Suchergebnisse - "APOPTOSIS"

Novel tetravalent bispecific antibody, PSMA/TRAIL‑R2 REGULGENT™, induces selective tumor cell apoptosis without hepatotoxicity.

Autoren: Nakayama M Takagi-Maeda S Machino Y et al.

Quelle: Oncology reports [Oncol Rep] 2025 Nov; Vol. 54 (5). Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Bispecific*/pharmacology , Receptors, TNF-Related Apoptosis-Inducing Ligand*/immunology , Receptors, TNF-Related Apoptosis-Inducing Ligand*/antagonists & inhibitors , Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism , Glutamate Carboxypeptidase II*/immunology , Glutamate Carboxypeptidase II*/antagonists & inhibitors , Antigens, Surface*/immunology , Prostatic Neoplasms*/drug therapy , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/immunology, Humans ; Animals ; Apoptosis/drug effects ; Mice ; Male ; Xenograft Model Antitumor Assays ; Cell Line, Tumor

Antineoplastic Activity of a Novel Trispecific Single-Chain Antibody Targeting the hERG1/β1 Integrin Complex and TRAIL Receptors.

Autoren: Duranti C Iorio J Capitani C et al.

Quelle: Molecular cancer therapeutics [Mol Cancer Ther] 2025 Oct 01; Vol. 24 (10), pp. 1584-1599.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

MeSH-Schlagworte: Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism , Receptors, TNF-Related Apoptosis-Inducing Ligand*/antagonists & inhibitors , Integrin beta1*/metabolism , Integrin beta1*/immunology , Single-Chain Antibodies*/pharmacology , Ether-A-Go-Go Potassium Channels*/immunology , Ether-A-Go-Go Potassium Channels*/antagonists & inhibitors , Ether-A-Go-Go Potassium Channels*/metabolism , Antineoplastic Agents*/pharmacology, Humans ; Animals ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Female ; Apoptosis/drug effects ; ERG1 Potassium Channel ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/pathology

TRAIL-resistant glioma cells resist Withania somnifera mediated apoptosis via USP5 upregulation.

Autoren: Bhardwaj S Yadav AK

Quelle: Scientific reports [Sci Rep] 2025 Oct 01; Vol. 15 (1), pp. 34133. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: TNF-Related Apoptosis-Inducing Ligand*/pharmacology , TNF-Related Apoptosis-Inducing Ligand*/metabolism , Apoptosis*/drug effects , Glioma*/drug therapy , Glioma*/metabolism , Glioma*/pathology , Glioma*/genetics , Withania*/chemistry , Drug Resistance, Neoplasm*/drug effects , Plant Extracts*/pharmacology , Brain Neoplasms*/drug therapy , Brain Neoplasms*/metabolism , Brain Neoplasms*/pathology , Endopeptidases*/metabolism , Endopeptidases*/genetics, Humans ; Cell Line, Tumor ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; Up-Regulation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation, Neoplastic/drug effects

The efficacy of hyperthermia-based multimodal therapy is dependent on gatekeeper protein, BID.

Autoren: Helmueller S Song X Kim DH et al.

Quelle: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2025 Dec; Vol. 42 (1), pp. 2544017. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8508395 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5157 (Electronic) Linking ISSN: 02656736 NLM ISO Abbreviation: Int J Hyperthermia Subsets: MEDLINE

MeSH-Schlagworte: BH3 Interacting Domain Death Agonist Protein*/metabolism , BH3 Interacting Domain Death Agonist Protein*/genetics , Hyperthermia, Induced*/methods , TNF-Related Apoptosis-Inducing Ligand*/pharmacology , TNF-Related Apoptosis-Inducing Ligand*/therapeutic use, Humans ; Combined Modality Therapy ; Artesunate ; Cell Line, Tumor ; Apoptosis/drug effects ; Colonic Neoplasms/therapy

The multifaceted role of PUMA in cell death pathways: its therapeutic potential across cancer types.

Autoren: Tat SS Mandal K Sharma T et al.

