicine and molecular imaging 51(4), 1035-1049 (2024). doi:10.1007/s00259-023-06530-8
European Journal of Nuclear Medicine and Molecular Imaging, vol 51, iss 4

Subject Terms: Florbetapir-PET, Aging, Apolipoprotein E4, Clinical sciences, genetics [Alzheimer Disease], Neurodegenerative, Alzheimer's Disease, metabolism [Cognitive Dysfunction], 2.1 Biological and endogenous factors, genetics [Apolipoprotein E4], Aniline Compounds, Original Article, Myelin, Tau, APOE, Medical and Health Sciences, Brain, 16. Peace & justice, ddc, Other Physical Sciences, Nuclear Medicine & Medical Imaging, Neurological, Cognitive Dysfunction/metabolism [MeSH], Demyelinating Diseases/metabolism [MeSH], Amyloid beta-Peptides/metabolism [MeSH], Humans [MeSH], Aniline Compounds [MeSH], Alzheimer Disease/diagnostic imaging [MeSH], Brain/metabolism [MeSH], Ethylene Glycols [MeSH], Apolipoproteins E [MeSH], Positron-Emission Tomography [MeSH], Alzheimer Disease/genetics [MeSH], Apolipoprotein E4/genetics [MeSH], Alzheimer Disease/metabolism [MeSH], tau Proteins/metabolism [MeSH], Biomedical Imaging, metabolism [Demyelinating Diseases], florbetapir, Ethylene Glycols, metabolism [Alzheimer Disease], Clinical Sciences, metabolism [Amyloid beta-Peptides], tau Proteins, Apolipoproteins E, Clinical Research, Alzheimer Disease, Acquired Cognitive Impairment, Humans, Cognitive Dysfunction, ddc:610, Amyloid beta-Peptides, Biomedical and Clinical Sciences, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease Neuroimaging Initiative, metabolism [tau Proteins], Brain Disorders, 4.1 Discovery and preclinical testing of markers and technologies, metabolism [Brain], Positron-Emission Tomography, Dementia, diagnostic imaging [Alzheimer Disease], Demyelinating Diseases

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38049659
https://pub.dzne.de/record/268319
https://repository.publisso.de/resource/frl:6502115
https://epub.ub.uni-muenchen.de/116314/
https://escholarship.org/uc/item/5r36q7bq
https://escholarship.org/content/qt5r36q7bq/qt5r36q7bq.pdf
https://mediatum.ub.tum.de/1764144

Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission

Authors: Stockbauer, Anna Beyer, Leonie Huber, Maria et al.

Contributors: Stockbauer, Anna Beyer, Leonie Huber, Maria et al.

Source: Eur J Nucl Med Mol Imaging
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Stockbauer, A, Beyer, L, Huber, M, Kreuzer, A, Palleis, C, Katzdobler, S, Rauchmann, B-S, Morbelli, S, Chincarini, A, Bruffaerts, R, Vandenberghe, R, Kramberger, M G, Trost, M, Garibotto, V, Nicastro, N, Lathuilière, A, Lemstra, A W, van Berckel, B N M, Pilotto, A, Padovani, A, Ochoa-Figueroa, M A, Davidsson, A, Camacho, V, Peira, E, Bauckneht, M, Pardini, M, Sambuceti, G, Aarsland, D, Nobili, F, Gross, M, Vöglein, J, Perneczky, R, Pogarell, O, Buerger, K, Franzmeier, N, Danek, A, Levin, J, Höglinger, G N U, Bartenstein, P, Cumming, P, Rominger, A & Brendel, M 2023, 'Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission', European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-023-06493-w
European journal of nuclear medicine and molecular imaging 51(4), 1023-1034 (2024). doi:10.1007/s00259-023-06493-w
European journal of nuclear medicine and molecular imaging
Stockbauer, Anna; Beyer, Leonie; Huber, Maria; Kreuzer, Annika; Palleis, Carla; Katzdobler, Sabrina; Rauchmann, Boris-Stephan; Morbelli, Silvia; Chincarini, Andrea; Bruffaerts, Rose; Vandenberghe, Rik; Kramberger, Milica G; Trost, Maja; Garibotto, Valentina; Nicastro, Nicolas; Lathuilière, Aurélien; Lemstra, Afina W; van Berckel, Bart N M; Pilotto, Andrea; Padovani, Alessandro; ... (2024). Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission. European journal of nuclear medicine and molecular imaging, 51(4), pp. 1023-1034. Springer 10.1007/s00259-023-06493-w <http://dx.doi.org/10.1007/s00259-023-06493-w>

