Výsledky vyhledávání - "Aging: metabolism"

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging

Autoři: Seyed Soheil Saeedi Saravi Benoit Pugin Florentin Constancias a další

Zdroj: Nat Aging
Nature aging, vol. 5, no. 6, pp. 1025-1045
Saeedi Saravi, S S, Pugin, B, Constancias, F, Shabanian, K, Spalinger, M, Thomas, A, Le Gludic, S, Shabanian, T, Karsai, G, Colucci, M, Menni, C, Attaye, I, Zhang, X, Allemann, M S, Lee, P, Visconti, A, Falchi, M, Alimonti, A, Ruschitzka, F, Paneni, F & Beer, J H 2025, ' Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging ', Nature Aging, vol. 5, no. 6, pp. 1025-1045 . https://doi.org/10.1038/s43587-025-00864-8
Nature Aging, 5 (6)

Témata: Male, Gastrointestinal Microbiome/physiology, Animals, Phenylacetates/metabolism, Phenylacetates/blood, Cellular Senescence/physiology, Cellular Senescence/drug effects, Aging/metabolism, Humans, Mice, Endothelial Cells/metabolism, Clostridium/metabolism, Mice, Inbred C57BL, Hydrogen Peroxide/metabolism, Female, Glutamine/analogs & derivatives, Glutamine/metabolism, Feces/microbiology, Feces/chemistry, Aged, Mitochondria/metabolism, Sirtuin 1/metabolism, Article

Popis souboru: application/pdf; application/application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40355758
https://serval.unil.ch/notice/serval:BIB_BF2F3CCC4022
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_BF2F3CCC40228
https://serval.unil.ch/resource/serval:BIB_BF2F3CCC4022.P001/REF.pdf
https://kclpure.kcl.ac.uk/ws/files/340199243/s43587-025-00864-8.pdf
http://hdl.handle.net/20.500.11850/736072

Multimodal neuroimaging insights into the neurobiology of healthy aging across the lifespan

Autoři: Laust Vind Knudsen Tanja Maria Michel Ziba Ahangarani Farahani a další

Zdroj: Eur J Nucl Med Mol Imaging

Témata: Male, Adult, Aging, Glucose metabolism, Middle Aged, Brain/diagnostic imaging, Multimodal Imaging, Magnetic Resonance Imaging, Functional connectivity, Young Adult, PET, Positron-Emission Tomography, Humans, Glucose/metabolism, Neuroimaging/methods, Female, Original Article, Amyloid-beta, Amyloid beta-Peptides/metabolism, Healthy Aging/metabolism, MRI, Aged

Přístupová URL adresa: https://portal.findresearcher.sdu.dk/da/publications/7ec05968-d1f4-45e5-9da8-ce02b9568865
https://doi.org/10.1007/s00259-025-07100-w

How somatic mutations cause aging without causing aging

Autoři: Wolf, Alexander Martin

Témata: Aging/metabolism, Aging, Tumor Suppressor Proteins, Stem Cells, Genes, Tumor Suppressor, Senescence-Associated Secretory Phenotype, Biological Evolution, Cellular Senescence

Aging and diet alter the protein ubiquitylation landscape in the mouse brain

Autoři: Antonio Marino Domenico Di Fraia Diana Panfilova a další

Zdroj: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-17 (2025)
Nature communications, vol. 16, no. 1, pp. 5266

Témata: Science, Animals, Ubiquitination, Brain/metabolism, Aging/metabolism, Mice, Protein Processing, Post-Translational, Mice, Inbred C57BL, Proteasome Endopeptidase Complex/metabolism, Male, Neurons/metabolism, Acetylation, Caloric Restriction, Diet, Phosphorylation, Article

Popis souboru: application/pdf

Přístupová URL adresa: https://doaj.org/article/775f740ce2e44910a97b0986b5b45dfd
https://serval.unil.ch/resource/serval:BIB_D4F4A54D562C.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_D4F4A54D562C
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D4F4A54D562C7

Loss of temporal coherence in the circadian metabolome across multiple tissues during ageing in mice