Quelle: Cell communication and signaling : CCS [Cell Commun Signal] 2025 Nov 20; Vol. 23 (1), pp. 499. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/pathology , Neoplasms*/metabolism , Neoplasms*/genetics , Neoplasms*/drug therapy , Apoptosis Regulatory Proteins*/metabolism , Apoptosis Regulatory Proteins*/genetics , Proto-Oncogene Proteins*/metabolism , Proto-Oncogene Proteins*/genetics , Signal Transduction* , Cell Death*, Humans ; Animals ; Apoptosis ; Epigenesis, Genetic

Chrysin Attenuates Myocardial Cell Apoptosis in Mice.

Autoren: Deng G Yang Y Qing O et al.

Quelle: Cardiovascular toxicology [Cardiovasc Toxicol] 2025 Nov; Vol. 25 (11), pp. 1791-1806. Date of Electronic Publication: 2025 Sep 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 101135818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0259 (Electronic) Linking ISSN: 15307905 NLM ISO Abbreviation: Cardiovasc Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Flavonoids*/pharmacology , Apoptosis*/drug effects , Myocytes, Cardiac*/drug effects , Myocytes, Cardiac*/pathology , Myocytes, Cardiac*/metabolism , Myocardial Infarction*/pathology , Myocardial Infarction*/metabolism , Myocardial Infarction*/prevention & control , Myocardial Infarction*/physiopathology , Myocardial Infarction*/drug therapy , Myocardial Reperfusion Injury*/pathology , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/prevention & control , Myocardial Reperfusion Injury*/physiopathology, Animals ; Disease Models, Animal ; Male ; Signal Transduction ; Mice, Inbred C57BL ; Fibrosis ; Apoptosis Regulatory Proteins/metabolism ; Apoptosis Regulatory Proteins/genetics ; Ventricular Function, Left/drug effects ; Ventricular Remodeling/drug effects ; Cells, Cultured ; Caspase 3

Hemilineage-specific deployment of the pro-apoptotic RHG genes reaper and grim during neurogenesis sculpts segment and sex-specific neural network composition in Drosophila.

Autoren: Sproston CJ Rak JE Marin EC et al.

Quelle: Development (Cambridge, England) [Development] 2025 Nov 01; Vol. 152 (21). Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE

MeSH-Schlagworte: Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism , Neurogenesis*/genetics , Neurogenesis*/physiology , Apoptosis Regulatory Proteins*/genetics , Apoptosis Regulatory Proteins*/metabolism , Nerve Net*/metabolism , Nerve Net*/embryology , Nerve Net*/cytology , Drosophila*/embryology , Drosophila*/genetics , Drosophila melanogaster*/embryology , Drosophila melanogaster*/genetics, Animals ; Female ; Male ; Gene Expression Regulation, Developmental ; Apoptosis/genetics ; Neurons/cytology ; Neurons/metabolism ; Cell Lineage ; Sex Characteristics ; Neuropeptides

Baculovirus-Mediated Gene Therapy: Targeting BIRC6 for Lung and Breast Cancer.

Autoren: Marchesini A Gómez Bergna SM Amorós Morales LC et al.

Quelle: Viruses [Viruses] 2025 Oct 31; Vol. 17 (11). Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Inhibitor of Apoptosis Proteins*/genetics , Inhibitor of Apoptosis Proteins*/metabolism , Lung Neoplasms*/therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Baculoviridae*/genetics , Genetic Therapy*/methods, Humans ; Female ; Animals ; Apoptosis/genetics ; Cell Line, Tumor ; Mice ; RNA, Small Interfering/genetics ; RNA Interference

Role of microRNA-761 in modulating laryngeal cancer cell proliferation, metastasis, and apoptosis: regulation of PDCD4 as a key mechanism.

Autoren: Chen R Wang Z Wu B et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Oct 17; Vol. 52 (1), pp. 1039. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: MicroRNAs*/genetics , MicroRNAs*/metabolism , Laryngeal Neoplasms*/genetics , Laryngeal Neoplasms*/pathology , Laryngeal Neoplasms*/metabolism , Apoptosis Regulatory Proteins*/genetics , Apoptosis Regulatory Proteins*/metabolism , RNA-Binding Proteins*/genetics , RNA-Binding Proteins*/metabolism, Humans ; Cell Proliferation/genetics ; Apoptosis/genetics ; Animals ; Gene Expression Regulation, Neoplastic/genetics ; Cell Line, Tumor ; Mice ; Cell Movement/genetics ; Male ; Female ; Mice, Nude ; Signal Transduction/genetics ; 3' Untranslated Regions ; Neoplasm Metastasis ; Xenograft Model Antitumor Assays ; Middle Aged

PDCD4: A critical regulator in leukemic signaling networks and its therapeutic potential.

