Výsledky vyhľadávania - "ANXIETY"

Associated factors to Generalized Anxiety in a sample of women screened for the risk of perinatal depression: a naturalistic study from Italy.

Autori: Ventriglio A Severo M Petito A a ďalší

Zdroj: Journal of affective disorders [J Affect Disord] 2025 Oct 01; Vol. 386, pp. 119474. Date of Electronic Publication: 2025 May 24.

Spôsob vydávania: Journal Article; Multicenter Study

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anxiety Disorders*/epidemiology , Anxiety Disorders*/psychology , Anxiety Disorders*/diagnosis , Depression, Postpartum*/psychology , Depression, Postpartum*/epidemiology , Depression, Postpartum*/diagnosis , Pregnancy Complications*/psychology , Pregnancy Complications*/epidemiology , Anxiety*/psychology , Anxiety*/epidemiology , Depression*/epidemiology , Depression*/psychology , Depression*/diagnosis, Humans ; Female ; Italy/epidemiology ; Adult ; Pregnancy ; Quality of Life/psychology ; Adaptation, Psychological ; Risk Factors ; Young Adult ; Psychiatric Status Rating Scales ; Resilience, Psychological ; Generalized Anxiety Disorder

The role of self-control in the bidirectional relation between problematic smartphone use and generalized anxiety symptoms among depressed secondary school students: Insight from longitudinal moderation network analysis.

Autori: Lu X Zhang L Tao Y

Zdroj: Journal of affective disorders [J Affect Disord] 2025 Dec 15; Vol. 391, pp. 119981. Date of Electronic Publication: 2025 Jul 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

Výrazy zo slovníka MeSH: Self-Control*/psychology , Smartphone* , Students*/psychology , Depressive Disorder, Major*/psychology , Depressive Disorder, Major*/epidemiology , Internet Addiction Disorder*/psychology , Internet Addiction Disorder*/epidemiology , Anxiety Disorders*/psychology , Anxiety*/psychology, Humans ; Female ; Male ; Adolescent ; Surveys and Questionnaires ; Longitudinal Studies ; Schools ; Generalized Anxiety Disorder

An updated systematic review and meta-analysis of the predictive validity of the general anxiety disorder (GAD)-7 and GAD-2 in screening for anxiety disorders.

Autori: Park SH Park SK

Zdroj: Journal of affective disorders [J Affect Disord] 2025 Dec 15; Vol. 391, pp. 119913. Date of Electronic Publication: 2025 Jul 14.

Spôsob vydávania: Journal Article; Meta-Analysis; Systematic Review

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anxiety Disorders*/diagnosis , Anxiety Disorders*/psychology , Psychiatric Status Rating Scales*, Humans ; Generalized Anxiety Disorder ; Mass Screening ; Predictive Value of Tests ; Reproducibility of Results ; Sensitivity and Specificity

Ambroxol's Role in PTZ-Induced Anxiety-Like Conditions in Mice: Targeting Neuroinflammation and Oxidative Stress via In Vivo and In Silico Approaches.

Autori: Ali HZ Jahan S Ilahi L a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 24; Vol. 63 (1), pp. 162. Date of Electronic Publication: 2025 Nov 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxidative Stress*/drug effects , Ambroxol*/pharmacology , Ambroxol*/therapeutic use , Anxiety*/drug therapy , Anxiety*/chemically induced , Anxiety*/metabolism , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/metabolism , Computer Simulation*, Animals ; Mice ; Male ; Pentylenetetrazole ; Molecular Docking Simulation ; Anti-Anxiety Agents/pharmacology ; Anti-Anxiety Agents/therapeutic use ; Antioxidants ; Diazepam/pharmacology ; Behavior, Animal/drug effects ; Disease Models, Animal ; Cytokines/metabolism

Long-term occupational outcomes in major depressive disorder: a 10-year follow-up study of symptom and comorbidity predictors.

Autori: Hung CI Wu KY Wang LY a ďalší

Zdroj: BMC psychiatry [BMC Psychiatry] 2025 Nov 03; Vol. 25 (1), pp. 1050. Date of Electronic Publication: 2025 Nov 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Depressive Disorder, Major*/epidemiology , Depressive Disorder, Major*/psychology , Depressive Disorder, Major*/diagnosis , Employment*/statistics & numerical data , Employment*/psychology , Anxiety Disorders*/epidemiology , Anxiety Disorders*/psychology, Humans ; Female ; Male ; Follow-Up Studies ; Adult ; Comorbidity ; Middle Aged ; Anxiety/epidemiology ; Anxiety/psychology

Anxiolytic effects of clemastine via modulation of hippocampal oligodendrocytes in a mouse model of methotrexate-induced cognitive impairment.

