Suchergebnisse - "Acetaminophen"

MiR-743a-3p-mediated hepatic GSTM1 elimination aggravates acetaminophen-induced acute liver injury by inhibiting Sp1 nuclear translocation and SIRT1 expression.

Autoren: Xu TT Pan Y Jin Y et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 301-315. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/adverse effects , Acetaminophen*/toxicity , MicroRNAs*/genetics , MicroRNAs*/metabolism , Sirtuin 1*/genetics , Sirtuin 1*/metabolism , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/genetics , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/etiology , Glutathione Transferase*/genetics , Glutathione Transferase*/metabolism , Sp1 Transcription Factor*/metabolism , Sp1 Transcription Factor*/genetics, Animals ; Mice ; Humans ; Male ; Liver/pathology ; Liver/metabolism ; Liver/drug effects ; Mice, Inbred C57BL ; Oxidative Stress ; Gene Expression Regulation ; Disease Models, Animal

Bavachalcone Protects Against Acetaminophen-Induced Acute Liver Toxicity in Mice by Inhibiting Inflammation and Oxidative Stress Responses.

Autoren: Liu T Sui S An H et al.

Quelle: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Dec; Vol. 39 (12), pp. e70623.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/adverse effects , Acetaminophen*/toxicity , Oxidative Stress*/drug effects , Chalcones*/pharmacology , Chemical and Drug Induced Liver Injury*/prevention & control , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/pathology , Inflammation*/metabolism , Inflammation*/prevention & control , Inflammation*/chemically induced , Inflammation*/drug therapy , Inflammation*/pathology, Animals ; Mice ; Male ; Liver/metabolism ; Liver/pathology ; Liver/drug effects ; Antioxidants/pharmacology

Pharmacokinetics and postoperative analgesic efficacy of intravenous acetaminophen in dogs undergoing laparoscopic ovariohysterectomy.

Autoren: Del Mar Granados M Mengual C Medina-Bautista F et al.

Quelle: Research in veterinary science [Res Vet Sci] 2025 Dec; Vol. 197, pp. 105792. Date of Electronic Publication: 2025 Jul 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/pharmacokinetics , Acetaminophen*/administration & dosage , Acetaminophen*/therapeutic use , Hysterectomy*/veterinary , Pain, Postoperative*/veterinary , Pain, Postoperative*/drug therapy , Ovariectomy*/veterinary , Analgesics, Non-Narcotic*/pharmacokinetics , Analgesics, Non-Narcotic*/administration & dosage , Analgesics, Non-Narcotic*/therapeutic use, Animals ; Dogs/surgery ; Female ; Laparoscopy/veterinary ; Pain Measurement/veterinary ; Administration, Intravenous/veterinary ; Buprenorphine/therapeutic use ; Buprenorphine/pharmacokinetics ; Buprenorphine/administration & dosage

A novel electrochemical sensor based on mixed cubic and spherical Cu 2 O composited with MWCNTs-COOH for sensitive determination of acetaminophen.

Autoren: Zeng JM Zhang J Liu YP et al.

Quelle: Talanta [Talanta] 2025 Dec 01; Vol. 295, pp. 128341. Date of Electronic Publication: 2025 May 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/blood , Acetaminophen*/analysis , Copper*/chemistry , Nanotubes, Carbon*/chemistry , Electrochemical Techniques*/methods , Electrochemical Techniques*/instrumentation, Electrodes ; Humans ; Limit of Detection ; Tablets ; Reproducibility of Results

Paracetamol (acetaminophen) use during pregnancy and autism risk: Evidence does not support causal association.

Autoren: Louwen F Deuster E McAuliffe FM et al.

Quelle: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2025 Dec; Vol. 171 (3), pp. 915-919. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Editorial; Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 0210174 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3479 (Electronic) Linking ISSN: 00207292 NLM ISO Abbreviation: Int J Gynaecol Obstet Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/adverse effects , Acetaminophen*/administration & dosage , Analgesics, Non-Narcotic*/adverse effects , Analgesics, Non-Narcotic*/administration & dosage , Prenatal Exposure Delayed Effects*/chemically induced , Pregnancy Complications*/drug therapy , Autism Spectrum Disorder*/chemically induced , Autism Spectrum Disorder*/epidemiology, Humans ; Pregnancy ; Female

Effect of egg white peptides‑selenium chelate against APAP-induced damage in HepG2 cells and C. elegans via Nrf2 signaling.