Autoři: Buijink, M.R. Weeghel, M. van Harms, A.C. a další

Zdroj: European Journal of Neuroscience. 60:3843-3857

Témata: Liver/metabolism, Male, 0301 basic medicine, Aging, Paraventricular Hypothalamic Nucleus/metabolism, Inbred C57BL, liver, Suprachiasmatic Nucleus/metabolism, Mice, 03 medical and health sciences, amine metabolism, Circadian Clocks, Animals, hypothalamus, Amines, plasma, 0303 health sciences, metabolomics, Circadian Rhythm, Aging/metabolism, Circadian Clocks/physiology, Mice, Inbred C57BL, Liver, ageing, circadian rhythms, Amines/metabolism, Metabolome, Circadian Rhythm/physiology, Suprachiasmatic Nucleus, chronobiology, Paraventricular Hypothalamic Nucleus

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38802069
https://hdl.handle.net/1887/4195877
https://pure.amsterdamumc.nl/en/publications/2c3c5c1a-64dd-48f7-a971-3b20a256231e
https://doi.org/10.1111/ejn.16428
https://hdl.handle.net/1887/4198584

Breakdown and repair of metabolism in the aging brain

Autoři: Polina Shichkova Jay S. Coggan Lida Kanari a další

Zdroj: Frontiers in Science, Vol 3 (2025)

Témata: Science, metabolism model, brain energy metabolism, brain aging, aging metabolism, neurometabolic coupling, neuro-glia-vascular system

Přístupová URL adresa: https://doaj.org/article/8431d701b1f84918a74e07beb9e22788

Cellular reprogramming by Acly inhibition using SB-204990 modulates molecular mechanisms with aging

Autoři: Sola-García, Alejandro Cáliz-Molina, María Ángeles Villanueva, Isabel Espadas a další

Témata: Aging, metabolism, 3. Good health

Editorial: Molecular mechanisms underlying exercise-alleviated sarcopenic obesity

Autoři: Estébanez González, Brisamar Huang, Chun-Jung Cuevas González, María José a další

Přispěvatelé: Estébanez González, Brisamar Huang, Chun-Jung Cuevas González, María José a další

Zdroj: Front Endocrinol (Lausanne)
BULERIA. Repositorio Institucional de la Universidad de León
Universidad de León
Frontiers in Endocrinology, Vol 15 (2024)

Témata: Resistance training (strength), Physical activity, 3109.09 Fisiología, physical activity, Body mass index - BMI, body mass index - BMI, RC648-665, Fisiología, Diseases of the endocrine glands. Clinical endocrinology, Muscle mass and function, Endocrinology, resistance training (strength), Aging metabolism, aging metabolism, muscle mass and function

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39469579
https://hdl.handle.net/10612/24130
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1498615/full
https://doaj.org/article/b8a1a8fbb2b44232bd8edee08913f03e
https://hdl.handle.net/10612/24130

Effects of age and diet consistency on the expression of myosin heavy‐chain isoforms on jaw‐closing and jaw‐opening muscles in a rat model

Autoři: Schaub, Leandra Lagou, Aikaterini Djeraba Ait-Lounis, Aouatef a další

Zdroj: Schaub, Leandra; Lagou, Aikaterini; Ait-Lounis, Aouatef; Kiliaridis, Stavros; Antonarakis, Gregory S (2024). Effects of age and diet consistency on the expression of myosin heavy-chain isoforms on jaw-closing and jaw-opening muscles in a rat model. Journal of oral rehabilitation, 51(6), pp. 1016-1024. Wiley 10.1111/joor.13676 <http://dx.doi.org/10.1111/joor.13676>

Témata: Male, Aging, Soft diet, Aging / physiology, 617.6, RNA, Messenger / metabolism, 610 Medicine & health, Masticatory Muscles / physiology, Real-Time Polymerase Chain Reaction, Jaw muscles, Animals, Protein Isoforms, Aging / metabolism, RNA, Messenger, Rats, Wistar, Masseter Muscle / physiology, 2. Zero hunger, Myosin Heavy Chains, Masseter Muscle / metabolism, Myosin Heavy Chains / metabolism, Masseter Muscle, Messenger RNA, Masticatory Muscles / metabolism, Protein Isoforms / metabolism, Age Factors, Rats, Diet, 3. Good health, Myosin heavy chains, Masticatory Muscles

