Search Results - "Adenocarcinoma/genetics [MeSH]"

Colorectal adenocarcinoma with clear cell changes: immunohistological and molecular findings in three cases

Authors: Andreas Gocht Carsten Heidel Jutta Kirfel et al.

Source: Virchows Arch

Subject Terms: Male, Brief Report, Female [MeSH], Aged [MeSH], Humans [MeSH], Middle Aged [MeSH], Adenocarcinoma, Clear Cell/genetics [MeSH], Immunohistochemistry [MeSH], Adenocarcinoma, Clear Cell/pathology [MeSH], Male [MeSH], Adenocarcinoma/pathology [MeSH], Colorectal Neoplasms/pathology [MeSH], Biomarkers, Tumor/genetics [MeSH], Adenocarcinoma/genetics [MeSH], Colorectal Neoplasms/genetics [MeSH], Biomarkers, Tumor/analysis [MeSH], Adenocarcinoma, Clear Cell/metabolism [MeSH], Biomarkers, Tumor, Humans, Female, Middle Aged, Adenocarcinoma, Colorectal Neoplasms, Immunohistochemistry, Aged, Adenocarcinoma, Clear Cell

Access URL: https://pubmed.ncbi.nlm.nih.gov/39039246
https://repository.publisso.de/resource/frl:6490149

Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors

Authors: Marcell Baranyi Eszter Molnár Luca Hegedűs et al.

Source: Br J Cancer

Subject Terms: 0301 basic medicine, 0303 health sciences, Lung Neoplasms, Medizin, Adenocarcinoma of Lung, Adenocarcinoma, Article, 3. Good health, Adenocarcinoma of Lung [MeSH], Pancreatic Neoplasms/genetics [MeSH], Mutation [MeSH], Humans [MeSH], Lung Neoplasms/genetics [MeSH], Colorectal Neoplasms/drug therapy [MeSH], Animals [MeSH], Pancreatic Neoplasms/drug therapy [MeSH], 631/67/1612, Proto-Oncogene Proteins p21(ras)/genetics [MeSH], Enzyme Inhibitors/pharmacology [MeSH], Adenocarcinoma/drug therapy [MeSH], Adenocarcinoma/genetics [MeSH], Transferases [MeSH], 631/67/1504, Colorectal Neoplasms/genetics [MeSH], 631/67/1059, Lung Neoplasms/drug therapy [MeSH], Disease Models, Animal [MeSH], article, Pancreatic Neoplasms, Proto-Oncogene Proteins p21(ras), Disease Models, Animal, 03 medical and health sciences, Transferases, Mutation, Humans, Animals, Enzyme Inhibitors, Colorectal Neoplasms

Access URL: https://pubmed.ncbi.nlm.nih.gov/38278976
https://repository.publisso.de/resource/frl:6518913
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85183191581
https://doi.org/10.1038/s41416-024-02586-x
https://www.ncbi.nlm.nih.gov/pubmed/38278976

SMARCB1-deficient sinonasal adenocarcinoma: a rare variant of SWI/SNF-deficient malignancy often misclassified as high-grade non-intestinal-type sinonasal adenocarcinoma or myoepithelial carcinoma

Authors: Skálová, Alena Taheri, Touraj Bradová, Martina et al.

