Výsledky vyhledávání - "ALKALOIDS"

Integrated pharmacokinetic properties and tissue distribution of Corydalis saxicola Bunting total alkaloids in HFHCD-induced mice: Implications for pharmacokinetic variability in MASH treatment.

Autoři: Sun Q Chen H Lin Q a další

Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Nov; Vol. 192, pp. 118665. Date of Electronic Publication: 2025 Oct 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

Výrazy ze slovníku MeSH: Corydalis*/chemistry , Alkaloids*/pharmacokinetics , Alkaloids*/isolation & purification , Non-alcoholic Fatty Liver Disease*/drug therapy , Non-alcoholic Fatty Liver Disease*/metabolism, Animals ; Mice ; Male ; Tissue Distribution ; Diet, High-Fat/adverse effects ; Humans ; Liver/metabolism ; Liver/drug effects ; Berberine Alkaloids/pharmacokinetics ; Berberine/pharmacokinetics ; Berberine/analogs & derivatives ; Mice, Inbred C57BL ; Caco-2 Cells

An Innovative Use of the QuEChERs Method and LC-MS/MS Technique for Fast and Simple Determination of Quinolizidine Alkaloids in Leguminous Plants.

Autoři: Rutkowska E; Institute of Plant Protection-National Research Institute, Chełmońskiego 22 St, 15-195 Białystok, Poland.

Zdroj: Molecules (Basel, Switzerland) [Molecules] 2025 Oct 14; Vol. 30 (20). Date of Electronic Publication: 2025 Oct 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Výrazy ze slovníku MeSH: Tandem Mass Spectrometry*/methods , Alkaloids*/analysis , Alkaloids*/chemistry , Alkaloids*/isolation & purification , Quinolizidines*/analysis , Quinolizidines*/chemistry , Quinolizidines*/isolation & purification , Fabaceae*/chemistry, Chromatography, Liquid/methods ; Plant Extracts/chemistry ; Limit of Detection ; Quinolizidine Alkaloids ; Liquid Chromatography-Mass Spectrometry

In-depth characterization of quinolizidine alkaloids via highly efficient enrichment and multi-stage mass spectrometry.

Autoři: Zhang Z Yu W He X a další

Zdroj: Talanta [Talanta] 2025 Oct 01; Vol. 293, pp. 128141. Date of Electronic Publication: 2025 Apr 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

Výrazy ze slovníku MeSH: Alkaloids*/chemistry , Alkaloids*/analysis , Alkaloids*/isolation & purification , Sophora*/chemistry , Quinolizidines*/chemistry , Quinolizidines*/analysis , Quinolizidines*/isolation & purification, Mass Spectrometry/methods ; Quinolizidine Alkaloids

Copper-Mediated Homocoupling of N -propargylcytisine-Synthesis and Spectral Characterization of Novel Cytisine-Based Diyne Dimer.

Autoři: Przybył AK Huczyński A Krystkowiak E

Zdroj: Molecules (Basel, Switzerland) [Molecules] 2025 Oct 01; Vol. 30 (19). Date of Electronic Publication: 2025 Oct 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Výrazy ze slovníku MeSH: Azocines*/chemistry , Azocines*/chemical synthesis , Copper*/chemistry , Alkaloids*/chemistry , Alkaloids*/chemical synthesis , Quinolizines*/chemistry , Quinolizines*/chemical synthesis , Alkynes*/chemistry, Dimerization ; Molecular Structure ; Quinolizidine Alkaloids

Ancient gene clusters govern the initiation of monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion.

Autoři: Hwang J Kirshner J Deschênes DAR a další

Zdroj: Nature communications [Nat Commun] 2025 Nov 25; Vol. 16 (1), pp. 10495. Date of Electronic Publication: 2025 Nov 25.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Multigene Family* , Secologanin Tryptamine Alkaloids*/metabolism , Secologanin Tryptamine Alkaloids*/chemistry, Rauwolfia/genetics ; Rauwolfia/metabolism ; Rauwolfia/enzymology ; Catharanthus/genetics ; Catharanthus/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Stereoisomerism ; Phylogeny ; Oxidoreductases/metabolism ; Oxidoreductases/genetics ; Biosynthetic Pathways/genetics ; Evolution, Molecular ; Vinca Alkaloids

Investigation of N-(2-oxo-2H-chromen-3-carbonyl)cytisine's Molecular Structure in Solution.

