Suchergebnisse - "6]"

Vitamin B-6 Deficiency Induces Anxiety-Like Behavior in Sprague-Dawley Rats by Disrupting Gut Homeostasis.

Autoren: Amarasena S Hossain KS Rasouli A et al.

Quelle: The Journal of nutrition [J Nutr] 2025 Oct; Vol. 155 (10), pp. 3254-3266. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE

MeSH-Schlagworte: Gastrointestinal Microbiome* , Anxiety*/etiology , Homeostasis* , Vitamin B 6 Deficiency*/complications, Animals ; Rats, Sprague-Dawley ; Rats ; Male ; Vitamin B 6/blood ; Behavior, Animal

Embelin improves alcoholic steatohepatitis in alcohol-associated liver disease via ATF6-mediated P2X7r-NLRP3 signaling pathway.

Autoren: Zhang JJ Zhong JT Wang WL et al.

Quelle: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 May; Vol. 140, pp. 156638. Date of Electronic Publication: 2025 Mar 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH-Schlagworte: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Fatty Liver, Alcoholic*/drug therapy , Fatty Liver, Alcoholic*/metabolism , Activating Transcription Factor 6*/metabolism , Activating Transcription Factor 6*/genetics , Receptors, Purinergic P2X7*/metabolism , Benzoquinones*/pharmacology, Animals ; Signal Transduction/drug effects ; Mice ; Humans ; Male ; Hep G2 Cells ; Mice, Inbred C57BL ; Disease Models, Animal ; Liver/drug effects ; Liver/metabolism ; Macrophages/drug effects ; TNF Receptor-Associated Factor 6

Therapeutic Impact of Gardasil ^® in Recurrent Respiratory Papillomatosis: A Retrospective Study on RRP Patients.

Autoren: Sieg J Fazel A Quabius ES et al.

Quelle: Viruses [Viruses] 2025 Feb 26; Vol. 17 (3). Date of Electronic Publication: 2025 Feb 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH-Schlagworte: Papillomavirus Infections*/prevention & control , Papillomavirus Infections*/surgery , Papillomavirus Infections*/virology , Papillomavirus Infections*/drug therapy , Respiratory Tract Infections*/prevention & control , Respiratory Tract Infections*/surgery , Respiratory Tract Infections*/virology , Respiratory Tract Infections*/drug therapy , Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18*/therapeutic use , Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18*/administration & dosage , Papillomavirus Vaccines*, Humans ; Retrospective Studies ; Female ; Male ; Adult ; Adolescent ; Middle Aged ; Child ; Young Adult ; Vaccination ; Human papillomavirus 11/immunology ; Human papillomavirus 6/immunology

SCR Disease Name: Recurrent respiratory papillomatosis

Impact of Regulatory Action on Dose Maximalization for Vitamin B6 Dietary Supplements on the Reporting Pattern for Neuropathy.

Autoren: van Hunsel F Scholl J Vrolijk M et al.

Quelle: Pharmacoepidemiology and drug safety [Pharmacoepidemiol Drug Saf] 2025 Feb; Vol. 34 (2), pp. e70108.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 9208369 Publication Model: Print Cited Medium: Internet ISSN: 1099-1557 (Electronic) Linking ISSN: 10538569 NLM ISO Abbreviation: Pharmacoepidemiol Drug Saf Subsets: MEDLINE

MeSH-Schlagworte: Vitamin B 6*/administration & dosage , Vitamin B 6*/adverse effects , Vitamin B 6*/blood , Dietary Supplements*/adverse effects , Adverse Drug Reaction Reporting Systems*/statistics & numerical data , Peripheral Nervous System Diseases*/chemically induced , Peripheral Nervous System Diseases*/epidemiology , Nervous System Diseases*/chemically induced , Nervous System Diseases*/epidemiology, Humans ; Netherlands/epidemiology ; Dose-Response Relationship, Drug ; Male ; Female ; Middle Aged ; Aged ; Adult ; Vitamin B 6 Deficiency/drug therapy

Contribution of vitamin B 6 deficiency to anemia in children on regular hemodialysis.

Autoren: Atia F Bazaraa H Abdelatty Y et al.