Source: Virchows Arch

Subject Terms: Male, Adult, Aged, 80 and over, Aged, 80 and over [MeSH], Neoplasm Grading [MeSH], Aged [MeSH], Rhabdoid, Transcription Factors/genetics [MeSH], DNA-Binding Proteins/deficiency [MeSH], DNA-Binding Proteins/genetics [MeSH], Diagnosis, Differential [MeSH], Yolk sac-like, Original Article, SMARCB1-deficient adenocarcinoma, SMARCB1 Protein/deficiency [MeSH], Male [MeSH], Paranasal Sinus Neoplasms/genetics [MeSH], Adenocarcinoma/pathology [MeSH], SWI/SNF complex, Next-generation sequencing, Sinonasal, Myoepithelioma/genetics [MeSH], Transcription Factors/deficiency [MeSH], Female [MeSH], Mutation [MeSH], Adult [MeSH], Head and neck, Humans [MeSH], Myoepithelioma/pathology [MeSH], Middle Aged [MeSH], Paranasal Sinus Neoplasms/pathology [MeSH], Biomarkers, Tumor/genetics [MeSH], Adenocarcinoma/genetics [MeSH], SMARCB1 Protein/genetics [MeSH], In Situ Hybridization, Fluorescence [MeSH], High-Throughput Nucleotide Sequencing [MeSH], High-Throughput Nucleotide Sequencing, SMARCB1 Protein, Middle Aged, Adenocarcinoma, Myoepithelioma, 3. Good health, DNA-Binding Proteins, Diagnosis, Differential, Mutation, Biomarkers, Tumor, Humans, Female, Neoplasm Grading, Paranasal Sinus Neoplasms, In Situ Hybridization, Fluorescence, Aged, Transcription Factors

Access URL: https://pubmed.ncbi.nlm.nih.gov/38085333
https://repository.publisso.de/resource/frl:6523009
https://hdl.handle.net/11568/1232029
https://doi.org/10.1007/s00428-023-03650-2

Elevated expression levels of the protein kinase DYRK1B induce mesenchymal features in A549 lung cancer cells

Authors: Sester, Soraya Wilms, Gerrit Ahlburg, Joana et al.

Source: BMC Cancer
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
BMC cancer 24(1), 1341 (2024). doi:10.1186/s12885-024-13057-0

Subject Terms: Lung adenocarcinoma, Epithelial-Mesenchymal Transition, Lung Neoplasms, Adenocarcinoma of Lung, Phenotypic plasticity, Protein Serine-Threonine Kinases, Adenocarcinoma, Dyrk Kinases, Protein kinase, Gene Expression Regulation, Neoplastic [MeSH], Cell Line, Tumor [MeSH], Lung Neoplasms/genetics [MeSH], Protein-Tyrosine Kinases/genetics [MeSH], Adenocarcinoma/metabolism [MeSH], Dyrk Kinases [MeSH], Adenocarcinoma/pathology [MeSH], Adenocarcinoma of Lung/genetics [MeSH], Protein-Tyrosine Kinases/metabolism [MeSH], Stress fibers, DYRK1B, Snail Family Transcription Factors/metabolism [MeSH], A549 Cells [MeSH], Cell Proliferation [MeSH], Cell Movement/genetics [MeSH], Humans [MeSH], Protein Serine-Threonine Kinases/genetics [MeSH], Cancer cell migration, A549, Adenocarcinoma of Lung/metabolism [MeSH], Epithelial-Mesenchymal Transition/genetics [MeSH], Research, Adenocarcinoma/genetics [MeSH], Lung Neoplasms/pathology [MeSH], Lung Neoplasms/metabolism [MeSH], Protein Serine-Threonine Kinases/metabolism [MeSH], Adenocarcinoma of Lung/pathology [MeSH], Snail Family Transcription Factors/genetics [MeSH], Cell Movement, Cell Line, Tumor, Humans, RC254-282, Cell Proliferation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Protein-Tyrosine Kinases, Gene Expression Regulation, Neoplastic, A549 Cells, Snail Family Transcription Factors

Access URL: https://pubmed.ncbi.nlm.nih.gov/39482615
https://doaj.org/article/ac9580bd985c4899aeda27c32269f6a5
https://repository.publisso.de/resource/frl:6508823
https://publications.rwth-aachen.de/record/996871

PARP1-targeted fluorescence molecular endoscopy as novel tool for early detection of esophageal dysplasia and adenocarcinoma

Authors: Sabrina Marcazzan Marcos J. Braz Carvalho Nghia T. Nguyen et al.

