Suchergebnisse - "Adverse outcome pathways"

Refining the AOP for retinoid-induced teratogenicity: Insights into RAR/RXR overactivation and RXR cross-talk with retinoic acid and thyroid hormone signaling.

Autoren: Phan A Pesce E Baumann L et al.

Quelle: Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2025 Dec; Vol. 289, pp. 107608. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8500246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1514 (Electronic) Linking ISSN: 0166445X NLM ISO Abbreviation: Aquat Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Zebrafish*/embryology , Tretinoin*/toxicity , Retinoid X Receptors*/metabolism , Receptors, Retinoic Acid*/metabolism , Thyroid Hormones*/metabolism , Adverse Outcome Pathways* , Teratogens*/toxicity , Retinoids*/toxicity, Animals ; Signal Transduction/drug effects ; Embryo, Nonmammalian/drug effects

Exploration of oxidative stress-mediated genetic toxicology modes of action using a pathway analysis, Connectivity Mapping, and transcriptional benchmark dosing-based framework.

Autoren: De Abrew KN Selman BG Shobair M et al.

Quelle: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 Dec 01; Vol. 208 (2), pp. 401-417.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

MeSH-Schlagworte: Oxidative Stress*/drug effects , Oxidative Stress*/genetics , Mutagens*/toxicity , Adverse Outcome Pathways* , Transcription, Genetic*/drug effects, Humans ; Dose-Response Relationship, Drug ; Reactive Oxygen Species/metabolism ; Mutagenicity Tests ; DNA Damage ; Benchmarking ; Animals

Bridging planarian bioassays and AOP-based environmental assessment: Toward mechanistic insights into pollutant-induced disruptions.

Autoren: Xie C Li X Wu X et al.

Quelle: Environmental research [Environ Res] 2025 Dec 01; Vol. 286 (Pt 1), pp. 122787. Date of Electronic Publication: 2025 Sep 06.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE

MeSH-Schlagworte: Planarians*/drug effects , Ecotoxicology*/methods , Biological Assay*/methods , Environmental Monitoring*/methods , Adverse Outcome Pathways* , Water Pollutants, Chemical*/toxicity , Environmental Pollutants*/toxicity, Animals

AOP report: adverse outcome pathway network for developmental androgen signaling inhibition leading to short anogenital distance in male offspring.

Autoren: Svingen T Elmelund E Holmer ML et al.

Quelle: Environmental toxicology and chemistry [Environ Toxicol Chem] 2025 Dec 01; Vol. 44 (12), pp. 3431-3441.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8308958 Publication Model: Print Cited Medium: Internet ISSN: 1552-8618 (Electronic) Linking ISSN: 07307268 NLM ISO Abbreviation: Environ Toxicol Chem Subsets: MEDLINE

MeSH-Schlagworte: Androgens*/metabolism , Adverse Outcome Pathways* , Signal Transduction*/drug effects , Anal Canal*/anatomy & histology , Genitalia, Male*/drug effects, Animals ; Male ; Female ; Humans ; Rats ; Mice

Developmental toxicity of microplastics in human stem cells using adverse outcome pathway based integrated approaches to testing and assessment approach.

Autoren: Jeong J Kang K Kim H et al.

Quelle: Toxicology [Toxicology] 2025 Dec; Vol. 518, pp. 154268. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE

MeSH-Schlagworte: Microplastics*/toxicity , Adverse Outcome Pathways* , Human Embryonic Stem Cells*/drug effects , Human Embryonic Stem Cells*/pathology , Toxicity Tests*/methods , Polystyrenes*/toxicity, Humans ; Cell Differentiation/drug effects ; Risk Assessment ; Cell Survival/drug effects

Adverse outcome pathway networks of microplastic ecotoxicity to aquatic organisms: A critical review.

Autoren: Mut NNN Cao Z Na J et al.

Quelle: Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2025 Dec; Vol. 289, pp. 107594. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier/North Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8500246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1514 (Electronic) Linking ISSN: 0166445X NLM ISO Abbreviation: Aquat Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Microplastics*/toxicity , Water Pollutants, Chemical*/toxicity , Aquatic Organisms*/drug effects , Adverse Outcome Pathways*, Animals ; Ecotoxicology

Adverse Outcome Pathways Applied to Space Radiation Research.

Autoren: Chauhan V Grybas VS Hoopfer D et al.