Quelle: BMC pediatrics [BMC Pediatr] 2025 Jan 27; Vol. 25 (1), pp. 64. Date of Electronic Publication: 2025 Jan 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100967804 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2431 (Electronic) Linking ISSN: 14712431 NLM ISO Abbreviation: BMC Pediatr Subsets: MEDLINE

MeSH-Schlagworte: Renal Dialysis* , Anemia*/etiology , Anemia*/blood , Vitamin B 6 Deficiency*/complications , Vitamin B 6 Deficiency*/blood , Kidney Failure, Chronic*/therapy , Kidney Failure, Chronic*/complications , Kidney Failure, Chronic*/blood, Humans ; Male ; Cross-Sectional Studies ; Female ; Child ; Hemoglobins/analysis ; Hemoglobins/metabolism ; Adolescent ; Case-Control Studies ; Child, Preschool ; Vitamin B 6/blood ; Erythropoietin/therapeutic use

Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation.

Autoren: Vojdani A Almulla AF Vojdani E et al.

Quelle: Journal of advanced research [J Adv Res] 2025 Dec; Vol. 78, pp. 543-553. Date of Electronic Publication: 2025 Feb 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE

MeSH-Schlagworte: Multiple Sclerosis, Relapsing-Remitting*/immunology , Multiple Sclerosis, Relapsing-Remitting*/diagnosis , Multiple Sclerosis, Relapsing-Remitting*/virology , Herpesvirus 6, Human*/immunology , Herpesvirus 6, Human*/physiology , Herpesvirus 4, Human*/immunology , Herpesvirus 4, Human*/physiology , Myelin Proteins*/immunology , Autoimmunity*/immunology, Humans ; Female ; Adult ; Male ; Biomarkers/blood ; Middle Aged ; Immunoglobulin G/immunology ; Immunoglobulin G/blood ; Prognosis ; Immunoglobulin M/immunology ; Immunoglobulin M/blood ; Young Adult ; Autoantibodies/immunology ; Autoantibodies/blood ; Case-Control Studies ; Immunoglobulin A/immunology ; Disease Progression

Dual targeting of Phosphoinositide 3-Kinase (PI3K) and histone deacetylase 6 (HDAC6) in cancer.

Autoren: Hamdoun S Ahemad N Syed Mohamad SA

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117361. Date of Electronic Publication: 2025 Sep 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/drug therapy , Neoplasms*/enzymology , Neoplasms*/metabolism , Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/administration & dosage , Histone Deacetylase Inhibitors*/therapeutic use , Histone Deacetylase Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Phosphoinositide-3 Kinase Inhibitors* , Phosphatidylinositol 3-Kinases*/metabolism, Humans ; Animals

NEAT1 inhibits granulosa cell apoptosis and promotes cell growth and migration through the miR-130a-3p/BMP6 axis.

Autoren: Chen W Dong L Liang Q et al.

Quelle: Reproductive biomedicine online [Reprod Biomed Online] 2025 Dec; Vol. 51 (6), pp. 104870. Date of Electronic Publication: 2025 Feb 19.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE

MeSH-Schlagworte: Apoptosis*/genetics , Bone Morphogenetic Protein 6*/metabolism , Bone Morphogenetic Protein 6*/genetics , Cell Movement* , Granulosa Cells*/metabolism , Granulosa Cells*/physiology , MicroRNAs*/metabolism , MicroRNAs*/genetics , RNA, Long Noncoding*/metabolism , RNA, Long Noncoding*/genetics, Adult ; Female ; Humans ; Cell Proliferation ; Ovarian Reserve ; Clinical Trials as Topic

Design, synthesis and pharmacological evaluation of multitarget GPR40 agonists/HDAC6 inhibitors for Alzheimer's disease.

Autoren: Pinheiro PSM de Chirico F Loi M et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 15; Vol. 296, pp. 117868. Date of Electronic Publication: 2025 Jun 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Drug Design* , Receptors, G-Protein-Coupled*/agonists , Receptors, G-Protein-Coupled*/metabolism , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemical synthesis , Neuroprotective Agents*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Line, Tumor

Design, synthesis, and biological evaluation of indazole-based histone deacetylase 6 inhibitors.

Autoren: Ali KH Gupta SK Oh YJ et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 05; Vol. 295, pp. 117785. Date of Electronic Publication: 2025 May 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Drug Design* , Indazoles*/chemistry , Indazoles*/pharmacology , Indazoles*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry, Humans ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HCT116 Cells ; Animals ; Rats

Human Herpesvirus 6-Associated Unilateral Panuveitis Mimicking Endogenous Endophthalmitis in a Case with Ulcerative Colitis: Report of a Case and Literature Review.

Autoren: Karti O Ayhan Z Lebe B et al.