Source: J Exp Clin Cancer Res
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)

Subject Terms: Dysplasia, Esophageal Neoplasms, Poly (ADP-Ribose) Polymerase-1, Mice, Transgenic, Research, Esophageal Adenocarcinoma, PARP1, Fluorescence Molecular Endoscopy, Fluorescence Imaging, Animal Models, Adenocarcinoma, Mice, Barrett Esophagus, 03 medical and health sciences, 0302 clinical medicine, Humans, Animals, RC254-282, Early Detection of Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Endoscopy, Esophageal Neoplasms/genetics [MeSH], Humans [MeSH], Esophageal Neoplasms/diagnostic imaging [MeSH], Animals [MeSH], Endoscopy [MeSH], Barrett Esophagus/diagnosis [MeSH], Barrett Esophagus/pathology [MeSH], Mice, Transgenic [MeSH], Mice [MeSH], Early Detection of Cancer [MeSH], Barrett Esophagus/genetics [MeSH], Adenocarcinoma/genetics [MeSH], Adenocarcinoma/diagnostic imaging [MeSH], Poly (ADP-Ribose) Polymerase-1/genetics [MeSH], ddc, 3. Good health

File Description: application/pdf; pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38383387
https://doaj.org/article/ff6d310172284ca49bcfc681bab115a2
https://repository.publisso.de/resource/frl:6498255
https://mediatum.ub.tum.de/1770429

The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis

Authors: Adrian Georg Simon Su Ir Lyu Mark Laible et al.

Source: J Transl Med
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)

Subject Terms: Gastric cancer, Stomach Neoplasms/genetics [MeSH], Humans [MeSH], CLDN6, CAR T-cell therapy, Tight Junction Proteins [MeSH], Aminocaproic Acid [MeSH], Medical and Health Sciences, Adenocarcinoma, Research, Esophageal cancer, Immunotherapy, Adenocarcinoma/genetics [MeSH], Combination strategies, Claudins/genetics [MeSH], Claudin, Tight junctions, Antibodies [MeSH], Tight Junction Proteins, Esophageal Neoplasms, Antibodies, 3. Good health, Stomach Neoplasms, Aminocaproic Acid, Claudins, Medicine, Humans, ddc:610

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/37592303
https://doaj.org/article/955b99c2c4e6441e84f326d2f0b2a4bd
https://repository.publisso.de/resource/frl:6484331
http://doi.org/10.1186/s12967-023-04433-8

High NANOG expression correlates with worse patients’ survival in esophageal adenocarcinoma

Authors: Knipper, Karl Damanakis, Alexander I. Lyu, Su Ir et al.

Source: BMC Cancer
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)

Subject Terms: Esophageal Neoplasms, Research, Stem Cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Adenocarcinoma/therapy [MeSH], Esophageal Neoplasms/genetics [MeSH], Esophageal Neoplasms/therapy [MeSH], Nanog Homeobox Protein/metabolism [MeSH], Humans [MeSH], NANOG, Multimodal therapy, Stem Cells/metabolism [MeSH], Adenocarcinoma/metabolism [MeSH], Personalized medicine, Medical and Health Sciences, Prognosis [MeSH], Adenocarcinoma/genetics [MeSH], Esophageal adenocarcinoma, Nanog Homeobox Protein/genetics [MeSH], Multivariate Analysis [MeSH], Nanog Homeobox Protein, Adenocarcinoma, Prognosis, 3. Good health, Multivariate Analysis, Humans, ddc:610, RC254-282

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/37461005
https://doaj.org/article/c2888846eb4c48eb982ddd3ec82869ca
https://repository.publisso.de/resource/frl:6484357
http://doi.org/10.1186/s12885-023-11146-0

GATA binding protein 6 (GATA6) is co-amplified with PIK3CA in patients with esophageal adenocarcinoma and is linked to neoadjuvant therapy

Authors: Patrick Sven Plum Heike Löser Thomas Zander et al.