Autoren: Wu Y Pei Y Wang W et al.

Quelle: Food chemistry [Food Chem] 2025 Nov 15; Vol. 492 (Pt 2), pp. 145543. Date of Electronic Publication: 2025 Jul 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Caenorhabditis elegans*/drug effects , Caenorhabditis elegans*/metabolism , Caenorhabditis elegans*/genetics , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Peptides*/chemistry , Peptides*/pharmacology , Acetaminophen*/adverse effects , Acetaminophen*/toxicity , Selenium*/chemistry , Selenium*/pharmacology , Chelating Agents*/chemistry , Chelating Agents*/pharmacology , Egg White*/chemistry , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/drug therapy , Chemical and Drug Induced Liver Injury*/genetics , Egg Proteins*/chemistry, Animals ; Humans ; Hep G2 Cells ; Signal Transduction/drug effects ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Reactive Oxygen Species/metabolism ; Oxidative Stress/drug effects

Association between oxycodone-acetaminophen use and acute kidney injury in patients with lower extremity fractures: A retrospective cohort study.

Autoren: Tian C Zhang P Niu G et al.

Quelle: Medicine [Medicine (Baltimore)] 2025 Nov 14; Vol. 104 (46), pp. e45687.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH-Schlagworte: Oxycodone*/adverse effects , Oxycodone*/administration & dosage , Acetaminophen*/adverse effects , Acetaminophen*/administration & dosage , Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/epidemiology , Fractures, Bone*/complications , Analgesics, Opioid*/adverse effects , Analgesics, Opioid*/administration & dosage, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Aged ; Lower Extremity/injuries ; Drug Combinations ; Adult ; Risk Factors

Unveiling the environmental threat of acetaminophen: ecotoxicology, microbial remediation, and molecular modelling insights.

Autoren: Waghmode MS Sahoo DK Patil NN et al.

Quelle: Environmental monitoring and assessment [Environ Monit Assess] 2025 Nov 12; Vol. 197 (12), pp. 1326. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 8508350 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2959 (Electronic) Linking ISSN: 01676369 NLM ISO Abbreviation: Environ Monit Assess Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/toxicity , Acetaminophen*/metabolism , Acetaminophen*/analysis , Environmental Pollutants*/toxicity , Environmental Pollutants*/metabolism , Environmental Restoration and Remediation*/methods, Ecotoxicology ; Biodegradation, Environmental ; Quantitative Structure-Activity Relationship ; Models, Molecular

Effects of a novel acetaminophen analog on cardiorespiratory compensatory responses and survival in a male rat model of traumatic hemorrhage.

Autoren: Pando MM Ryan KL Calderon ML et al.

Quelle: Physiological reports [Physiol Rep] 2025 Nov; Vol. 13 (22), pp. e70619.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/analogs & derivatives , Acetaminophen*/pharmacology , Acetaminophen*/therapeutic use , Hemorrhage*/drug therapy , Hemorrhage*/physiopathology , Analgesics, Non-Narcotic*/pharmacology , Analgesics, Non-Narcotic*/therapeutic use, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Disease Models, Animal ; Heart Rate/drug effects ; Blood Pressure/drug effects

Targeting cuproptosis by FDX1 in acetaminophen-induced liver injury.

Autoren: Liu Y Yang Y Peng B et al.

Quelle: Chemico-biological interactions [Chem Biol Interact] 2025 Nov 01; Vol. 421, pp. 111753. Date of Electronic Publication: 2025 Sep 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/toxicity , Acetaminophen*/adverse effects , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/drug therapy , Copper*/metabolism, Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Male ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Molybdenum/pharmacology ; Molybdenum/therapeutic use ; Liver/pathology ; Liver/drug effects ; Liver/metabolism ; Cell Line

Studying APAP metabolism in a cohort of intoxicated patients using HRMS-based profiling: Detection of catechol and delayed thiomethyl metabolites.