Subject Terms: EXPRESSION, Lewy Body Disease, 616.8, DIAGNOSTIC-CRITERIA, 0299 Other Physical Sciences, Dopamine, Dementia with Lewy bodies, 610 Medicine & health, 618.97, Metabolic connectivity, Fluorodeoxyglucose F18, Alzheimer Disease, Humans, ddc:610, metabolism [Dopamine], FDG-PET, Biology, Science & Technology, 616.0757, diagnostic imaging [Lewy Body Disease], Radiology, Nuclear Medicine & Medical Imaging, Neurosciences, 1103 Clinical Sciences, DaT-Scan, 3. Good health, ALZHEIMERS-DISEASE, Nuclear Medicine & Medical Imaging, PET, metabolism [Glucose], Glucose, PRODROMAL DEMENTIA, 616.89, Positron-Emission Tomography, Original Article, Humans [MeSH], Lewy Body Disease/diagnostic imaging [MeSH], Fluorodeoxyglucose F18 [MeSH], Dopamine/metabolism [MeSH], Metabolic Networks and Pathways [MeSH], Positron-Emission Tomography [MeSH], Alzheimer Disease/metabolism [MeSH], Glucose/metabolism [MeSH], Human medicine, Life Sciences & Biomedicine, Neurovetenskaper, metabolism [Alzheimer Disease], Metabolic Networks and Pathways

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/37971501
https://research.vumc.nl/en/publications/d816c8f4-6fd1-4b58-80ce-02c42dffd2c0
https://pub.dzne.de/record/268317
https://pure.amsterdamumc.nl/en/publications/0ca7faf0-c686-499f-b16f-8d066ed4a724
https://doi.org/10.1007/s00259-023-06493-w
https://archive-ouverte.unige.ch/unige:174082
https://doi.org/10.1007/s00259-023-06493-w
https://hdl.handle.net/10067/2028590151162165141
https://repository.uantwerpen.be/docstore/d:irua:21845
https://boris.unibe.ch/189129/
https://repository.publisso.de/resource/frl:6524430
http://hdl.handle.net/1942/42290
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200526
https://epub.ub.uni-muenchen.de/116446/

N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease

Authors: Marko Jörg Johanna E. Plehn Marco Kristen et al.

Contributors: Marko Jörg Johanna E. Plehn Marco Kristen et al.

Source: Mol Psychiatry

Subject Terms: Male, Aged, 80 and over, 540 Chemistry and allied sciences, Adenosine, Electron Transport Complex I, Amyloid beta-Peptides, 610 Medizin, Methyltransferases, Methylation, Article, Mitochondria, Mitochondrial Proteins, Alzheimer Disease, 540 Chemie, 610 Medical sciences, Humans, Aged, 80 and over [MeSH], Aged [MeSH], Adenosine/metabolism [MeSH], 38/90, 692/699/476, 96/109, Electron Transport Complex I/genetics [MeSH], Male [MeSH], Mitochondrial Proteins/genetics [MeSH], 82/58, Alzheimer Disease/metabolism [MeSH], RNA, Messenger/metabolism [MeSH], 13/89, Female [MeSH], Mitochondrial Proteins/metabolism [MeSH], 82/80, Methylation [MeSH], Mitochondria/metabolism [MeSH], Amyloid beta-Peptides/metabolism [MeSH], Humans [MeSH], Electron Transport Complex I/metabolism [MeSH], 631/45, 38/71, Methyltransferases/genetics [MeSH], Alzheimer Disease/genetics [MeSH], Methyltransferases/metabolism [MeSH], article, Female, RNA, Messenger, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/38287100
https://repository.publisso.de/resource/frl:6504569

The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

Authors: Naif H. Ali Hayder M. Al‐kuraishy Ali I. Al‐Gareeb et al.