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38475932
https://boris.unibe.ch/194215/

Presentation 1_Breakdown and repair of metabolism in the aging brain.zip

Autoři: Polina Shichkova Jay S. Coggan Lida Kanari a další

Témata: Uncategorized, brain aging, aging metabolism, brain energy metabolism, neurometabolic coupling, neuro-glia-vascular system, metabolism model, aging brain model, differential equations model

Relation: https://figshare.com/articles/presentation/Presentation_1_Breakdown_and_repair_of_metabolism_in_the_aging_brain_zip/28659026

Dostupnost: https://doi.org/10.3389/fsci.2025.1441297.s001
https://figshare.com/articles/presentation/Presentation_1_Breakdown_and_repair_of_metabolism_in_the_aging_brain_zip/28659026

Beyond classical collagen:basement membrane collagen IV in age-associated lung diseases

Autoři: El-Merhie, Natalia Staab-Weijnitz, Claudia A Burgess, Janette K a další

Zdroj: El-Merhie, N, Staab-Weijnitz, C A, Burgess, J K & Kwapiszewska, G 2025, 'Beyond classical collagen : basement membrane collagen IV in age-associated lung diseases', European Respiratory Review, vol. 34, no. 177, 240192. https://doi.org/10.1183/16000617.0192-2024

Témata: Humans, Basement Membrane/metabolism, Collagen Type IV/metabolism, Animals, Lung/metabolism, Lung Diseases/metabolism, Aging/metabolism, Age Factors, Airway Remodeling, Biomarkers/metabolism, Prognosis

Popis souboru: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/40701642; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/9e33e0cb-5b72-48bb-9f53-641902fcfcd6; info:eu-repo/semantics/altIdentifier/pissn/0905-9180; info:eu-repo/semantics/altIdentifier/eissn/1600-0617

Dostupnost: https://hdl.handle.net/11370/9e33e0cb-5b72-48bb-9f53-641902fcfcd6
https://research.rug.nl/en/publications/9e33e0cb-5b72-48bb-9f53-641902fcfcd6
https://doi.org/10.1183/16000617.0192-2024
https://pure.rug.nl/ws/files/1386777204/Eur_Respir_Rev-2025-El-Merhie-240192.pdf

Impact of dementia and mild cognitive impairment on bone health in older people.

Autoři: Curtis, Elizabeth M Miguel, Mario McEvoy, Claire a další

Zdroj: Aging Clinical and Experimental Research, 37 (1), 5 (2025)

Témata: Bone mineral density, Cognitive impairment, Dementia, Epidemiology, Fracture, Osteoporosis, Aged, Humans, Aging/metabolism, Bone and Bones/metabolism, Bone Density, Risk Factors, Cognitive Dysfunction/epidemiology, Cognitive Dysfunction/metabolism, Dementia/epidemiology, Dementia/metabolism, Osteoporosis/epidemiology, Osteoporosis/metabolism, Aging, Bone and Bones, Cognitive Dysfunction, Geriatrics and Gerontology, Human health sciences, Public health, health care sciences & services, Sciences de la santé humaine, Santé publique, services médicaux & soins de santé

Relation: https://link.springer.com/content/pdf/10.1007/s40520-024-02871-y.pdf; urn:issn:1594-0667; urn:issn:1720-8319; https://orbi.uliege.be/handle/2268/334683; info:hdl:2268/334683; https://orbi.uliege.be/bitstream/2268/334683/1/Impact%20of%20dementia%20and%20mild%20cognitive%20impairment%20on%20bone%20health%20in%20older%20people%20%282%29.pdf; info:pmid:39725855

Dostupnost: https://orbi.uliege.be/handle/2268/334683
https://orbi.uliege.be/bitstream/2268/334683/1/Impact%20of%20dementia%20and%20mild%20cognitive%20impairment%20on%20bone%20health%20in%20older%20people%20%282%29.pdf
https://doi.org/10.1007/s40520-024-02871-y

Julia notebook for breakdown and repair of metabolism in the aging brain

Autoři: Polina Shichkova

Témata: Computational Biology, Metabolic Medicine, Cell Physiology, Cell Metabolism, aging brain model, aging metabolism, brain aging, brain energy metabolism, differential equations model, metabolism model, neuro-glia-vascular system, neurometabolic coupling

