Výsledky vyhľadávania - "5.1 Pharmaceuticals (hrcs-rac)"

Repurposing clonixin and flunixin as anti-fibrotic candidates: Computational and preclinical evaluation in bleomycin-induced pulmonary fibrosis in rats

Autori: Gawli, Chandrakant Gavhane, Swapnil Das, Biswajit a ďalší

Zdroj: Research in Veterinary Science. 197

Predmety: 3009 Veterinary Sciences (for-2020), 30 Agricultural, Veterinary and Food Sciences (for-2020), Autoimmune Disease (rcdc), Lung (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Respiratory (hrcs-hc), Clonixin, Flunixin, Repurposing, Pulmonary anti-fibrotic therapy, Molecular docking simulation, Veterinary drug repurposing, Clonixin, Flunixin, Molecular docking simulation, Pulmonary anti-fibrotic therapy, Repurposing, Veterinary drug repurposing, 0702 Animal Production (for), 0707 Veterinary Sciences (for), Veterinary Sciences (science-metrix), 3003 Animal production (for-2020), 3009 Veterinary sciences (for-2020)

Prístupová URL adresa: https://escholarship.org/uc/item/0zf0t535

Multifunctional and Scalable Nanoparticles for Bimodal Image-Guided Phototherapy in Bladder Cancer Treatment

Autori: Tang, Menghuan Mahri, Sohaib Shiau, Ya-Ping a ďalší

Zdroj: Nano-Micro Letters. 17(1)

Predmety: 3403 Macromolecular and Materials Chemistry (for-2020), 34 Chemical Sciences (for-2020), 40 Engineering (for-2020), 4016 Materials Engineering (for-2020), 4018 Nanotechnology (for-2020), Biomedical Imaging (rcdc), Nanotechnology (rcdc), Urologic Diseases (rcdc), Biotechnology (rcdc), Cancer (rcdc), Bioengineering (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Image-guided phototherapy, Photodynamic and photothermal therapy, Bladder cancer treatment, Photoacoustic imaging, Microfluidics-aided production, Bladder cancer treatment, Image-guided phototherapy, Microfluidics-aided production, Photoacoustic imaging, Photodynamic and photothermal therapy, 3403 Macromolecular and materials chemistry (for-2020), 4016 Materials engineering (for-2020), 4018 Nanotechnology (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/6n8826fm
https://escholarship.org/content/qt6n8826fm/qt6n8826fm.pdf

Oxidative stress-regulatory role of miR-10b-5p in the diabetic human cornea revealed through integrated multi-omics analysis

Autori: Zha, Daxian Gamez, Joshua Ebrahimi, Shaghaiegh M a ďalší

Zdroj: Diabetologia

Predmety: 32 Biomedical and Clinical Sciences (for-2020), 3212 Ophthalmology and Optometry (for-2020), Biotechnology (rcdc), Genetics (rcdc), Diabetes (rcdc), Eye Disease and Disorders of Vision (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 5.1 Pharmaceuticals (hrcs-rac), Eye (hrcs-hc), Corneal limbal stem cells, Diabetic cornea, GCLM, Glutamate-cysteine ligase (GCL), Glutathione (GSH), LANCL1, miR-10b-5p, miRNA, Oxidative stress, Proteomics, Transcriptomics, GCLM, LANCL1, Corneal limbal stem cells, Diabetic cornea, Glutamate-cysteine ligase (GCL), Glutathione (GSH), Oxidative stress, Proteomics, Transcriptomics, miR-10b-5p, miRNA, 1103 Clinical Sciences (for), 1114 Paediatrics and Reproductive Medicine (for), 1117 Public Health and Health Services (for), Endocrinology & Metabolism (science-metrix), 3202 Clinical sciences (for-2020), 4206 Public health (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/3589q7ft
https://escholarship.org/content/qt3589q7ft/qt3589q7ft.pdf

ATPase copper transporting beta contributes to cisplatin resistance as a regulatory factor of extracellular vesicles in head and neck squamous cell carcinoma