Source: Acta Neurol Belg

Subject Terms: Cancer Research, S100 Proteins: Structure, Function, and Pathology, Physiology, Immunology, Neuroserpin, Plasmin, Plasminogen activator, Review Article, Pathogenesis, Biochemistry, Mechanisms of Alzheimer's Disease, Endocrinology, Alzheimer Disease, Biochemistry, Genetics and Molecular Biology, Plasminogen Activator Inhibitor 1, Health Sciences, TREM2, Humans, Disease, Fibrinolysin, Neurodegeneration, Molecular Biology, Biology, Internal medicine, Role of Matrix Metalloproteinases in Cancer and Physiology, Neuropathology, Pharmacology, Inflammation, Tissue plasminogen activator, Amyloid beta-Peptides, FOS: Clinical medicine, Life Sciences, Plasminogen, Alzheimer's disease, Neuroprotection, 3. Good health, Chemistry, Plasminogen Activator Inhibitor 1 [MeSH], Amyloid beta-Peptides/metabolism [MeSH], Humans [MeSH], Amyloid beta, Tissue Plasminogen Activator [MeSH], Fibrinolysin/metabolism [MeSH], Neuroserpin [MeSH], Alzheimer Disease/metabolism [MeSH], Plasminogen/metabolism [MeSH], Tissue plasminogen activators, Enzyme, Tissue Plasminogen Activator, FOS: Biological sciences, Medicine, Microglia, Neuroscience

Access URL: https://pubmed.ncbi.nlm.nih.gov/37917293
https://repository.publisso.de/resource/frl:6492739

Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer’s disease

Authors: Miao Zhang Xiao-hang Qian Jialin Hu et al.

Source: Eur J Nucl Med Mol Imaging
Zhang, Miao; Qian, Xiao-Hang; Hu, Jialin; Zhang, Yaoyu; Lin, Xiaozhu; Hai, Wangxi; Shi, Kuangyu; Jiang, Xufeng; Li, Yao; Tang, Hui-Dong; Li, Biao (2024). Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease. European journal of nuclear medicine and molecular imaging, 51(2), pp. 455-467. Springer 10.1007/s00259-023-06446-3 <http://dx.doi.org/10.1007/s00259-023-06446-3>

Subject Terms: Neuroinflammation, Amyloid beta-Peptides/metabolism [MeSH], Humans [MeSH], Prospective Studies [MeSH], TSPO, Alzheimer Disease/diagnostic imaging [MeSH], Neuroinflammatory Diseases [MeSH], Alzheimer's disease, Original Article, Positron-Emission Tomography/methods [MeSH], Receptors, GABA/metabolism [MeSH], Alzheimer Disease/genetics [MeSH], Alzheimer Disease/metabolism [MeSH], Gene Expression Profiling [MeSH], [, Receptors, GABA/genetics [MeSH], Amyloid-β, Amyloid beta-Peptides, Receptors, GABA, Alzheimer Disease, Gene Expression Profiling, Positron-Emission Tomography, Neuroinflammatory Diseases, Humans, 610 Medicine & health, Prospective Studies, 3. Good health, ddc

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/37801139
https://boris.unibe.ch/186963/
https://repository.publisso.de/resource/frl:6505509
https://mediatum.ub.tum.de/doc/1769832/document.pdf

Involvement of the choroid plexus in Alzheimer’s disease pathophysiology: findings from mouse and human proteomic studies: findings from mouse and human proteomic studies

Authors: Delvenne, Aurore Vandendriessche, Charysse Gobom, Johan et al.

Contributors: Delvenne, Aurore Vandendriessche, Charysse Gobom, Johan et al.

Source: Fluids Barriers CNS
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-17 (2024)
Delvenne, A, Vandendriessche, C, Gobom, J, Burgelman, M, Dujardin, P, de Nolf, C, Tijms, B M, Teunissen, C E, Schindler, S E, Verhey, F, Ramakers, I, Martinez-Lage, P, Tainta, M, Vandenberghe, R, Schaeverbeke, J, Engelborghs, S, de Roeck, E, Popp, J, Peyratout, G, Tsolaki, M, Freund-Levi, Y, Lovestone, S, Streffer, J, Bertram, L, Blennow, K, Zetterberg, H, Visser, P J, Vandenbroucke, R E & Vos, S J B 2024, 'Involvement of the choroid plexus in Alzheimer’s disease pathophysiology : findings from mouse and human proteomic studies', FLUIDS AND BARRIERS OF THE CNS, vol. 21, no. 1, 58. https://doi.org/10.1186/s12987-024-00555-3
Fluids and barriers of the CNS, vol. 21, no. 1, pp. 58
Fluids and barriers of the CNS
Fluids and barriers of the CNS, 21(1):58
FLUIDS AND BARRIERS OF THE CNS