Source: J Cancer Res Clin Oncol

Subject Terms: Adult, Aged, 80 and over, Male, 0301 basic medicine, Esophageal Neoplasms, Class I Phosphatidylinositol 3-Kinases, Gene Amplification, Aged, 80 and over [MeSH], Esophageal Neoplasms/genetics [MeSH], Aged [MeSH], Neoadjuvant Therapy/mortality [MeSH], Gene Amplification [MeSH], Esophageal Neoplasms/pathology [MeSH], Treatment response, Prognosis, Esophageal Neoplasms/drug therapy [MeSH], Biomarker, EAC, Neoadjuvant treatment, Male [MeSH], Neoadjuvant therapy, Adenocarcinoma/drug therapy [MeSH], Adenocarcinoma/pathology [MeSH], Female [MeSH], Follow-Up Studies [MeSH], Original Article – Cancer Research, Adult [MeSH], Humans [MeSH], GATA6 Transcription Factor/genetics [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], PIK3CA, Survival Rate [MeSH], GATA6, Class I Phosphatidylinositol 3-Kinases/genetics [MeSH], Prognosis [MeSH], Adenocarcinoma/genetics [MeSH], Esophageal adenocarcinoma, Adenocarcinoma, Middle Aged, Neoadjuvant Therapy, 3. Good health, Survival Rate, 03 medical and health sciences, 0302 clinical medicine, GATA6 Transcription Factor, Humans, Female, Aged, Follow-Up Studies, Retrospective Studies

Access URL: https://link.springer.com/content/pdf/10.1007/s00432-020-03486-2.pdf
https://pubmed.ncbi.nlm.nih.gov/33300112
https://link.springer.com/article/10.1007/s00432-020-03486-2
https://pubmed.ncbi.nlm.nih.gov/33300112/
https://europepmc.org/article/MED/33300112
https://www.ncbi.nlm.nih.gov/pubmed/33300112
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954758
https://link.springer.com/content/pdf/10.1007/s00432-020-03486-2.pdf
https://repository.publisso.de/resource/frl:6469412

Gamma-delta T cells stimulate IL-6 production by pancreatic stellate cells in pancreatic ductal adenocarcinoma

Authors: Lena Seifert Daniela Aust Julian List et al.

Source: J Cancer Res Clin Oncol

Subject Terms: 0301 basic medicine, Carcinogenesis, Interleukin-6, Pancreatic Stellate Cells, Adenocarcinoma, Coculture Techniques, Extracellular Matrix, 3. Good health, Gene Expression Regulation, Neoplastic, 03 medical and health sciences, Gene Expression Regulation, Neoplastic [MeSH], Carcinoma, Pancreatic Ductal/immunology [MeSH], Cell Line, Tumor [MeSH], Cell Proliferation [MeSH], Original Article – Cancer Research, Humans [MeSH], Intraepithelial Lymphocytes/immunology [MeSH], Extracellular Matrix/genetics [MeSH], Pancreatic Stellate Cells/metabolism [MeSH], Pancreatic Stellate Cells/immunology [MeSH], Carcinoma, Pancreatic Ductal/genetics [MeSH], Carcinoma, Pancreatic Ductal/pathology [MeSH], Adenocarcinoma/pathology [MeSH], Adenocarcinoma/genetics [MeSH], Adenocarcinoma/immunology [MeSH], Interleukin-6/genetics [MeSH], Coculture Techniques [MeSH], Carcinogenesis/immunology [MeSH], Gamma-delta T cells, Tumor Microenvironment/genetics [MeSH], Carcinogenesis/genetics [MeSH], Pancreatic stellate cells, IL-6, Pancreatic cancer, Cell Line, Tumor, Tumor Microenvironment, Humans, Intraepithelial Lymphocytes, Carcinoma, Pancreatic Ductal, Cell Proliferation

Access URL: https://link.springer.com/content/pdf/10.1007/s00432-020-03367-8.pdf
https://pubmed.ncbi.nlm.nih.gov/32865617
https://www.ncbi.nlm.nih.gov/pubmed/32865617
https://link.springer.com/content/pdf/10.1007/s00432-020-03367-8.pdf
https://europepmc.org/articles/PMC7679341/
https://pubmed.ncbi.nlm.nih.gov/32865617/
https://link.springer.com/article/10.1007/s00432-020-03367-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679341
https://repository.publisso.de/resource/frl:6469386

Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data

Authors: Hescheler, Daniel A. Plum, Patrick S. Zander, Thomas et al.