Autoren: Gicquel T Pelletier R Gorrochategui E et al.

Quelle: Toxicology letters [Toxicol Lett] 2025 Nov; Vol. 413, pp. 111727. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/blood , Acetaminophen*/metabolism , Acetaminophen*/pharmacokinetics , Acetaminophen*/poisoning , Catechols*/blood , Chemical and Drug Induced Liver Injury*/blood , Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/diagnosis , Analgesics, Non-Narcotic*/blood , Analgesics, Non-Narcotic*/pharmacokinetics, Humans ; Male ; Female ; Biomarkers/blood ; Adult ; Middle Aged ; Drug Overdose/blood ; Benzoquinones/blood ; Benzoquinones/metabolism ; Mass Spectrometry ; Cohort Studies ; Imines/blood ; Biotransformation

Acetaminophen pharmacobezoar following a massive suicidal ingestion.

Autoren: Steckler T Blanchot A Gheddar L et al.

Quelle: Journal of forensic sciences [J Forensic Sci] 2025 Nov; Vol. 70 (6), pp. 2594-2599. Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: Blackwell Pub Country of Publication: United States NLM ID: 0375370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-4029 (Electronic) Linking ISSN: 00221198 NLM ISO Abbreviation: J Forensic Sci Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/poisoning , Acetaminophen*/analysis , Bezoars*/diagnostic imaging , Bezoars*/pathology , Suicide, Completed* , Analgesics, Non-Narcotic*/poisoning, Humans ; Female ; Middle Aged ; Tomography, X-Ray Computed ; Forensic Toxicology

Sonochemically enhanced activated charcoal with improved oral palatability for efficient in vitro detoxification of acetaminophen.

Autoren: Riahimanesh F Alahabadi A Salari M et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 27; Vol. 15 (1), pp. 37476. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Charcoal*/chemistry , Acetaminophen*/chemistry , Acetaminophen*/toxicity, Adsorption ; Administration, Oral ; Hydrogen-Ion Concentration ; Humans ; Inactivation, Metabolic

Effect of the intravenous acetaminophen clinical pathway on postoperative analgesia in spinal fusion surgery.

Autoren: Taniguchi H Fukuda K Sato T et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 21; Vol. 15 (1), pp. 36644. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/administration & dosage , Acetaminophen*/therapeutic use , Pain, Postoperative*/drug therapy , Pain, Postoperative*/etiology , Spinal Fusion*/adverse effects , Spinal Fusion*/methods , Analgesics, Non-Narcotic*/administration & dosage , Analgesics, Non-Narcotic*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Adult ; Administration, Intravenous ; Critical Pathways ; Pain Measurement ; Pain Management/methods ; Analgesia/methods

Effect of acetaminophen on the short-term mortality of hospitalized patients with hypertension: A retrospective cohort study.

Autoren: Liu JY Xie B Zhou YF et al.

Quelle: Medicine [Medicine (Baltimore)] 2025 Oct 03; Vol. 104 (40), pp. e44744.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/therapeutic use , Acetaminophen*/adverse effects , Acetaminophen*/administration & dosage , Hypertension*/mortality , Hypertension*/drug therapy , Hospital Mortality* , Analgesics, Non-Narcotic*/therapeutic use , Analgesics, Non-Narcotic*/adverse effects , Analgesics, Non-Narcotic*/administration & dosage, Humans ; Retrospective Studies ; Female ; Male ; Middle Aged ; Aged ; Propensity Score ; Hospitalization ; Proportional Hazards Models

Characterization of behavioral and emotional responses of male and female juvenile rats in the orofacial formalin test following acetaminophen treatment.

Autoren: Saurin YNT Dos Reis RC Baggio DF et al.