Subject Terms: Proteomics, Male, Neurologi, Proteome, Proteome/metabolism, Choroid plexus, Amyloid-beta (A beta), Mice, Amyloid beta-Protein Precursor, VESSELS, Medicine and Health Sciences, Amyloid-β (Aβ), Choroid Plexus/metabolism, 11 Medical and Health Sciences, Amyloid beta-Protein Precursor/metabolism, Alzheimer's disease, 3. Good health, Cerebrospinal fluid, Neurology, Choroid Plexus/metabolism [MeSH], Female [MeSH], Amyloid beta-Protein Precursor/metabolism [MeSH], Mice, Inbred C57BL [MeSH], Proteomics [MeSH], Humans [MeSH], Animals [MeSH], Mice, Transgenic [MeSH], Mice [MeSH], Proteome/metabolism [MeSH], Male [MeSH], Research, Amyloid beta-Protein Precursor/genetics [MeSH], APP knock-in mice, Alzheimer Disease/metabolism [MeSH], Disease Models, Animal [MeSH], Alzheimer Disease/cerebrospinal fluid [MeSH], Alzheimer Disease/metabolism, Female, Life Sciences & Biomedicine, EXPRESSION, mice, Mice, Transgenic, Alzheimer Disease/cerebrospinal fluid, Animals, Humans, Disease Models, Animal, Amyloid beta-Protein Precursor/genetics, Mice, Inbred C57BL, proteomics, ADULT, Alzheimer Disease, RC346-429, CEREBROSPINAL-FLUID PRODUCTION, Science & Technology, Neurosciences, Biology and Life Sciences, 06 Biological Sciences, BARRIER, TRANSPORT, MODEL, 3209 Neurosciences, Choroid Plexus, Human medicine, Neurosciences & Neurology, Neurology. Diseases of the nervous system

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Access URL: https://pubmed.ncbi.nlm.nih.gov/39020361
https://doaj.org/article/7c5db71c472645af80c01089faaa997c
https://research.vumc.nl/en/publications/4ebbb5b9-aad9-46a1-9dd6-15f4f2ba65ce
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_AA3F1D78EAA61
https://serval.unil.ch/resource/serval:BIB_AA3F1D78EAA6.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_AA3F1D78EAA6
https://repository.uantwerpen.be/docstore/d:irua:25008
https://hdl.handle.net/10067/2077110151162165141
https://repository.publisso.de/resource/frl:6502664
https://biblio.vub.ac.be/vubir/(c5b30523-9aee-4776-ac0b-e58c8aaceabf).html
https://biblio.ugent.be/publication/01J73Q3F0X36FE71EVFSQ5Q591/file/01J73QE2PV3X1NSY0FF7P9T9GT
http://doi.org/10.1186/s12987-024-00555-3
https://biblio.ugent.be/publication/01J73Q3F0X36FE71EVFSQ5Q591
http://hdl.handle.net/1854/LU-01J73Q3F0X36FE71EVFSQ5Q591
http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-115207

Amyloid-ß can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease

Authors: Fang, Kevin Pishva, Ehsan Piers, Thomas et al.

Source: Fang, K, Pishva, E, Piers, T & Scholpp, S 2025, 'Amyloid-ß can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease', Journal of cell science, vol. 138, no. 3, jcs263526. https://doi.org/10.1242/jcs.263526

Subject Terms: Alzheimer's disease, JNK signalling, KOLF2.1J, Presenilin1, Synaptogenesis, Wnt/PCP, Alzheimer Disease/metabolism pathology genetics, Receptor Tyrosine Kinase-like Orphan Receptors/metabolism genetics, Amyloid beta-Peptides/metabolism, Wnt-5a Protein/metabolism genetics, Synapses/metabolism pathology, Humans, MAP Kinase Signaling System, Animals, Neurons/metabolism, Wnt Signaling Pathway, Induced Pluripotent Stem Cells/metabolism, Mice, Peptide Fragments/metabolism, Intercellular Signaling Peptides and Proteins/metabolism genetics

Relation: info:eu-repo/semantics/altIdentifier/eissn/1477-9137

Availability: https://cris.maastrichtuniversity.nl/en/publications/c4c070b6-4a8a-4e43-bf10-a69f06fc73c2
https://doi.org/10.1242/jcs.263526
https://www.scopus.com/pages/publications/85217987359

Functional dynamic network connectivity differentiates biological patterns in the Alzheimer's disease continuum.