Quelle: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2025 Oct; Vol. 33 (8), pp. 1859-1864. Date of Electronic Publication: 2025 Jun 06.

Publikationsart: Case Reports; Journal Article; Review

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9312169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-5078 (Electronic) Linking ISSN: 09273948 NLM ISO Abbreviation: Ocul Immunol Inflamm Subsets: MEDLINE

MeSH-Schlagworte: Colitis, Ulcerative*/complications , Colitis, Ulcerative*/diagnosis , Endophthalmitis*/diagnosis , Panuveitis*/diagnosis , Panuveitis*/virology , Panuveitis*/drug therapy , Eye Infections, Viral*/diagnosis , Eye Infections, Viral*/virology , Eye Infections, Viral*/drug therapy , Herpesvirus 6, Human*/genetics , Herpesvirus 6, Human*/isolation & purification , Roseolovirus Infections*/diagnosis , Roseolovirus Infections*/virology , Roseolovirus Infections*/drug therapy, Humans ; Female ; Adult ; Diagnosis, Differential ; DNA, Viral/analysis ; Vitrectomy ; Polymerase Chain Reaction ; Slit Lamp Microscopy

Design, synthesis and biological evaluation of novel histone deacetylase 6 inhibitors containing indole-based cap groups.

Autoren: Zhang X Nie H Zhao J et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130399. Date of Electronic Publication: 2025 Sep 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Drug Design* , Indoles*/chemistry , Indoles*/pharmacology , Indoles*/chemical synthesis , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Structure-Activity Relationship ; Humans ; Molecular Structure ; Cell Proliferation/drug effects ; Molecular Docking Simulation ; Apoptosis/drug effects ; Drug Screening Assays, Antitumor ; Animals ; Dose-Response Relationship, Drug ; Cell Line, Tumor

Design, synthesis, and biological evaluation of quinazolin-4-one-based selective HDAC6 inhibitors targeting serine 531, histidine 614 residues, and the L1 and L2 loop.

Autoren: Gupta SK Oh YJ Kim M et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118184. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Drug Design* , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemistry , Quinazolinones*/chemical synthesis, Humans ; Cell Proliferation/drug effects ; Animals ; Structure-Activity Relationship ; Mice ; Molecular Structure ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Dose-Response Relationship, Drug ; Apoptosis/drug effects ; Microsomes, Liver/metabolism

HDAC6 inhibition attenuates RIPK1/RIPK3/MLKL signalling and improves anti-tumor immune response in oral cancer.

Autoren: Mahale A Regula S Chanchlani B et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115634. Date of Electronic Publication: 2025 Oct 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/immunology , Mouth Neoplasms*/pathology , Hydroxamic Acids*/pharmacology , Hydroxamic Acids*/therapeutic use , Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/therapeutic use , Indoles*/pharmacology , Indoles*/therapeutic use , Squamous Cell Carcinoma of Head and Neck*/drug therapy , Squamous Cell Carcinoma of Head and Neck*/immunology, Animals ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Signal Transduction/drug effects ; Cell Line, Tumor ; Mice ; Humans ; Protein Kinases/metabolism ; Tumor Microenvironment/drug effects ; Mice, Inbred C57BL ; Female ; Male

Long term immunogenicity of two doses of the quadrivalent HPV vaccine and the effect of an additional dose given five years post-primary vaccination.

Autoren: Sauvageau C Ionescu IG Ouakki M et al.

Quelle: Vaccine [Vaccine] 2025 Dec 05; Vol. 68, pp. 127893. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Viral*/blood , Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18*/immunology , Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18*/administration & dosage , Papillomavirus Infections*/prevention & control , Papillomavirus Infections*/immunology , Immunogenicity, Vaccine* , Papillomavirus Vaccines*/administration & dosage , Papillomavirus Vaccines*/immunology, Humans ; Female ; Child ; Immunization Schedule ; Vaccination ; Immunization, Secondary

APIP regulates the priming of canonical NLRP3 and non-canonical Caspase-11/4 inflammasomes by binding to TRAF6.

Autoren: Jung K Kawamura M Lim B et al.