Quelle: Behavioural brain research [Behav Brain Res] 2025 Oct 02; Vol. 494, pp. 115748. Date of Electronic Publication: 2025 Jul 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/pharmacology , Acetaminophen*/administration & dosage , Behavior, Animal*/drug effects , Analgesics, Non-Narcotic*/pharmacology , Facial Pain*/drug therapy , Facial Pain*/chemically induced , Facial Pain*/physiopathology , Emotions*/drug effects, Animals ; Male ; Female ; Rats, Wistar ; Rats ; Vocalization, Animal/drug effects ; Disease Models, Animal ; Formaldehyde/pharmacology ; Pain Measurement ; Nociception/drug effects ; Locomotion/drug effects

Paracetamol (N-acetyl-para-aminophenol) disrupts early embryogenesis by cell cycle inhibition.

Autoren: Nielsen BS Petersen MR Martin-Gonzalez J et al.

Quelle: Human reproduction (Oxford, England) [Hum Reprod] 2025 Oct 01; Vol. 40 (10), pp. 1860-1876.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print Cited Medium: Internet ISSN: 1460-2350 (Electronic) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/pharmacology , Acetaminophen*/adverse effects , Embryonic Development*/drug effects , Cell Cycle*/drug effects, Humans ; Female ; Animals ; Mice ; Blastocyst/drug effects ; Pregnancy ; Adult

Trends in Fomepizole Use for Acetaminophen Poisoning in the United States; 2013-2024.

Autoren: D'Aloia M Smith D Boley R et al.

Quelle: Journal of medical toxicology : official journal of the American College of Medical Toxicology [J Med Toxicol] 2025 Oct; Vol. 21 (4), pp. 404-408. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 101284598 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-6995 (Electronic) Linking ISSN: 15569039 NLM ISO Abbreviation: J Med Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/poisoning , Fomepizole*/therapeutic use , Antidotes*/therapeutic use , Analgesics, Non-Narcotic*/poisoning , Practice Patterns, Physicians'*/trends, Humans ; Male ; Female ; United States/epidemiology ; Cross-Sectional Studies ; Middle Aged ; Adult ; Acetylcysteine/therapeutic use ; Young Adult ; Aged ; Adolescent ; Databases, Factual ; Chemical and Drug Induced Liver Injury/mortality ; Treatment Outcome

Hepatoprotective Activity of Red Ginger Extract on Acetaminophen-induced Liver Injury Models in HepG2 Cells.

Autoren: Widowati W Kusuma HSW Priyandoko D et al.

Quelle: Annals of African medicine [Ann Afr Med] 2025 Oct 01; Vol. 24 (4), pp. 712-720. Date of Electronic Publication: 2025 Jun 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Medknow Publications Country of Publication: India NLM ID: 101231417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0975-5764 (Electronic) Linking ISSN: 09755764 NLM ISO Abbreviation: Ann Afr Med Subsets: MEDLINE

MeSH-Schlagworte: Acetaminophen*/toxicity , Acetaminophen*/adverse effects , Plant Extracts*/pharmacology , Zingiber officinale*/chemistry , Chemical and Drug Induced Liver Injury*/prevention & control , Chemical and Drug Induced Liver Injury*/drug therapy , Liver*/drug effects , Liver*/metabolism, Humans ; Hep G2 Cells/drug effects ; Nitric Oxide/metabolism ; L-Lactate Dehydrogenase/metabolism ; Interleukin-1beta/metabolism

Alizarin Mitigates Paracetamol-Induced Hepatorenal Injury in Mice via Modulation of the Nrf2/HO-1/NFκB/Apoptosis Pathway.

Autoren: Zemheri-Navruz F Demirel HH Cesur S et al.

Quelle: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Dec; Vol. 39 (12), pp. e70610.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

MeSH-Schlagworte: NF-E2-Related Factor 2*/metabolism , Acetaminophen*/adverse effects , Acetaminophen*/toxicity , Apoptosis*/drug effects , Anthraquinones*/pharmacology , NF-kappa B*/metabolism , Signal Transduction*/drug effects , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/drug therapy , Chemical and Drug Induced Liver Injury*/prevention & control , Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/metabolism , Heme Oxygenase-1*/metabolism, Animals ; Mice ; Male ; Kidney/metabolism ; Kidney/pathology ; Kidney/drug effects ; Liver/metabolism ; Liver/drug effects ; Liver/pathology ; Oxidative Stress/drug effects ; Membrane Proteins