Autori: Ogawa, Tatsuo Ono, Kisho Ryumon, Shoji a ďalší

Zdroj: Cancer Gene Therapy

Predmety: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Dental/Oral and Craniofacial Disease (rcdc), Cancer (rcdc), Rare Diseases (rcdc), Orphan Drug (rcdc), Genetics (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), 1112 Oncology and Carcinogenesis (for), Oncology & Carcinogenesis (science-metrix), 3211 Oncology and carcinogenesis (for-2020)

Prístupová URL adresa: https://escholarship.org/uc/item/44t579gj

A Comparison of AI and Population PK Models to Predict the Concentrations of Antiepileptic Drugs Using Therapeutic Drug Monitoring Records

Autori: Chung, Tae Kyu Lee, Howard

Zdroj: Clinical and Translational Science. 18(10)

Predmety: 3214 Pharmacology and Pharmaceutical Sciences (for-2020), 32 Biomedical and Clinical Sciences (for-2020), Rare Diseases (rcdc), Networking and Information Technology R&D (NITRD) (rcdc), Orphan Drug (rcdc), Machine Learning and Artificial Intelligence (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Generic health relevance (hrcs-hc), Humans (mesh), Anticonvulsants (mesh), Drug Monitoring (mesh), Models, Biological (mesh), Artificial Intelligence (mesh), Prohibitins (mesh), Male (mesh), Epilepsy (mesh), Female (mesh), Adult (mesh), Middle Aged (mesh), Valproic Acid (mesh), Phenytoin (mesh), Phenobarbital (mesh), Carbamazepine (mesh), Young Adult (mesh), artificial intelligence, population pharmacokinetic model, predictive performance, Humans (mesh), Epilepsy (mesh), Valproic Acid (mesh), Phenytoin (mesh), Phenobarbital (mesh), Carbamazepine (mesh), Anticonvulsants (mesh), Drug Monitoring (mesh), Models, Biological (mesh), Artificial Intelligence (mesh), Adult (mesh), Middle Aged (mesh), Female (mesh), Male (mesh), Young Adult (mesh), Prohibitins (mesh), artificial intelligence, population pharmacokinetic model, predictive performance, Humans (mesh), Anticonvulsants (mesh), Drug Monitoring (mesh), Models, Biological (mesh), Artificial Intelligence (mesh), Prohibitins (mesh), Male (mesh), Epilepsy (mesh), Female (mesh), Adult (mesh), Middle Aged (mesh), Valproic Acid (mesh), Phenytoin (mesh), Phenobarbital (mesh), Carbamazepine (mesh), Young Adult (mesh), 1102 Cardiorespiratory Medicine and Haematology (for), 1112 Oncology and Carcinogenesis (for), 1199 Other Medical and Health Sciences (for), General Clinical Medicine (science-metrix), 3201 Cardiovascular medicine and haematology (for-2020), 3214 Pharmacology and pharmaceutical sciences (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/9qj6q3pt
https://escholarship.org/content/qt9qj6q3pt/qt9qj6q3pt.pdf