Autoři: Kopbalina K Adekenova A Shaimerdenova Z a další

Zdroj: Molecules (Basel, Switzerland) [Molecules] 2025 Oct 20; Vol. 30 (20). Date of Electronic Publication: 2025 Oct 20.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Výrazy ze slovníku MeSH: Azocines*/chemistry , Quinolizines*/chemistry , Alkaloids*/chemistry , Coumarins*/chemistry, Molecular Structure ; Molecular Conformation ; Models, Molecular ; Magnetic Resonance Spectroscopy ; Solutions ; Quinolizidine Alkaloids

Regiospecific hydroxylase and O-methyltransferase for the biosynthesis of anticancer alkaloids in Tabernaemontana elegans (toad tree).

Autoři: Mann SGA Richardson MB Young RN a další

Zdroj: Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2025 Oct; Vol. 227, pp. 110161. Date of Electronic Publication: 2025 Jun 16.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: France NLM ID: 9882449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2690 (Electronic) Linking ISSN: 09819428 NLM ISO Abbreviation: Plant Physiol Biochem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Tabernaemontana*/enzymology , Tabernaemontana*/metabolism , Tabernaemontana*/genetics , Methyltransferases*/metabolism , Methyltransferases*/genetics , Mixed Function Oxygenases*/metabolism , Mixed Function Oxygenases*/genetics , Alkaloids*/biosynthesis , Plant Proteins*/metabolism , Plant Proteins*/genetics, Secologanin Tryptamine Alkaloids/metabolism

Identification of the anti-epileptic effect of speciogynine through molecular network-aided metabolite profiling of M. speciosa alkaloids using zebrafish.

Autoři: Garba SA Swain P Shaari K a další

Zdroj: Fitoterapia [Fitoterapia] 2025 Jul; Vol. 184, pp. 106667. Date of Electronic Publication: 2025 Jun 09.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

Výrazy ze slovníku MeSH: Mitragyna*/chemistry , Anticonvulsants*/pharmacology , Anticonvulsants*/isolation & purification , Anticonvulsants*/chemistry , Secologanin Tryptamine Alkaloids*/pharmacology , Secologanin Tryptamine Alkaloids*/isolation & purification , Secologanin Tryptamine Alkaloids*/chemistry , Indole Alkaloids*/pharmacology , Indole Alkaloids*/isolation & purification , Indole Alkaloids*/chemistry, Animals ; Zebrafish ; Plant Leaves/chemistry ; Molecular Structure ; Tandem Mass Spectrometry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Phytochemicals/pharmacology ; Phytochemicals/isolation & purification ; Plant Bark/chemistry ; Fruit/chemistry ; Alkaloids/pharmacology ; Plant Stems/chemistry

Probabilistic exposure assessment and risk characterization of quinolizidine alkaloids and phomopsin A in the Belgian population.

Autoři: Schryvers S Miserez B Eeckhout M a další

Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2026 Jan; Vol. 207, pp. 115812. Date of Electronic Publication: 2025 Oct 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Alkaloids*/analysis , Alkaloids*/toxicity , Quinolizidines*/analysis , Quinolizidines*/toxicity , Lupinus*/chemistry , Food Contamination*/analysis , Dietary Exposure*/analysis, Humans ; Belgium ; Risk Assessment ; Adult ; Female ; Male ; Middle Aged ; Young Adult ; Monte Carlo Method ; Adolescent ; Surveys and Questionnaires ; Aged ; Quinolizidine Alkaloids

Cytotoxic lycorine alkaloids of the plant family Amaryllidaceae.

Autoři: Nair JJ van Staden J

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Aug; Vol. 163, pp. 108619. Date of Electronic Publication: 2025 May 23.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Amaryllidaceae*/chemistry , Amaryllidaceae Alkaloids*/pharmacology , Amaryllidaceae Alkaloids*/chemistry , Amaryllidaceae Alkaloids*/isolation & purification , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/isolation & purification , Phenanthridines*/chemistry , Phenanthridines*/pharmacology , Phenanthridines*/isolation & purification, Animals ; Humans ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Molecular Structure ; Structure-Activity Relationship ; Caspase 3/chemistry ; Caspase 3/metabolism ; Alkaloids/chemistry ; Alkaloids/metabolism ; Alkaloids/pharmacology

Evaluation of iso -quinoline alkaloids by RP-HPLC-PDA in different Berberis species collected from Western Himalayan Region.