Quelle: Nature communications [Nat Commun] 2025 Dec 03; Vol. 16 (1), pp. 10866. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Inflammasomes*/metabolism , Inflammasomes*/immunology , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , Caspases, Initiator*/metabolism , TNF Receptor-Associated Factor 6*/metabolism , TNF Receptor-Associated Factor 6*/genetics , Caspases*/metabolism, Animals ; Humans ; Mice ; Macrophages/metabolism ; Macrophages/immunology ; Mice, Knockout ; Mice, Transgenic ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Inflammation/metabolism ; Lipopolysaccharides ; Signal Transduction ; Pyroptosis ; Protein Binding

HNRNPA1 promotes TRIM37 mRNA stability and mediates TRAF6 ubiquitination to alleviate osteoarthritis.

Autoren: Deng H Liu W Xiang L et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115568. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Osteoarthritis*/metabolism , Osteoarthritis*/pathology , Osteoarthritis*/genetics , Chondrocytes*/metabolism , Tripartite Motif Proteins*/genetics , Tripartite Motif Proteins*/metabolism , TNF Receptor-Associated Factor 6*/metabolism , TNF Receptor-Associated Factor 6*/genetics , Heterogeneous Nuclear Ribonucleoprotein A1*/metabolism , Heterogeneous Nuclear Ribonucleoprotein A1*/genetics , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics, Animals ; Ubiquitination ; Mice ; RNA Stability ; Humans ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; Disease Models, Animal ; Male ; Autophagy ; Pyroptosis

Targeting MCM6 Enhances Melphalan Chemosensitivity in Retinoblastoma by Modulating DNA Damage Response.

Autoren: Wang M Tang J Li J et al.

Quelle: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Dec 01; Vol. 66 (15), pp. 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

MeSH-Schlagworte: Retinoblastoma*/drug therapy , Retinoblastoma*/genetics , Retinoblastoma*/metabolism , Retinoblastoma*/pathology , Melphalan*/pharmacology , Melphalan*/therapeutic use , Antineoplastic Agents, Alkylating*/pharmacology , Antineoplastic Agents, Alkylating*/therapeutic use , Retinal Neoplasms*/drug therapy , Retinal Neoplasms*/genetics , Retinal Neoplasms*/metabolism , Retinal Neoplasms*/pathology , DNA Damage* , Minichromosome Maintenance Complex Component 6*/genetics , Minichromosome Maintenance Complex Component 6*/biosynthesis , Minichromosome Maintenance Complex Component 6*/metabolism , Gene Expression Regulation, Neoplastic*, Humans ; Animals ; Mice ; Cell Proliferation ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Gene Knockdown Techniques ; Cell Cycle ; Drug Resistance, Neoplasm

A-to-I RNA Edited miR-605-3p Has a Heightened Anti-Tumor Effect in Colorectal Cancer Through Modulating Immune Infiltration Mediated by CDK6.

Autoren: Cai XZ Li DY Gou K et al.

Quelle: The journal of gene medicine [J Gene Med] 2025 Dec; Vol. 27 (12), pp. e70060.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 9815764 Publication Model: Print Cited Medium: Internet ISSN: 1521-2254 (Electronic) Linking ISSN: 1099498X NLM ISO Abbreviation: J Gene Med Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/mortality , MicroRNAs*/genetics , Cyclin-Dependent Kinase 6*/genetics , Cyclin-Dependent Kinase 6*/metabolism , RNA Editing* , Adenosine*/genetics, Humans ; Animals ; Cell Proliferation/genetics ; Mice ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Apoptosis/genetics ; Female ; Male ; Inosine/genetics ; CD8-Positive T-Lymphocytes/immunology ; Prognosis ; Middle Aged

Human papillomavirus (HPV) type 16 and type 18 antibody concentrations after a single dose of bivalent HPV vaccine in girls aged 9-14 years compared with three doses of quadrivalent HPV vaccine in women aged 18-25 years in Costa Rica (PRIMAVERA): a non-randomised, open-label, immunobridging, non-inferiority trial.

Autoren: Cortés B Ocampo R Porras C et al.

Quelle: The Lancet. Infectious diseases [Lancet Infect Dis] 2025 Dec; Vol. 25 (12), pp. 1314-1324. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Clinical Trial, Phase III; Comparative Study; Equivalence Trial; Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Viral*/blood , Human papillomavirus 16*/immunology , Human papillomavirus 18*/immunology , Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18*/administration & dosage , Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18*/immunology , Papillomavirus Infections*/prevention & control , Papillomavirus Infections*/immunology , Papillomavirus Vaccines*/administration & dosage , Papillomavirus Vaccines*/immunology, Adolescent ; Adult ; Child ; Female ; Humans ; Young Adult ; Costa Rica/epidemiology ; Human Papillomavirus Viruses ; Immunization Schedule ; Vaccination