Repurposing flavopiridol as an inhaled therapeutic for pulmonary fibrosis

Autori: Chen, Ching-Hsien Chaudhary, Subash K Chang, Wen-Hsin a ďalší

Zdroj: European Journal of Pharmacology. 1005

Predmety: 3214 Pharmacology and Pharmaceutical Sciences (for-2020), 32 Biomedical and Clinical Sciences (for-2020), Autoimmune Disease (rcdc), Orphan Drug (rcdc), Lung (rcdc), Rare Diseases (rcdc), 5.1 Pharmaceuticals (hrcs-rac), 2.1 Biological and endogenous factors (hrcs-rac), Respiratory (hrcs-hc), Animals (mesh), Piperidines (mesh), Flavonoids (mesh), Mice (mesh), Humans (mesh), Idiopathic Pulmonary Fibrosis (mesh), Cyclin-Dependent Kinase 9 (mesh), Drug Repositioning (mesh), Administration, Inhalation (mesh), Male (mesh), Fibroblasts (mesh), Lung (mesh), Disease Models, Animal (mesh), Cell Proliferation (mesh), Mice, Inbred C57BL (mesh), Indoles (mesh), Bleomycin (mesh), Protein Kinase Inhibitors (mesh), CDK9, Flavopiridol, Inhaled drugs, Fibroblasts, Lung fibrosis, Lung (mesh), Fibroblasts (mesh), Animals (mesh), Mice, Inbred C57BL (mesh), Humans (mesh), Mice (mesh), Disease Models, Animal (mesh), Piperidines (mesh), Flavonoids (mesh), Indoles (mesh), Bleomycin (mesh), Protein Kinase Inhibitors (mesh), Administration, Inhalation (mesh), Cell Proliferation (mesh), Male (mesh), Cyclin-Dependent Kinase 9 (mesh), Idiopathic Pulmonary Fibrosis (mesh), Drug Repositioning (mesh), CDK9, Fibroblasts, Flavopiridol, Inhaled drugs, Lung fibrosis, Animals (mesh), Piperidines (mesh), Flavonoids (mesh), Mice (mesh), Humans (mesh), Idiopathic Pulmonary Fibrosis (mesh), Cyclin-Dependent Kinase 9 (mesh), Drug Repositioning (mesh), Administration, Inhalation (mesh), Male (mesh), Fibroblasts (mesh), Lung (mesh), Disease Models, Animal (mesh), Cell Proliferation (mesh), Mice, Inbred C57BL (mesh), Indoles (mesh), Bleomycin (mesh), Protein Kinase Inhibitors (mesh), 0801 Artificial Intelligence and Image Processing (for), 1115 Pharmacology and Pharmaceutical Sciences (for), 1701 Psychology (for), 1702 Cognitive Sciences (for), Behavioral Science & Comparative Psychology (science-metrix), Pharmacology & Pharmacy (science-metrix), 3109 Zoology (for-2020), 3214 Pharmacology and pharmaceutical sciences (for-2020), 5204 Cognitive and computational psychology (for-2020), 5205 Social and personality psychology (for-2020)

Prístupová URL adresa: https://escholarship.org/uc/item/2h70n9h3

Synthesis and Structure–Activity Relationships of CRBN-Recruiting ZBTB11 Molecular Glue Degraders

Autori: Jiang, Jiewei Tran, Nathan L Svendsen, Emma a ďalší

Zdroj: Journal of Medicinal Chemistry. 68(18)

Predmety: 3404 Medicinal and Biomolecular Chemistry (for-2020), 34 Chemical Sciences (for-2020), Genetics (rcdc), Cancer (rcdc), Biotechnology (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Humans (mesh), Structure-Activity Relationship (mesh), Cell Line, Tumor (mesh), Cell Proliferation (mesh), Antineoplastic Agents (mesh), Proteolysis (mesh), Repressor Proteins (mesh), Ubiquitin-Protein Ligases (mesh), Cell Line, Tumor (mesh), Humans (mesh), Ubiquitin-Protein Ligases (mesh), Repressor Proteins (mesh), Antineoplastic Agents (mesh), Cell Proliferation (mesh), Structure-Activity Relationship (mesh), Proteolysis (mesh), Humans (mesh), Structure-Activity Relationship (mesh), Cell Line, Tumor (mesh), Cell Proliferation (mesh), Antineoplastic Agents (mesh), Proteolysis (mesh), Repressor Proteins (mesh), Ubiquitin-Protein Ligases (mesh), 0304 Medicinal and Biomolecular Chemistry (for), 0305 Organic Chemistry (for), 1115 Pharmacology and Pharmaceutical Sciences (for), Medicinal & Biomolecular Chemistry (science-metrix), 3214 Pharmacology and pharmaceutical sciences (for-2020), 3404 Medicinal and biomolecular chemistry (for-2020), 3405 Organic chemistry (for-2020)