Relation: https://figshare.com/articles/online_resource/Julia_notebook_for_breakdown_and_repair_of_metabolism_in_the_aging_brain/28653347

Dostupnost: https://doi.org/10.25453/fsci.28653347.v1
https://figshare.com/articles/online_resource/Julia_notebook_for_breakdown_and_repair_of_metabolism_in_the_aging_brain/28653347

Peripheral myelin: From development to maintenance

Autoři: Schumacher, Nathalie Vandenbosch, Renaud Franzen, Rachelle a další

Přispěvatelé: Schumacher, Nathalie Vandenbosch, Renaud Franzen, Rachelle a další

Zdroj: Journal of Neurochemistry. 169

Témata: Myelin Sheath/metabolism, 0301 basic medicine, Aging, 0303 health sciences, Schwann Cells/metabolism, myelination, Cell Differentiation, differentiation, Biochimie, biophysique & biologie moléculaire, Biochemistry, Life sciences, Aging/physiology, Aging/metabolism, Cellular and Molecular Neuroscience, 03 medical and health sciences, myelin maintenance, Sciences du vivant, Cell Differentiation/physiology, Animals, Humans, Schwann cells, Schwann Cells, Myelin Sheath/physiology, Myelin Sheath, Biochemistry, biophysics & molecular biology

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39655795

Rasopathy-Associated Mutation Ptpn11D61Y has Age-Dependent Effect on Synaptic Vesicle Recycling

Autoři: Guhathakurta, Debarpan Selzam, Franziska Petrušková, Aneta a další

Zdroj: Cell Mol Neurobiol
Cellular and Molecular Neurobiology

Témata: Neurons, 0301 basic medicine, Mice, Aging, 0303 health sciences, 03 medical and health sciences, Mutation, Animals, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Synaptic Vesicles, Mutation/genetics [MeSH], Synaptic Vesicles/metabolism [MeSH], Mice [MeSH], Aging/genetics [MeSH], Neurons/metabolism [MeSH], Aging/metabolism [MeSH], Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism [MeSH], Cells, Cultured [MeSH], Original Research, Protein Tyrosine Phosphatase, Non-Receptor Type 11/genetics [MeSH], Animals [MeSH], Cells, Cultured

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39570442
https://repository.publisso.de/resource/frl:6489145

Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans

Autoři: Kraler, Simon Balbi, Carolina Vdovenko, Daria a další

Přispěvatelé: Kraler, Simon Balbi, Carolina Vdovenko, Daria a další

Zdroj: Cardiovasc Res
Cardiovascular research, vol. 119, no. 17, pp. 2729-2742
Kraler, Simon; Balbi, Carolina; Vdovenko, Daria; Lapikova-Bryhinska, Tetiana; Camici, Giovanni G; Liberale, Luca; Bonetti, Nicole; Canestro, Candela Diaz; Burger, Fabienne; Roth, Aline; Carbone, Federico; Vassalli, Giuseppe; Mach, François; Bhasin, Shalender; Wenzl, Florian A; Muller, Olivier; Räber, Lorenz; Matter, Christian M; Montecucco, Fabrizio; Lüscher, Thomas F; ... (2023). Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans. Cardiovascular research, 119(17), pp. 2729-2742. Oxford University Press 10.1093/cvr/cvad153 <http://dx.doi.org/10.1093/cvr/cvad153>

Témata: Proteomics, Aging, Myocardial Infarction, 610 Medicine & health, Heart, 2700 General Medicine, Acute myocardial infarction, Risk prediction, 3. Good health, Aged, Animals, Humans, Mice, Aging/metabolism, Bone Morphogenetic Proteins, Growth Differentiation Factors/genetics, Growth Differentiation Factors/metabolism, Heart Injuries/complications, Heart Injuries/metabolism, Mice, Inbred C57BL, Myocardial Infarction/complications, Myocardial Infarction/metabolism, Ageing, Biomarker discovery, GDF11, Growth Differentiation Factors, Heart Injuries, 10209 Clinic for Cardiology, Original Article