Autoren: Huang J Yin M Zhang R et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Dec 06; Vol. 53 (1), pp. 167. Date of Electronic Publication: 2025 Dec 06.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Apoptosis Regulatory Proteins*/metabolism , Apoptosis Regulatory Proteins*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Signal Transduction* , Leukemia*/metabolism , Leukemia*/genetics , Leukemia*/pathology, Humans ; Apoptosis/genetics ; Cell Proliferation ; Animals ; Gene Expression Regulation, Leukemic

DR5 CAR-NK cells demonstrate superior scalability and potent antitumor activity with favorable safety.

Autoren: Chen Q Xia M Tang M et al.

Quelle: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6063-6081. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH-Schlagworte: Killer Cells, Natural*/immunology , Killer Cells, Natural*/metabolism , Killer Cells, Natural*/transplantation , Receptors, Chimeric Antigen*/genetics , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/metabolism , Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics , Receptors, TNF-Related Apoptosis-Inducing Ligand*/immunology , Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism , Immunotherapy, Adoptive*/methods , Neoplasms*/therapy , Neoplasms*/immunology, Animals ; Humans ; Mice ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Apoptosis ; Genetic Vectors/genetics

Prognostic and immunological potential of AC012236.1/hsa-miR-30d-5p CeRNA of AVEN by integrated analysis of single-cell and bulk RNA-seq in lung adenocarcinoma.

Autoren: Yin R Dong X Guo Z et al.

Quelle: Scientific reports [Sci Rep] 2025 Dec 01; Vol. 15 (1), pp. 42863. Date of Electronic Publication: 2025 Dec 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/immunology , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/mortality , Lung Neoplasms*/genetics , Lung Neoplasms*/immunology , Lung Neoplasms*/pathology , Lung Neoplasms*/mortality , MicroRNAs*/genetics , Apoptosis Regulatory Proteins*/genetics , Apoptosis Regulatory Proteins*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , Membrane Proteins*/genetics, Humans ; Prognosis ; Gene Expression Regulation, Neoplastic ; Female ; Male ; Single-Cell Analysis ; Biomarkers, Tumor/genetics ; Tumor Microenvironment/immunology ; Middle Aged ; RNA-Seq ; Cell Line, Tumor ; RNA, Competitive Endogenous ; Neoplasm Proteins ; Inhibitor of Apoptosis Proteins

The role and mechanism of autophagy-regulated Keap1/Nrf2 pathway in oxidative stress-induced cartilage endplate cell apoptosis.

Autoren: Wang W Deng K Chen W et al.

Quelle: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112153. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Autophagy*/drug effects , Oxidative Stress*/drug effects , Apoptosis*/drug effects , Signal Transduction*/drug effects , Intervertebral Disc Degeneration*/pathology , Intervertebral Disc Degeneration*/metabolism, Animals ; Kelch-Like ECH-Associated Protein 1/metabolism ; Rats ; Humans ; Beclin-1 ; Male ; Rats, Sprague-Dawley ; Female ; Chondrocytes/metabolism ; Chondrocytes/drug effects ; Middle Aged ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/toxicity ; Apoptosis Regulatory Proteins/metabolism ; Adenine/analogs & derivatives ; Adenine/pharmacology

Current approaches to overcome the limit of TRAIL-based treatment in colorectal cancer: From fusion protein to nano-delivery platform.

Autoren: Chen X Yang X Yi C et al.

Quelle: International journal of pharmaceutics [Int J Pharm] 2025 Oct 15; Vol. 683, pp. 126031. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

MeSH-Schlagworte: TNF-Related Apoptosis-Inducing Ligand*/administration & dosage , Colorectal Neoplasms*/drug therapy , Antineoplastic Agents*/administration & dosage, Humans ; Animals ; Apoptosis/drug effects ; Nanoparticles ; Recombinant Fusion Proteins/administration & dosage ; Drug Delivery Systems

FAIM modulates HCC progression via enhancing HMGA1 interaction with CDK7 and promoting its phosphorylation level.