Prístupová URL adresa: https://escholarship.org/uc/item/689030kw

Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells

Autori: Serafini, Marta Twigger, Sophie A Delfas, George a ďalší

Zdroj: Journal of the American Chemical Society

Predmety: 3404 Medicinal and Biomolecular Chemistry (for-2020), 34 Chemical Sciences (for-2020), Cancer (rcdc), Biotechnology (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), 03 Chemical Sciences (for), General Chemistry (science-metrix), 34 Chemical sciences (for-2020), 40 Engineering (for-2020)

Prístupová URL adresa: https://escholarship.org/uc/item/0kd314g3

A Synthetic Phage-Peptide Conjugate as a Potent Antibacterial Agent for Pseudomonas aeruginosa Infections

Autori: Yang, Yanxi Vexler, Shelby Jordan, Maria C a ďalší

Zdroj: ACS Central Science. 11(9)

Predmety: 34 Chemical Sciences (for-2020), Biotechnology (rcdc), Biodefense (rcdc), Infectious Diseases (rcdc), Emerging Infectious Diseases (rcdc), Antimicrobial Resistance (rcdc), Pneumonia (rcdc), Lung (rcdc), Pneumonia & Influenza (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Infection (hrcs-hc), 3 Good Health and Well Being (sdg), 03 Chemical Sciences (for), 34 Chemical sciences (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/0k4350sq
https://escholarship.org/content/qt0k4350sq/qt0k4350sq.pdf

USP10/GSK3B-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer

Autori: Kumari, Nishi Wright, Sarah CE Witham, Christopher M a ďalší

Zdroj: Journal of Clinical Investigation

Predmety: 31 Biological Sciences (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Women's Health (rcdc), Breast Cancer (rcdc), Genetics (rcdc), Cancer (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Breast cancer, Cell biology, Oncology, Signal transduction, Ubiquitin-proteosome system, 11 Medical and Health Sciences (for), Immunology (science-metrix), 31 Biological sciences (for-2020), 32 Biomedical and clinical sciences (for-2020), 42 Health sciences (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/5040q3cg
https://escholarship.org/content/qt5040q3cg/qt5040q3cg.pdf

Microbial biotherapeutic metabolite alleviates liver injury by restoring hepatic lipid metabolism through PPARα across the gut-liver axis

Autori: Kramer, Dylan J Wang, Weicang Loque, Ikaika a ďalší

Zdroj: mBio. 16(9)

Predmety: 3101 Biochemistry and Cell Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 31 Biological Sciences (for-2020), Infectious Diseases (rcdc), Digestive Diseases (rcdc), Microbiome (rcdc), Liver Disease (rcdc), Biotechnology (rcdc), Orphan Drug (rcdc), Nutrition (rcdc), Regenerative Medicine (rcdc), Rare Diseases (rcdc), Chronic Liver Disease and Cirrhosis (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 5.1 Pharmaceuticals (hrcs-rac), 1.1 Normal biological development and functioning (hrcs-rac), Infection (hrcs-hc), Oral and gastrointestinal (hrcs-hc), 3 Good Health and Well Being (sdg), PPAR alpha (mesh), Animals (mesh), Lipid Metabolism (mesh), Liver (mesh), Gastrointestinal Microbiome (mesh), Mice (mesh), Male (mesh), Mice, Inbred C57BL (mesh), Disease Models, Animal (mesh), Dysbiosis (mesh), Liver Regeneration (mesh), Intestinal Mucosa (mesh), NAFLD, gut-liver axis, microbial metabolite, biotherapeutic, 10-hydroxystearic acid, Intestinal Mucosa (mesh), Liver (mesh), Animals (mesh), Mice, Inbred C57BL (mesh), Mice (mesh), Disease Models, Animal (mesh), PPAR alpha (mesh), Liver Regeneration (mesh), Male (mesh), Lipid Metabolism (mesh), Dysbiosis (mesh), Gastrointestinal Microbiome (mesh), 10-hydroxystearic acid, NAFLD, biotherapeutic, gut-liver axis, microbial metabolite, PPAR alpha (mesh), Animals (mesh), Lipid Metabolism (mesh), Liver (mesh), Gastrointestinal Microbiome (mesh), Mice (mesh), Male (mesh), Mice, Inbred C57BL (mesh), Disease Models, Animal (mesh), Dysbiosis (mesh), Liver Regeneration (mesh), Intestinal Mucosa (mesh), 0605 Microbiology (for), 3101 Biochemistry and cell biology (for-2020), 3107 Microbiology (for-2020), 3207 Medical microbiology (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/80n8n8f7
https://escholarship.org/content/qt80n8n8f7/qt80n8n8f7.pdf