Source: Gastric Cancer

Subject Terms: 0301 basic medicine, Genome, Human, Antineoplastic Agents, Stomach Neoplasms/genetics [MeSH], Targeted molecular therapy, Humans [MeSH], Stomach Neoplasms/pathology [MeSH], New treatment advances, Genomics/methods [MeSH], Genome, Human [MeSH], Original Article, Molecular Targeted Therapy [MeSH], Human genome project, Adenocarcinoma/drug therapy [MeSH], Adenocarcinoma/pathology [MeSH], Biomarkers, Tumor/genetics [MeSH], Drug Resistance, Neoplasm/genetics [MeSH], Prognosis [MeSH], Antineoplastic Agents/therapeutic use [MeSH], Adenocarcinoma/genetics [MeSH], Stomach Neoplasms/drug therapy [MeSH], Transcriptome [MeSH], Stomach neoplasms, Genomics, Adenocarcinoma, Prognosis, 3. Good health, 03 medical and health sciences, Drug Resistance, Neoplasm, Stomach Neoplasms, Biomarkers, Tumor, Humans, Molecular Targeted Therapy, Transcriptome

Access URL: https://link.springer.com/content/pdf/10.1007/s10120-020-01045-9.pdf
https://pubmed.ncbi.nlm.nih.gov/32107691
https://pubmed.ncbi.nlm.nih.gov/32107691/
https://link.springer.com/article/10.1007/s10120-020-01045-9
https://link.springer.com/content/pdf/10.1007/s10120-020-01045-9.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305081
https://repository.publisso.de/resource/frl:6470530

Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma

Authors: Svenja Wagener-Ryczek Max Schoemmel Max Kraemer et al.

Source: Cancer Immunol Immunother

Subject Terms: Male, 0301 basic medicine, B7 Antigens, Esophageal Neoplasms, Gene Expression Profiling, T-Lymphocytes, Chemoradiotherapy, Adenocarcinoma, Middle Aged, Neoadjuvant Therapy, 3. Good health, Esophagectomy, Gene Expression Regulation, Neoplastic, 03 medical and health sciences, 0302 clinical medicine, Gene Expression Regulation, Neoplastic [MeSH], Esophageal Neoplasms/genetics [MeSH], T-Lymphocytes/metabolism [MeSH], Immune profile, Esophageal Neoplasms/immunology [MeSH], Nanostring, Neoadjuvant Therapy [MeSH], Original Article, B7 Antigens/genetics [MeSH], Male [MeSH], Adenocarcinoma/immunology [MeSH], Monitoring, Immunologic [MeSH], CTLA-4 Antigen/immunology [MeSH], Female [MeSH], Adenocarcinoma/therapy [MeSH], Esophageal Neoplasms/therapy [MeSH], B7 Antigens/immunology [MeSH], T-Lymphocytes/immunology [MeSH], Humans [MeSH], Chemoradiotherapy/methods [MeSH], Middle Aged [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], CTLA-4 Antigen/genetics [MeSH], Esophagectomy/methods [MeSH], Adenocarcinoma/genetics [MeSH], Gene Expression Profiling/methods [MeSH], Esophageal adenocarcinoma, RNA expression, Monitoring, Immunologic, Antineoplastic Combined Chemotherapy Protocols, Humans, CTLA-4 Antigen, Female

Access URL: https://link.springer.com/content/pdf/10.1007/s00262-019-02475-w.pdf
https://pubmed.ncbi.nlm.nih.gov/31960110
https://link.springer.com/article/10.1007/s00262-019-02475-w
https://www.ncbi.nlm.nih.gov/pubmed/31960110
https://link.springer.com/content/pdf/10.1007%2Fs00262-019-02475-w.pdf
https://europepmc.org/article/PMC/PMC7113210
https://pubmed.ncbi.nlm.nih.gov/31960110/
https://repository.publisso.de/resource/frl:6470314

Analysis of Interleukin-1 Signaling Alterations of Colon Adenocarcinoma Identified Implications for Immunotherapy

Authors: Zhou, Xiaogang Liu, Yu Xiang, Jing et al.