Quelle: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2025 Oct; Vol. 66 (8), pp. 442-462. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2280 (Electronic) Linking ISSN: 08936692 NLM ISO Abbreviation: Environ Mol Mutagen Subsets: MEDLINE

MeSH-Schlagworte: Space Flight* , Adverse Outcome Pathways* , Cosmic Radiation*/adverse effects , Radiation Exposure*/adverse effects, Humans ; DNA Damage/radiation effects ; Astronauts ; Oxidative Stress/radiation effects

A multi-tiered workflow for constructing a quantitative adverse outcome pathway network for gamma radiation-induced reproductive inhibition in Lemna minor.

Autoren: Xie L Tollefsen KE

Quelle: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Oct 01; Vol. 304, pp. 119129. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH-Schlagworte: Gamma Rays*/adverse effects , Araceae*/radiation effects , Araceae*/physiology , Adverse Outcome Pathways*, Reproduction/radiation effects ; Workflow ; Cobalt Radioisotopes/toxicity ; Dose-Response Relationship, Radiation

SCR Organism: Lemna minor

Targeted RNA-sequencing of testes from fetal rats exposed to dicyclohexyl phthalate informs potency and adverse outcome pathway development.

Autoren: Waterbury CR Crockett MN Conley JM et al.

Quelle: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 Oct 01; Vol. 207 (2), pp. 372-382.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

MeSH-Schlagworte: Phthalic Acids*/toxicity , Testis*/drug effects , Testis*/metabolism , Testis*/embryology , Adverse Outcome Pathways*, Animals ; Male ; Female ; Pregnancy ; Sequence Analysis, RNA ; Rats ; Dose-Response Relationship, Drug ; Rats, Sprague-Dawley

Adverse Outcome Pathway (AOP) Coaching Program-how it functions and contributes to a more harmonized approach to AOP development and construction of AOP networks with regulatory utility.

Autoren: Tanabe S Burgdorf T Choi J et al.

Quelle: Environmental toxicology and chemistry [Environ Toxicol Chem] 2025 Oct 01; Vol. 44 (10), pp. 2725-2732.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8308958 Publication Model: Print Cited Medium: Internet ISSN: 1552-8618 (Electronic) Linking ISSN: 07307268 NLM ISO Abbreviation: Environ Toxicol Chem Subsets: MEDLINE

MeSH-Schlagworte: Adverse Outcome Pathways*, Humans ; Organisation for Economic Co-Operation and Development ; Mentoring

De-risking seizure liability: integrating adverse outcome pathways (AOPs), new approach methodologies (NAMs), and in silico approaches while highlighting knowledge gaps.

Autoren: Behl M Karmaus A Rao M et al.

Quelle: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 Oct 01; Vol. 207 (2), pp. 306-319.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

MeSH-Schlagworte: Seizures*/chemically induced , Adverse Outcome Pathways* , Computer Simulation*, Humans ; Animals ; Risk Assessment

Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer.

Autoren: Jaylet T Chauhan V Mezquita L et al.

Quelle: Frontiers in public health [Front Public Health] 2025 Jul 31; Vol. 13, pp. 1571290. Date of Electronic Publication: 2025 Jul 31 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE

MeSH-Schlagworte: Radon*/adverse effects , Lung Neoplasms*/etiology , Lung Neoplasms*/epidemiology , Tobacco Smoke Pollution*/adverse effects , Adverse Outcome Pathways* , Environmental Exposure*/adverse effects, Humans ; Risk Factors

Carcinogenic risks of aromatic amines and their radical oxidation products: Construction of adverse outcome pathways, development of priority control lists, and mechanistic analysis of carcinogenesis.

Autoren: Liu Y Cui Y Xu Y et al.

Quelle: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Sep 15; Vol. 303, pp. 119037. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH-Schlagworte: Carcinogens*/toxicity , Carcinogens*/chemistry , Amines*/toxicity , Amines*/chemistry , Adverse Outcome Pathways*, Humans ; Oxidation-Reduction ; Molecular Docking Simulation ; Risk Assessment ; Carcinogenesis ; Cytochrome P-450 Enzyme System/metabolism

Connecting volatile organic compounds exposure to osteoporosis risk via oxidative stress based on adverse outcome pathway methodology.

Autoren: Zhou H Cui Z Di D et al.

Quelle: Journal of environmental sciences (China) [J Environ Sci (China)] 2025 Sep; Vol. 155, pp. 806-817. Date of Electronic Publication: 2024 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE

MeSH-Schlagworte: Volatile Organic Compounds*/toxicity , Osteoporosis*/epidemiology , Osteoporosis*/chemically induced , Oxidative Stress* , Adverse Outcome Pathways* , Environmental Exposure*/statistics & numerical data , Air Pollutants*, Humans ; Middle Aged ; Female ; Male ; Adult ; Nutrition Surveys ; Aged

Developing adverse outcome pathways to support radioecological risk assessment: challenges and insights.