Autori: Ochi R Yamada J Iinuma KM a ďalší

Zdroj: Neuropharmacology [Neuropharmacology] 2025 Nov 01; Vol. 278, pp. 110589. Date of Electronic Publication: 2025 Jul 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Methotrexate*/toxicity , Hippocampus*/drug effects , Hippocampus*/metabolism , Oligodendroglia*/drug effects , Oligodendroglia*/metabolism , Anti-Anxiety Agents*/pharmacology , Anti-Anxiety Agents*/therapeutic use , Cognitive Dysfunction*/chemically induced , Cognitive Dysfunction*/drug therapy , Chemotherapy-Related Cognitive Impairment*/drug therapy, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Anxiety/drug therapy ; Anxiety/chemically induced ; Disease Models, Animal ; Antimetabolites, Antineoplastic/toxicity ; Maze Learning/drug effects

Common and disorder-specific neural activity and connectivity in generalized anxiety, panic, and social anxiety disorders.

Autori: Xiao H Yuan M Cao Y a ďalší

Zdroj: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2025 Oct 02; Vol. 35 (10).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE

Výrazy zo slovníka MeSH: Panic Disorder*/physiopathology , Panic Disorder*/diagnostic imaging , Phobia, Social*/physiopathology , Phobia, Social*/diagnostic imaging , Anxiety Disorders*/physiopathology , Anxiety Disorders*/diagnostic imaging , Brain*/physiopathology , Brain*/diagnostic imaging , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging, Humans ; Male ; Female ; Adult ; Magnetic Resonance Imaging ; Neural Pathways/physiopathology ; Neural Pathways/diagnostic imaging ; Young Adult ; Brain Mapping ; Middle Aged ; Generalized Anxiety Disorder

A cannabidiol (CBD) lipid-based nanoemulsion induces anxiolytic- and panicolytic-like effects and increases FosB/deltaFosB immunoreactivity in serotonergic cells of the dorsal raphe.

Autori: Rosário BA de Lima MP Vieira MG Jr a ďalší

Zdroj: Brain research [Brain Res] 2025 Oct 01; Vol. 1864, pp. 149791. Date of Electronic Publication: 2025 Jun 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cannabidiol*/pharmacology , Cannabidiol*/administration & dosage , Proto-Oncogene Proteins c-fos*/metabolism , Anti-Anxiety Agents*/pharmacology , Anti-Anxiety Agents*/administration & dosage , Serotonergic Neurons*/drug effects , Serotonergic Neurons*/metabolism , Dorsal Raphe Nucleus*/drug effects , Dorsal Raphe Nucleus*/metabolism, Animals ; Male ; Rats, Wistar ; Rats ; Anxiety/drug therapy ; Anxiety/metabolism ; Emulsions ; Periaqueductal Gray/metabolism ; Periaqueductal Gray/drug effects ; Serotonin/metabolism

Prevalence, correlates, and treatment gap of generalized anxiety disorder among adults in Bangladesh: Results from a nationally representative survey.

Autori: Sarkar AA Alam MF Ahmed HU a ďalší

Zdroj: Journal of anxiety disorders [J Anxiety Disord] 2025 Dec; Vol. 116, pp. 103077. Date of Electronic Publication: 2025 Oct 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8710131 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7897 (Electronic) Linking ISSN: 08876185 NLM ISO Abbreviation: J Anxiety Disord Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anxiety Disorders*/epidemiology , Anxiety Disorders*/therapy , Anxiety Disorders*/diagnosis, Humans ; Bangladesh/epidemiology ; Male ; Female ; Adult ; Prevalence ; Middle Aged ; Young Adult ; Adolescent ; Rural Population/statistics & numerical data ; Health Surveys ; Urban Population/statistics & numerical data ; Aged ; Generalized Anxiety Disorder

Youth with ADHD, autism or comorbid ADHD and autism in Iceland: Comparisons of attentional and cognitive profiles and the effects of anxiety on cognitive performance.

Autori: Ingadottir TR Jonsdottir H Jarrett MA a ďalší

Zdroj: Research in developmental disabilities [Res Dev Disabil] 2025 Dec; Vol. 167, pp. 105142. Date of Electronic Publication: 2025 Nov 03.