Autoři: Chaudhary MK Kumar B Agnihotri P a další

Zdroj: Natural product research [Nat Prod Res] 2025 Jul; Vol. 39 (13), pp. 3760-3765. Date of Electronic Publication: 2024 Feb 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Berberis*/chemistry , Alkaloids*/chemistry , Alkaloids*/analysis , Quinolines*/chemistry , Quinolines*/analysis, Chromatography, High Pressure Liquid/methods ; India ; Berberine/analogs & derivatives ; Berberine/analysis ; Berberine/chemistry ; Berberine Alkaloids/analysis ; Berberine Alkaloids/chemistry

Identification of a new QTL associated to reduced quinolizidine alkaloid content in white lupin (Lupinus albus, L.) and development of ultra-low alkaloid recombinants by stacking with the pauper allele.

Autoři: Patyi A Kamp M Arncken C a další

Zdroj: BMC plant biology [BMC Plant Biol] 2025 Jul 22; Vol. 25 (1), pp. 945. Date of Electronic Publication: 2025 Jul 22.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 100967807 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2229 (Electronic) Linking ISSN: 14712229 NLM ISO Abbreviation: BMC Plant Biol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Lupinus*/genetics , Lupinus*/metabolism , Lupinus*/chemistry , Quantitative Trait Loci*/genetics , Alkaloids*/metabolism , Quinolizidines*/metabolism, Alleles ; Chromosome Mapping ; Quinolizidine Alkaloids

Transcriptomics and network pharmacology analysis reveal key genes in alkaloid biosynthesis in Zephyranthes candida and therapeutic targets for LIHC.

Autoři: Xie W Sun M Fan J a další

Zdroj: Planta [Planta] 2025 Jul 10; Vol. 262 (2), pp. 45. Date of Electronic Publication: 2025 Jul 10.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer-Verlag [etc.] Country of Publication: Germany NLM ID: 1250576 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-2048 (Electronic) Linking ISSN: 00320935 NLM ISO Abbreviation: Planta Subsets: MEDLINE

Výrazy ze slovníku MeSH: Amaryllidaceae Alkaloids*/therapeutic use , Amaryllidaceae Alkaloids*/metabolism , Liver Neoplasms*/drug therapy , Carcinoma, Hepatocellular*/drug therapy , Transcriptome*/genetics , Amaryllidaceae*/genetics , Amaryllidaceae*/metabolism, Molecular Docking Simulation ; Network Pharmacology ; Phenanthridines/metabolism ; Phenanthridines/therapeutic use ; Phenanthridines/pharmacology ; Gene Expression Profiling ; Phylogeny ; Humans ; Alkaloids/biosynthesis ; Gene Expression Regulation, Plant

Method for determination of cytisine in post-mortem biological matrices and its application to two forensic cases.

Autoři: Nowak K Szpot P Zawadzki M a další

Zdroj: Forensic toxicology [Forensic Toxicol] 2025 Jul; Vol. 43 (2), pp. 385-394. Date of Electronic Publication: 2024 Dec 19.

Způsob vydávání: Journal Article; Case Reports

Informace o časopise: Publisher: Japanese Association of Forensic Toxicology Country of Publication: Japan NLM ID: 101315563 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1860-8965 (Print) Linking ISSN: 18608965 NLM ISO Abbreviation: Forensic Toxicol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Azocines*/analysis , Azocines*/poisoning , Alkaloids*/analysis , Alkaloids*/poisoning , Quinolizines*/analysis , Quinolizines*/poisoning, Humans ; Male ; Tandem Mass Spectrometry ; Chromatography, High Pressure Liquid ; Forensic Toxicology/methods ; Bile/chemistry ; Vitreous Body/chemistry ; Smoking Cessation ; Liquid-Liquid Extraction ; Middle Aged ; Adult ; Quinolizidine Alkaloids

Discovery of corynanthe synthases in Camptotheca acuminata: medium-chain dehydrogenase/reductase-based gateway to corynanthe-type compound diversification.

Autoři: Bui VH Nguyen TM Kim T a další

Zdroj: Planta [Planta] 2025 Aug 13; Vol. 262 (4), pp. 80. Date of Electronic Publication: 2025 Aug 13.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer-Verlag [etc.] Country of Publication: Germany NLM ID: 1250576 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-2048 (Electronic) Linking ISSN: 00320935 NLM ISO Abbreviation: Planta Subsets: MEDLINE

Výrazy ze slovníku MeSH: Camptotheca*/enzymology , Camptotheca*/genetics , Camptotheca*/metabolism , Oxidoreductases*/metabolism , Oxidoreductases*/genetics , Plant Proteins*/metabolism , Plant Proteins*/genetics , Indole Alkaloids*/metabolism, Phylogeny ; Secologanin Tryptamine Alkaloids/metabolism ; Computational Biology ; Models, Molecular

Studies Related to the Proposed Biotransformation of Bohemamine D into the Co-occurring Marine Natural Product Spinoxazine B.