Autoren: Dufourcq Sekatcheff E Quevarec L Delignette-Muller ML et al.

Quelle: Environmental toxicology and chemistry [Environ Toxicol Chem] 2025 Sep 01; Vol. 44 (9), pp. 2414-2437.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8308958 Publication Model: Print Cited Medium: Internet ISSN: 1552-8618 (Electronic) Linking ISSN: 07307268 NLM ISO Abbreviation: Environ Toxicol Chem Subsets: MEDLINE

MeSH-Schlagworte: Adverse Outcome Pathways*, Risk Assessment/methods ; Animals ; Humans ; Ecology

Bridging the gap between human toxicology and ecotoxicology under one health perspective by a cross-species adverse outcome pathway network for reproductive toxicity.

Autoren: Dufourcq Sekatcheff E Jeong J Choi J

Quelle: Environmental toxicology and chemistry [Environ Toxicol Chem] 2025 Sep 01; Vol. 44 (9), pp. 2511-2523.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8308958 Publication Model: Print Cited Medium: Internet ISSN: 1552-8618 (Electronic) Linking ISSN: 07307268 NLM ISO Abbreviation: Environ Toxicol Chem Subsets: MEDLINE

MeSH-Schlagworte: Ecotoxicology* , Adverse Outcome Pathways* , Reproduction*/drug effects , Environmental Pollutants*/toxicity, Humans ; Animals ; Risk Assessment ; Caenorhabditis elegans/drug effects

Adverse outcome pathway (AOP) framework for predicting toxic mechanisms in E-cigarette-induced lung injury.

Autoren: Chen Y Jiang H Liu W et al.

Quelle: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Sep 01; Vol. 302, pp. 118703. Date of Electronic Publication: 2025 Jul 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

MeSH-Schlagworte: Electronic Nicotine Delivery Systems* , Lung Injury*/chemically induced , Adverse Outcome Pathways*, Animals ; Humans ; Mice ; Nicotine/toxicity ; Glycerol/toxicity ; Propylene Glycol/toxicity ; Toxicogenetics

An adverse outcome pathway for DNA adduct formation leading to kidney failure.

Autoren: Barnes DA Janssen MJ Yang H et al.

Quelle: Toxicology [Toxicology] 2025 Aug; Vol. 515, pp. 154162. Date of Electronic Publication: 2025 Apr 22.

Publikationsart: Journal Article; Review; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE

MeSH-Schlagworte: DNA Adducts*/metabolism , Antineoplastic Agents*/toxicity , Antineoplastic Agents*/adverse effects , Adverse Outcome Pathways* , Renal Insufficiency*/chemically induced , Renal Insufficiency*/metabolism , Renal Insufficiency*/pathology, Humans ; Animals ; DNA Damage ; Reactive Oxygen Species/metabolism ; Risk Assessment ; Cisplatin/toxicity ; Oxidative Stress/drug effects

Advancing Genotoxicity Assessment by Building a Global AOP Network.

Autoren: Demuynck E Vanhaecke T Thienpont A et al.

Quelle: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2025 Aug; Vol. 66 (6-7), pp. 341-366. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2280 (Electronic) Linking ISSN: 08936692 NLM ISO Abbreviation: Environ Mol Mutagen Subsets: MEDLINE

MeSH-Schlagworte: Adverse Outcome Pathways* , Mutagens*/toxicity, Animals ; Humans ; Animal Testing Alternatives/methods ; DNA Damage/drug effects ; Mutagenicity Tests/methods ; Risk Assessment/methods

AOP-helpFinder 3.0: from text mining to network visualization of key event relationships, and knowledge integration from multiple sources.

Autoren: Jaylet T Jornod F Capdet Q et al.

Quelle: Bioinformatics (Oxford, England) [Bioinformatics] 2025 Jul 01; Vol. 41 (7).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9808944 Publication Model: Print Cited Medium: Internet ISSN: 1367-4811 (Electronic) Linking ISSN: 13674803 NLM ISO Abbreviation: Bioinformatics Subsets: MEDLINE

MeSH-Schlagworte: Data Mining*/methods , Software* , Adverse Outcome Pathways* , Computational Biology*/methods, Humans ; Natural Language Processing