Source: Frontiers in immunology, 12:665002

Subject Terms: Gene Expression Regulation, Neoplastic [MeSH], IL-1, Colonic Neoplasms/immunology [MeSH], Colonic Neoplasms/mortality [MeSH], prognosis, Immunotherapy [MeSH], Tumor Microenvironment/immunology [MeSH], Cohort Studies [MeSH], Adenocarcinoma/drug therapy [MeSH], Adenocarcinoma/immunology [MeSH], tumor microenvironment, Interleukin-1/genetics [MeSH], Immunology, Mutation [MeSH], Humans [MeSH], Interleukin-1/immunology [MeSH], Survival Analysis [MeSH], Colonic Neoplasms/genetics [MeSH], colon adenocarcinoma, Colonic Neoplasms/drug therapy [MeSH], Biomarkers, Tumor/genetics [MeSH], Prognosis [MeSH], Adenocarcinoma/genetics [MeSH], Tumor/immunology [MeSH], Adenocarcinoma/mortality [MeSH], Tumor Microenvironment/genetics [MeSH], immune checkpoint inhibitors

Relation: https://repository.publisso.de/resource/frl:6479656; https://doi.org/10.3389/fimmu.2021.665002; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344046/

Availability: https://repository.publisso.de/resource/frl:6479656
https://doi.org/10.3389/fimmu.2021.665002
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344046/

The Immune Heterogeneity Between Pulmonary Adenocarcinoma and Squamous Cell Carcinoma: A Comprehensive Analysis Based on lncRNA Model

Authors: Yan, Tao Ma, Guoyuan Wang, Kai et al.

Source: Frontiers in immunology, 12:547333

Subject Terms: Carcinoma, Squamous Cell/mortality [MeSH], long non-coding RNAs, Models, Immunological [MeSH], Lung Neoplasms/genetics [MeSH], immune, RNA, Long Noncoding/genetics [MeSH], Risk [MeSH], Cohort Studies [MeSH], squamous cell carcinoma, Adenocarcinoma/immunology [MeSH], Lung Neoplasms/immunology [MeSH], Squamous Cell/immunology [MeSH], Cellular Senescence/genetics [MeSH], Immunity/genetics [MeSH], A549 Cells [MeSH], Immunology, Lung Neoplasms/mortality [MeSH], Long Noncoding/immunology [MeSH], T-Lymphocytes/immunology [MeSH], Humans [MeSH], Survival Analysis [MeSH], Molecular Targeted Therapy [MeSH], adenocarcinoma, Adenocarcinoma/genetics [MeSH], non-small cell lung cancer, Squamous Cell/genetics [MeSH], Adenocarcinoma/mortality [MeSH]

Relation: https://repository.publisso.de/resource/frl:6478835; https://doi.org/10.3389/fimmu.2021.547333; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358782/

Availability: https://repository.publisso.de/resource/frl:6478835
https://doi.org/10.3389/fimmu.2021.547333
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358782/

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report

Authors: Egger, Eva Katharina Ralser, Damian J. Lindner, Kira et al.

Source: Frontiers in immunology, 12:686879

Subject Terms: Receptor, ErbB-2/metabolism [MeSH], Transcription Factors/genetics [MeSH], Antibodies, Monoclonal, Humanized/administration, Immunotherapy [MeSH], DNA-Binding Proteins/genetics [MeSH], vaginal adenocarcinoma, Bevacizumab/administration, Adenocarcinoma/secondary [MeSH], Adenocarcinoma/drug therapy [MeSH], Adenocarcinoma of Lung/genetics [MeSH], Vaginal Neoplasms/secondary [MeSH], Paclitaxel/administration, Female [MeSH], Immunology, Adenocarcinoma of Lung/drug therapy [MeSH], Mutation [MeSH], Vaginal Neoplasms/drug therapy [MeSH], Cisplatin/administration, Humans [MeSH], trastuzumab, Middle Aged [MeSH], abscopal effect, mutational burden, Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], immune checkpoint blockade, Adenocarcinoma/genetics [MeSH], Vaginal Neoplasms/genetics [MeSH]