Spôsob vydávania: Journal Article; Comparative Study

Informácie o časopise: Publisher: Pergamon Press Country of Publication: United States NLM ID: 8709782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3379 (Electronic) Linking ISSN: 08914222 NLM ISO Abbreviation: Res Dev Disabil Subsets: MEDLINE

Výrazy zo slovníka MeSH: Attention Deficit Disorder with Hyperactivity*/epidemiology , Attention Deficit Disorder with Hyperactivity*/psychology , Autism Spectrum Disorder*/epidemiology , Autism Spectrum Disorder*/psychology , Cognition* , Anxiety Disorders*/epidemiology , Anxiety Disorders*/psychology , Attention*, Humans ; Child ; Iceland/epidemiology ; Male ; Female ; Adolescent ; Comorbidity ; Wechsler Scales ; Anxiety/psychology ; Neuropsychological Tests

Trauma echoes: factors associated with peritraumatic distress and anxiety five days following Iranian missile attack on Israel.

Autori: Ben-David BM Bressler TE Ring L a ďalší

Zdroj: European journal of psychotraumatology [Eur J Psychotraumatol] 2025 Dec; Vol. 16 (1), pp. 2446070. Date of Electronic Publication: 2025 Jan 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101559025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2000-8066 (Electronic) Linking ISSN: 20008066 NLM ISO Abbreviation: Eur J Psychotraumatol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Stress Disorders, Post-Traumatic*/epidemiology , Anxiety Disorders*/epidemiology, Humans ; Israel/epidemiology ; Female ; Male ; Iran ; Middle Aged ; Adult ; Prevalence ; Anxiety/epidemiology ; Anxiety/psychology ; Aged, 80 and over ; Aged

Adapting digital anxiety treatments to reduce anorexia nervosa relapse.

Autori: Levinson CA Fitterman-Harris HF McCarthy A a ďalší

Zdroj: Journal of affective disorders [J Affect Disord] 2025 Dec 01; Vol. 390, pp. 119842. Date of Electronic Publication: 2025 Jul 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anorexia Nervosa*/psychology , Anorexia Nervosa*/therapy , Anorexia Nervosa*/prevention & control , Anxiety Disorders*/therapy , Anxiety Disorders*/psychology , Anxiety Disorders*/diagnosis , Implosive Therapy*/methods, Humans ; Female ; Recurrence ; Adult ; Anxiety/therapy ; Fear/psychology ; Secondary Prevention

Reduced coupling between global signal and cerebrospinal fluid inflow in patients with generalized anxiety disorder: A resting state functional MRI study.

Autori: Qian R Wang L Fan S a ďalší

Zdroj: Journal of affective disorders [J Affect Disord] 2025 Dec 01; Vol. 390, pp. 119851. Date of Electronic Publication: 2025 Jul 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anxiety Disorders*/physiopathology , Anxiety Disorders*/cerebrospinal fluid , Anxiety Disorders*/psychology , Glymphatic System*/physiopathology , Brain*/physiopathology, Humans ; Male ; Female ; Magnetic Resonance Imaging ; Adult ; Middle Aged ; Young Adult ; Generalized Anxiety Disorder

Disruption of brain regional homogeneity and functional connectivity in patients with generalized anxiety disorder: A resting-state fMRI study.

Autori: Chen F Xia L Dong M a ďalší

Zdroj: Neuroscience [Neuroscience] 2025 Nov 28; Vol. 589, pp. 280-287. Date of Electronic Publication: 2025 Oct 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anxiety Disorders*/physiopathology , Anxiety Disorders*/diagnostic imaging , Brain*/physiopathology , Brain*/diagnostic imaging , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging, Humans ; Magnetic Resonance Imaging/methods ; Male ; Female ; Adult ; Neural Pathways/physiopathology ; Neural Pathways/diagnostic imaging ; Brain Mapping ; Middle Aged ; Young Adult ; Rest ; Generalized Anxiety Disorder

Characterization of a novel small chemical entity with anxiolytic- and antidepressant-like effects targeting multiple receptors.

Autori: Ogbu JI Moreira CVL Pereira JKA a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 15; Vol. 1007, pp. 178287. Date of Electronic Publication: 2025 Oct 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anti-Anxiety Agents*/pharmacology , Anti-Anxiety Agents*/chemistry , Anti-Anxiety Agents*/therapeutic use , Antidepressive Agents*/pharmacology , Antidepressive Agents*/chemistry , Antidepressive Agents*/therapeutic use , Acetamides*/pharmacology , Acetamides*/chemistry, Animals ; Mice ; Male ; Behavior, Animal/drug effects ; Humans ; Anxiety/drug therapy ; Anxiety/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal

Predicting generalized anxiety disorder among Chinese depressed adolescents: an explainable machine learning approach.