Autoren: Li Y Liu W Fan X et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Oct 15; Vol. 23 (1), pp. 1099. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Cyclin-Dependent Kinases*/metabolism , Disease Progression* , HMGA1a Protein*/metabolism , Apoptosis Regulatory Proteins*/metabolism, Phosphorylation ; Humans ; Animals ; Male ; Cell Line, Tumor ; Mice, Inbred BALB C ; Cyclin-Dependent Kinase-Activating Kinase ; Protein Binding ; Cell Proliferation ; Apoptosis ; Mice

Identification of a New Interesting BAG3 Modulator Able to Disrupt Cancer-Related Pathways.

Autoren: Ruggiero D Boccia E Ingenito E et al.

Quelle: ChemMedChem [ChemMedChem] 2025 Oct 15; Vol. 20 (20), pp. e202500310. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , Apoptosis Regulatory Proteins*/metabolism , Apoptosis Regulatory Proteins*/antagonists & inhibitors , Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis, Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Neoplasms/drug therapy ; Neoplasms/metabolism

TIGAR deficiency exacerbated preeclampsia by impairing autophagy and accelerating trophoblasts apoptosis upon excessive oxidative stress via the NRF2-ARE pathway.

Autoren: Guo J Zhou M Li S et al.

Quelle: Life sciences [Life Sci] 2025 Dec 15; Vol. 383, pp. 124062. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Trophoblasts*/metabolism , Trophoblasts*/pathology , NF-E2-Related Factor 2*/metabolism , Oxidative Stress*/physiology , Pre-Eclampsia*/metabolism , Pre-Eclampsia*/pathology , Apoptosis*/physiology , Autophagy*/physiology , Phosphoric Monoester Hydrolases*/deficiency , Phosphoric Monoester Hydrolases*/metabolism, Female ; Pregnancy ; Humans ; Animals ; Mice ; Signal Transduction ; Hydrogen Peroxide ; Apoptosis Regulatory Proteins ; Antioxidant Response Elements ; Adult ; Placenta/metabolism

Survivin targeting triple-fusion vaccine DC Survivin-LTB inhibits tumor growth in mouse model of triple-negative breast cancer.

Autoren: Rashid A Krishnan A Gupta S et al.

Quelle: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Dec 04; Vol. 43 (1), pp. 35. Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

MeSH-Schlagworte: Survivin*/immunology , Cancer Vaccines*/immunology , Cancer Vaccines*/pharmacology , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/therapy , Dendritic Cells*/immunology , Inhibitor of Apoptosis Proteins*/immunology, Animals ; Female ; Mice ; Mice, Inbred BALB C ; Cell Line, Tumor ; Humans ; Disease Models, Animal ; Apoptosis

Cytogenotoxic Activity of Gadoteric Acid in SH-SY5Y Cells and XIAP Interaction With Molecular Docking.

Autoren: Bilgin B Husunet MT Kenger IH

Quelle: Journal of applied toxicology : JAT [J Appl Toxicol] 2025 Nov; Vol. 45 (11), pp. 2450-2457. Date of Electronic Publication: 2025 Aug 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE

MeSH-Schlagworte: X-Linked Inhibitor of Apoptosis Protein*/metabolism , Contrast Media*/toxicity , Neuroblastoma*/pathology , Organometallic Compounds*/toxicity, Humans ; Molecular Docking Simulation ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Damage/drug effects ; Apoptosis/drug effects ; Comet Assay

Centipede Polypeptide Affects the Inflammatory Reaction and Ferroptosis of Liver Cancer Cells Through the p53/TRAIL Pathway.

Autoren: Xing X Lu L Huang Z et al.

Quelle: Journal of cellular and molecular medicine [J Cell Mol Med] 2025 Oct; Vol. 29 (19), pp. e70844.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

MeSH-Schlagworte: Tumor Suppressor Protein p53*/metabolism , Tumor Suppressor Protein p53*/genetics , TNF-Related Apoptosis-Inducing Ligand*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Liver Neoplasms*/drug therapy , Signal Transduction*/drug effects , Ferroptosis*/drug effects , Peptides*/pharmacology , Peptides*/chemistry , Inflammation*/pathology , Inflammation*/drug therapy , Inflammation*/metabolism, Humans ; Animals ; Hep G2 Cells ; Mice ; Molecular Docking Simulation ; Mice, Nude ; Apoptosis/drug effects ; Male