Relation: https://repository.publisso.de/resource/frl:6477333; https://doi.org/10.3389/fimmu.2021.686879; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342998/

Availability: https://repository.publisso.de/resource/frl:6477333
https://doi.org/10.3389/fimmu.2021.686879
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342998/

Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine

Authors: Röcken, Christoph Amallraja, Anu Halske, Christine et al.

Source: http://lobid.org/resources/99370670445306441#!, 13(1):177.

Subject Terms: Aged, 80 and over [MeSH], Aged [MeSH], B7-H1 Antigen [MeSH], Evolution, Molecular [MeSH], Intratumoral heterogeneity, TP53, Cohort Studies [MeSH], Lymphatic Metastasis [MeSH], SMAD4, Exome [MeSH], Sequence Analysis, DNA [MeSH], Gastric cancer, Stomach Neoplasms/genetics [MeSH], Clonal Evolution [MeSH], Mutation [MeSH], Humans [MeSH], Genetic Heterogeneity [MeSH], Precision Medicine/methods [MeSH], Whole Exome Sequencing [MeSH], Middle Aged [MeSH], Smad4 Protein/genetics [MeSH], Phylogeny [MeSH], Tumor Suppressor Protein p53/genetics [MeSH], DNA Copy Number Variations [MeSH], Targeting cancer evolution in the clinic, Research, Adenocarcinoma/genetics [MeSH]

Relation: https://repository.publisso.de/resource/frl:6465946; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576943/

Availability: https://repository.publisso.de/resource/frl:6465946
https://doi.org/10.1186/s13073-021-00975-y
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576943/

Interferon-lambda (IFNL) germline variations and their significance for HCC and PDAC progression: an analysis of The Cancer Genome Atlas (TCGA) data

Authors: Huschka, Henriette Mihm, Sabine Department of Gastroenterology, Gastrointestinal Oncology, and Endocrinology, University Medical Center Goettingen, Goettingen, Germany

Contributors: Huschka, Henriette Mihm, Sabine Department of Gastroenterology, Gastrointestinal Oncology, and Endocrinology, University Medical Center Goettingen, Goettingen, Germany

Source: BMC Cancer

Subject Terms: Male, 0301 basic medicine, 0303 health sciences, Carcinoma, Hepatocellular, Genome, Interleukins, Liver Neoplasms, Genetic Variation, Adenocarcinoma, 3. Good health, Female [MeSH], Disease Progression [MeSH], Overall survival (OS), Type III interferons, Humans [MeSH], Interferons/metabolism [MeSH], Carcinoma, Hepatocellular/pathology [MeSH], Genetics, genomics and epigenetics, Progression free interval (PFI), Genetic Variation/genetics [MeSH], Pancreatic ductal adenocarcinoma (PDAC), Carcinoma, Pancreatic Ductal/genetics [MeSH], Interleukins/metabolism [MeSH], Liver Neoplasms/pathology [MeSH], Carcinoma, Hepatocellular/genetics [MeSH], Male [MeSH], Hepatocellular carcinoma (HCC), Adenocarcinoma/genetics [MeSH], Antitumor host response, Genome/genetics [MeSH], Liver Neoplasms/genetics [MeSH], Research Article, Germ Cells [MeSH], 03 medical and health sciences, Germ Cells, Disease Progression, Humans, Female, Interferons, 10. No inequality, Carcinoma, Pancreatic Ductal

Access URL: https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-020-07589-4
https://pubmed.ncbi.nlm.nih.gov/33228589
https://link.springer.com/article/10.1186/s12885-020-07589-4
https://link.springer.com/content/pdf/10.1186/s12885-020-07589-4.pdf
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07589-4
https://www.ncbi.nlm.nih.gov/pubmed/33228589
https://europepmc.org/article/PMC/PMC7682090
https://pubmed.ncbi.nlm.nih.gov/33228589/
https://resolver.sub.uni-goettingen.de/purl?gs-1/17671
https://resolver.sub.uni-goettingen.de/purl?gro-2/123182
https://repository.publisso.de/resource/frl:6464653

Nerve fibers in the tumor microenvironment in neurotropic cancer—pancreatic cancer and cholangiocarcinoma

Authors: Tan, Xiuxiang Sivakumar, Shivan Bednarsch, Jan et al.