Autori: Geng S Wang J Xia Y a ďalší

Zdroj: BMC medical informatics and decision making [BMC Med Inform Decis Mak] 2025 Nov 03; Vol. 25 (1), pp. 406. Date of Electronic Publication: 2025 Nov 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101088682 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6947 (Electronic) Linking ISSN: 14726947 NLM ISO Abbreviation: BMC Med Inform Decis Mak Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anxiety Disorders*/diagnosis , Anxiety Disorders*/epidemiology , Machine Learning* , Depression*/epidemiology, Humans ; Adolescent ; Female ; Male ; China/epidemiology ; Risk Factors ; Generalized Anxiety Disorder ; East Asian People

Suicidal behavior, depression, generalized anxiety and associated factors among a national sample of adults in Mozambique in 2022 to 2023.

Autori: Pengpid S Peltzer K Efraime B Jr

Zdroj: The International journal of social psychiatry [Int J Soc Psychiatry] 2025 Nov; Vol. 71 (7), pp. 1361-1374. Date of Electronic Publication: 2025 May 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Sage Publications Country of Publication: England NLM ID: 0374726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1741-2854 (Electronic) Linking ISSN: 00207640 NLM ISO Abbreviation: Int J Soc Psychiatry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anxiety Disorders*/epidemiology , Anxiety Disorders*/psychology , Suicidal Ideation* , Depressive Disorder, Major*/epidemiology , Suicide, Attempted*/statistics & numerical data , Suicide, Attempted*/psychology, Humans ; Adult ; Female ; Mozambique/epidemiology ; Male ; Middle Aged ; Young Adult ; Prevalence ; Risk Factors ; Health Surveys ; Generalized Anxiety Disorder

Efficacy of a Smartphone-Based Digital Therapeutic (Anzeilax) in Generalized Anxiety Disorder: Randomized Controlled Trial.

Autori: Park C Song H Kim H a ďalší

Zdroj: Journal of medical Internet research [J Med Internet Res] 2025 Oct 14; Vol. 27, pp. e69981. Date of Electronic Publication: 2025 Oct 14.

Spôsob vydávania: Equivalence Trial; Journal Article; Randomized Controlled Trial

Informácie o časopise: Publisher: JMIR Publications Country of Publication: Canada NLM ID: 100959882 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-8871 (Electronic) Linking ISSN: 14388871 NLM ISO Abbreviation: J Med Internet Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Generalized Anxiety Disorder*/therapy , Smartphone*, Adult ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Anxiety Disorders/therapy ; Anxiety Disorders/drug therapy ; Treatment Outcome

Cerina-Cognitive Behavioral Therapy-Based Mobile App for Managing Generalized Anxiety Disorder Symptoms Among University Students: Results From a Pilot Feasibility Randomized Controlled Trial.

Autori: Eylem-van Bergeijk O Robinson T Manktelow M a ďalší

Zdroj: JMIR mHealth and uHealth [JMIR Mhealth Uhealth] 2025 Oct 09; Vol. 13, pp. e70691. Date of Electronic Publication: 2025 Oct 09.

Spôsob vydávania: Journal Article; Randomized Controlled Trial

Informácie o časopise: Publisher: JMIR Publications Inc Country of Publication: Canada NLM ID: 101624439 Publication Model: Electronic Cited Medium: Internet ISSN: 2291-5222 (Electronic) Linking ISSN: 22915222 NLM ISO Abbreviation: JMIR Mhealth Uhealth Subsets: MEDLINE

Výrazy zo slovníka MeSH: Students*/psychology , Students*/statistics & numerical data , Cognitive Behavioral Therapy*/methods , Cognitive Behavioral Therapy*/instrumentation , Cognitive Behavioral Therapy*/standards , Cognitive Behavioral Therapy*/statistics & numerical data , Mobile Applications*/standards , Mobile Applications*/statistics & numerical data , Anxiety Disorders*/therapy , Anxiety Disorders*/psychology, Humans ; Female ; Male ; Universities/organization & administration ; Universities/statistics & numerical data ; Pilot Projects ; Adult ; Surveys and Questionnaires ; Feasibility Studies ; Young Adult ; Generalized Anxiety Disorder

Altered Serum IL-6 and TGF-β1 Levels Are Associated With Generalized Anxiety Disorder: A Case-Control Study.

Autori: Alfi MA Naim J Ahmed I a ďalší

Zdroj: Developmental neurobiology [Dev Neurobiol] 2025 Oct; Vol. 85 (4), pp. e23004.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Subscription Services, Inc Country of Publication: United States NLM ID: 101300215 Publication Model: Print Cited Medium: Internet ISSN: 1932-846X (Electronic) Linking ISSN: 19328451 NLM ISO Abbreviation: Dev Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Interleukin-6*/blood , Transforming Growth Factor beta1*/blood , Anxiety Disorders*/blood , Anxiety Disorders*/diagnosis, Humans ; Male ; Female ; Adult ; Case-Control Studies ; Biomarkers/blood ; Young Adult ; Middle Aged ; Generalized Anxiety Disorder