Authors: Pini, L. Brusini, L. Griffa, A. et al.

Contributors: Pini, L. Brusini, L. Griffa, A. et al.

Source: Neurobiology of disease, vol. 208, pp. 106866

Subject Terms: Humans, Alzheimer Disease/physiopathology, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/pathology, Alzheimer Disease/metabolism, Male, Female, Magnetic Resonance Imaging, Aged, Nerve Net/physiopathology, Nerve Net/diagnostic imaging, Brain/physiopathology, Brain/diagnostic imaging, Brain/pathology, Middle Aged, Neural Pathways/physiopathology, Neural Pathways/diagnostic imaging, 80 and over, tau Proteins/metabolism, Brain networks, Dynamic connectivity, Molecular pathology

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Relation: info:eu-repo/semantics/altIdentifier/pmid/40081429; info:eu-repo/semantics/altIdentifier/eissn/1095-953X; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_461CA0B5B3DC6; https://serval.unil.ch/notice/serval:BIB_461CA0B5B3DC; https://serval.unil.ch/resource/serval:BIB_461CA0B5B3DC.P001/REF.pdf

Availability: https://serval.unil.ch/notice/serval:BIB_461CA0B5B3DC
https://doi.org/10.1016/j.nbd.2025.106866
https://serval.unil.ch/resource/serval:BIB_461CA0B5B3DC.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_461CA0B5B3DC6

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus.

Authors: Matera, A. Compagnion, A.C. Pedicone, C. et al.

Source: Immunity, vol. 58, no. 1, pp. 197-217.e13

Subject Terms: Animals, Microglia/metabolism, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/metabolism, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/genetics, Mice, Hippocampus/metabolism, Neuronal Plasticity, Synapses/metabolism, Synapses/physiology, Knockout, Complement System Proteins/metabolism, Complement System Proteins/immunology, Induced Pluripotent Stem Cells/metabolism, Alzheimer Disease/metabolism, Inbred C57BL, AD risk genes, Alzheimer’s disease, INPP5D, SHIP1, cognitive dysfunction, complement, microglia, synaptic pruning

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Relation: info:eu-repo/semantics/altIdentifier/pmid/39657671; info:eu-repo/semantics/altIdentifier/eissn/1097-4180; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_A27446CC92870; https://serval.unil.ch/notice/serval:BIB_A27446CC9287; https://serval.unil.ch/resource/serval:BIB_A27446CC9287.P001/REF.pdf

Availability: https://serval.unil.ch/notice/serval:BIB_A27446CC9287
https://doi.org/10.1016/j.immuni.2024.11.003
https://serval.unil.ch/resource/serval:BIB_A27446CC9287.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A27446CC92870

Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena

Authors: Mansour A. Alsaleem Hayder M. Al-kuraishy Ali I. Al-Gareeb et al.

Source: Cell Mol Neurobiol

Subject Terms: Quercetin, Antioxidants/pharmacology [MeSH], Humans [MeSH], Alzheimer Disease/drug therapy [MeSH], Antioxidants/therapeutic use [MeSH], Neurodegenerative diseases, Quercetin/therapeutic use [MeSH], Animals [MeSH], Molecular mechanism, Neuroprotective effect, Review Paper, Alzheimer's disease, Oxidative stress, Neuroprotective Agents/therapeutic use [MeSH], Quercetin/pharmacology [MeSH], Neuroprotective Agents/pharmacology [MeSH], Oxidative Stress/drug effects [MeSH], Signal Transduction/drug effects [MeSH], Alzheimer Disease/metabolism [MeSH], 0301 basic medicine, Oxidative Stress, 0303 health sciences, 03 medical and health sciences, Neuroprotective Agents, Alzheimer Disease, Humans, Animals, Antioxidants, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/39719518
https://repository.publisso.de/resource/frl:6517595