Source: http://lobid.org/resources/99370678536806441#!, 40(5):899-908.

Subject Terms: Signal Transduction/genetics [MeSH], Adenocarcinoma/therapy [MeSH], Humans [MeSH], Review Article, Cholangiocarcinoma/metabolism [MeSH], Cholangiocarcinoma/therapy [MeSH], Carcinoma, Pancreatic Ductal/genetics [MeSH], Pancreatic Ductal/pathology [MeSH], Cholangiocarcinoma/pathology [MeSH], Adenocarcinoma/pathology [MeSH], Nerve Fibers/pathology [MeSH], Prognosis [MeSH], Adenocarcinoma/genetics [MeSH], Pancreatic Ductal/therapy [MeSH], Nerve Fibers/metabolism [MeSH], Tumor Microenvironment/genetics [MeSH], Combined Modality Therapy [MeSH], Cholangiocarcinoma/genetics [MeSH], Cancer microenvironment, Pancreatic cancer

Relation: https://repository.publisso.de/resource/frl:6471356; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862068/

Availability: https://repository.publisso.de/resource/frl:6471356
https://doi.org/10.1038/s41388-020-01578-4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862068/

Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine

Authors: Christoph Röcken Anu Amallraja Christine Halske et al.

Source: Genome Med
Genome Medicine, Vol 13, Iss 1, Pp 1-19 (2021)
Genome Medicine

Subject Terms: DNA Copy Number Variations, Evolution, Intratumoral heterogeneity, QH426-470, Adenocarcinoma, Aged, 80 and over [MeSH], Aged [MeSH], B7-H1 Antigen [MeSH], Evolution, Molecular [MeSH], TP53, Cohort Studies [MeSH], Lymphatic Metastasis [MeSH], SMAD4, Exome [MeSH], Sequence Analysis, DNA [MeSH], Gastric cancer, Stomach Neoplasms/genetics [MeSH], Clonal Evolution [MeSH], Mutation [MeSH], Humans [MeSH], Genetic Heterogeneity [MeSH], Precision Medicine/methods [MeSH], Whole Exome Sequencing [MeSH], Middle Aged [MeSH], Smad4 Protein/genetics [MeSH], Phylogeny [MeSH], Tumor Suppressor Protein p53/genetics [MeSH], DNA Copy Number Variations [MeSH], Targeting cancer evolution in the clinic, Research, Adenocarcinoma/genetics [MeSH], B7-H1 Antigen, Clonal Evolution, Cohort Studies, Evolution, Molecular, Genetic Heterogeneity, Stomach Neoplasms, Genetics, Humans, Exome, Precision Medicine, Phylogeny, Aged, Smad4 Protein, Aged, 80 and over, Sequence Analysis, DNA, Middle Aged, 3. Good health, Lymphatic Metastasis, Mutation, Medicine, Tumor Suppressor Protein p53

File Description: application/pdf

Access URL: https://europepmc.org/articles/pmc8576943?pdf=render
https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-021-00975-y
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https://www.researchsquare.com/article/rs-62554/v2.pdf?c=1631870597000
https://www.researchsquare.com/article/rs-62554/v1
https://pure.mpg.de/pubman/item/item_3275431_2/component/file_3275432/29970ea0-8bb7-4035-a078-9c4de5e6f16d.pdf
http://hdl.handle.net/21.11116/0000-000A-1585-8
http://hdl.handle.net/21.11116/0000-000A-1587-6
https://repository.publisso.de/resource/frl:6465946