Autoři: Yi L Guo C Yan Q a další

Zdroj: Journal of natural products [J Nat Prod] 2025 Apr 25; Vol. 88 (4), pp. 1004-1011. Date of Electronic Publication: 2025 Mar 31.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

Výrazy ze slovníku MeSH: Biological Products*/chemistry , Biological Products*/metabolism , Oxazines*/chemistry , Oxazines*/metabolism , Pyrrolizidine Alkaloids*/chemistry , Pyrrolizidine Alkaloids*/metabolism , Streptomyces*/chemistry , Streptomyces*/metabolism, Biotransformation ; Molecular Structure ; Alkaloids/chemistry ; Alkaloids/metabolism

Berberine and Palmatine Distribution Across Plant Organs in Berberis darwinii : Basis for Selecting Superior-Producing Accessions.

Autoři: Chacón-Fuentes M Burgos-Díaz C Opazo-Navarrete M a další

Zdroj: Molecules (Basel, Switzerland) [Molecules] 2025 Apr 20; Vol. 30 (8). Date of Electronic Publication: 2025 Apr 20.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Výrazy ze slovníku MeSH: Berberis*/chemistry , Berberis*/metabolism , Berberine*/metabolism , Berberine*/chemistry , Berberine*/analysis , Berberine Alkaloids*/metabolism , Berberine Alkaloids*/chemistry , Berberine Alkaloids*/analysis, Plant Leaves/chemistry ; Plant Leaves/metabolism ; Plant Roots/chemistry ; Chromatography, High Pressure Liquid ; Plant Extracts/chemistry ; Fruit/chemistry ; Alkaloids ; Plant Stems/chemistry

Molecular Networks as Strategy for Dereplication of Steroidal Alkaloids of Herbarium Samples of Solanum jabrense Agra and M. Nee, an Endemic and Unexplored Species.

Autoři: Lima E Silva A de Medeiros Brito TA Agra MF a další

Zdroj: Chemistry & biodiversity [Chem Biodivers] 2025 Jun; Vol. 22 (6), pp. e202402513. Date of Electronic Publication: 2024 Dec 14.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Výrazy ze slovníku MeSH: Solanum*/chemistry , Solanum*/metabolism , Alkaloids*/chemistry , Alkaloids*/isolation & purification , Alkaloids*/analysis , Steroids*/chemistry , Steroids*/isolation & purification, Tandem Mass Spectrometry ; Chromatography, Liquid ; Plant Extracts/chemistry ; Solanaceous Alkaloids/chemistry ; Molecular Structure

CaMKK as a Potential Target for the Natural Product Insecticide Cytisine against Megoura japonica Matsumura.

Autoři: Liu C Zhang X Zhang Q a další

Zdroj: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 May 21; Vol. 73 (20), pp. 12261-12271. Date of Electronic Publication: 2025 May 07.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Azocines*/pharmacology , Azocines*/chemistry , Insecticides*/chemistry , Insecticides*/pharmacology , Alkaloids*/pharmacology , Alkaloids*/chemistry , Quinolizines*/pharmacology , Quinolizines*/chemistry , Insect Proteins*/genetics , Insect Proteins*/chemistry , Insect Proteins*/metabolism , Insect Proteins*/antagonists & inhibitors , Aphids*/drug effects , Aphids*/genetics , Aphids*/enzymology , Aphids*/chemistry , Aphids*/metabolism , Biological Products*/pharmacology , Biological Products*/chemistry, Molecular Docking Simulation ; Animals ; Quinolizidine Alkaloids

Molecular Mechanisms of Reversal of Multidrug Resistance in Breast Cancer by Inhibition of P-gp by Cytisine N-Isoflavones Derivatives Explored Through Network Pharmacology, Molecular Docking, and Molecular Dynamics.

Autoři: Xiao C Yin X Xi R a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Apr 17; Vol. 26 (8). Date of Electronic Publication: 2025 Apr 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drug Resistance, Neoplasm*/drug effects , Azocines*/pharmacology , Azocines*/chemistry , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Drug Resistance, Multiple*/drug effects , Quinolizines*/pharmacology , Quinolizines*/chemistry , Isoflavones*/pharmacology , Isoflavones*/chemistry , Alkaloids*/pharmacology , Alkaloids*/chemistry , ATP Binding Cassette Transporter, Subfamily B, Member 1*/antagonists & inhibitors , ATP Binding Cassette Transporter, Subfamily B, Member 1*/metabolism , ATP Binding Cassette Transporter, Subfamily B, Member 1*/chemistry, Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Female ; Network Pharmacology ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Quinolizidine Alkaloids