Popis souboru: application/pdf; ZORA257560.pdf - application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37742057
https://archive-ouverte.unige.ch/unige:178942
https://doi.org/10.1093/cvr/cvad153
https://serval.unil.ch/notice/serval:BIB_61F93877E926
https://serval.unil.ch/resource/serval:BIB_61F93877E926.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_61F93877E9261
https://boris.unibe.ch/186551/
https://hdl.handle.net/11567/1146155
https://doi.org/10.1093/cvr/cvad153
https://www.zora.uzh.ch/id/eprint/257560/
https://doi.org/10.5167/uzh-257560

Distinctive protein expression in elderly livers in a Sprague–Dawley rat model of normothermic ex vivo liver machine perfusion

Autoři: Zimmer, Maximilian Hillebrandt, Karl Herbert Roschke, Nathalie Nora a další

Zdroj: Eur J Med Res
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-14 (2024)

Témata: Proteomics, Male, 0301 basic medicine, Aging, 0303 health sciences, Liver transplantation, Normothermic machine perfusion, Research, Organ Preservation, Proteomics/methods [MeSH], Organ Preservation/methods [MeSH], Humans [MeSH], Liver/metabolism [MeSH], Aging/metabolism [MeSH], Rats [MeSH], Rats, Sprague-Dawley [MeSH], Oxidative Stress [MeSH], Animals [MeSH], Oxidative stress, Male [MeSH], Perfusion/methods [MeSH], Liver Transplantation/methods [MeSH], Rats, Liver Transplantation, Rats, Sprague-Dawley, Perfusion, Oxidative Stress, 03 medical and health sciences, Liver, Medicine, Animals, Humans

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38992689
https://doaj.org/article/97915733214b4c90b2a9ed1e285a1b80
https://repository.publisso.de/resource/frl:6490183

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging

Autoři: Santinha, Deolinda Vilaça, Andreia Estronca, Luís a další

Zdroj: http://lobid.org/resources/99370695145206441#!, 23(1):100706.

Témata: Heart [MeSH], Endothelial Cells/metabolism [MeSH], Humans, Humans [MeSH], Proteome/metabolism, Aging/metabolism [MeSH], Extracellular Matrix/metabolism [MeSH], Heart, Aging/metabolism, Extracellular Matrix/metabolism, Extracellular Matrix Proteins/metabolism, Proteome/metabolism [MeSH], Extracellular Matrix Proteins/metabolism [MeSH], Endothelial Cells/metabolism

Relation: https://repository.publisso.de/resource/frl:6475532; https://doi.org/10.1016/j.mcpro.2023.100706; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828820/

Dostupnost: https://repository.publisso.de/resource/frl:6475532
https://doi.org/10.1016/j.mcpro.2023.100706
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828820/

Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats

Autoři: Marie-Sophie Narzt Christopher Kremslehner Bahar Golabi a další

Zdroj: Amino Acids

Témata: 0301 basic medicine, Aging, Memory Disorders, 0303 health sciences, Memory Disorders/metabolism, Phosphorylcholine, Hippocampus/metabolism, Brain, 106025 Neurobiology, Prefrontal cortex, Hippocampus, Rats, Aging/metabolism, 03 medical and health sciences, Memory, Brain/metabolism, Learning, Animals, Humans, Original Article, 106025 Neurobiologie, Phospholipids/metabolism, Phospholipids, Phosphorylcholine/metabolism, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/35817992

Abnormal Regulation of Mitochondrial Sphingolipids during Aging and Alzheimer’s Disease

Autoři: Simone M. Crivelli Zainuddin Quadri Ahmed Elsherbini a další

Zdroj: ASN Neuro

Témata: Male, Sphingolipids, Aging, sphingosine, Sphingolipids/metabolism, Mice, Transgenic, 5xFAD, Transgenic, Mitochondria, mitochondria, Aging/metabolism, Mice, Alzheimer Disease, Mitochondria/metabolism, Animals, Humans, Female, ceramide, Alzheimer's disease, Alzheimer Disease/metabolism pathology, Research Article, Aged

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39499163
https://cris.maastrichtuniversity.nl/en/publications/275870ad-aeed-40bb-ac0d-6284a1ebbc72
https://doi.org/10.1080/17590914.2024.2404367