Computational design of potent and selective binders of BAK and BAX

Autori: Berger, Stephanie Lee, Erinna F Harris, Tiffany J a ďalší

Zdroj: Science Advances. 11(36)

Predmety: 3101 Biochemistry and Cell Biology (for-2020), 31 Biological Sciences (for-2020), Biotechnology (rcdc), 5.1 Pharmaceuticals (hrcs-rac), bcl-2 Homologous Antagonist-Killer Protein (mesh), bcl-2-Associated X Protein (mesh), Humans (mesh), Apoptosis (mesh), Protein Binding (mesh), Models, Molecular (mesh), Humans (mesh), Apoptosis (mesh), Protein Binding (mesh), Models, Molecular (mesh), bcl-2 Homologous Antagonist-Killer Protein (mesh), bcl-2-Associated X Protein (mesh), bcl-2 Homologous Antagonist-Killer Protein (mesh), bcl-2-Associated X Protein (mesh), Humans (mesh), Apoptosis (mesh), Protein Binding (mesh), Models, Molecular (mesh)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/78w4d6s8
https://escholarship.org/content/qt78w4d6s8/qt78w4d6s8.pdf

Lysine-Targeting Inhibitors of Amyloidogenic Protein Aggregation: A Promise for Neurodegenerative Proteinopathies

Autori: Murakami, Kazuma Van Nguyen, Thi Hong Nagao, Chioko a ďalší

Zdroj: JACS Au. 5(8)

Predmety: 3404 Medicinal and Biomolecular Chemistry (for-2020), 34 Chemical Sciences (for-2020), Neurosciences (rcdc), Neurodegenerative (rcdc), Aging (rcdc), Brain Disorders (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Neurological (hrcs-hc), amyloid, Alzheimer's disease, Parkinson'sdisease, tauopathy, covalent drug, post-translationalmodification, NMR, mass spectrometry, Alzheimer’s disease, NMR, Parkinson’s disease, amyloid, covalent drug, mass spectrometry, post-translational modification, tauopathy, 34 Chemical sciences (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/2n44525k
https://escholarship.org/content/qt2n44525k/qt2n44525k.pdf

Genetic variation in the activity of a TREM2–p53 signaling axis determines oxygen-induced lung injury

Autori: Abe, Yohei Spann, Nathanael J Tang, Wenxi a ďalší

Zdroj: Nature Immunology. 26(8)

Predmety: 3213 Paediatrics (for-2020), 32 Biomedical and Clinical Sciences (for-2020), Pediatric (rcdc), Lung (rcdc), Rare Diseases (rcdc), Preterm, Low Birth Weight and Health of the Newborn (rcdc), Prevention (rcdc), Neonatal Respiratory Distress (rcdc), Orphan Drug (rcdc), Perinatal Period - Conditions Originating in Perinatal Period (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 5.1 Pharmaceuticals (hrcs-rac), Animals (mesh), Signal Transduction (mesh), Receptors, Immunologic (mesh), Mice (mesh), Hyperoxia (mesh), Membrane Glycoproteins (mesh), Mice, Inbred C57BL (mesh), Tumor Suppressor Protein p53 (mesh), Bronchopulmonary Dysplasia (mesh), Oxygen (mesh), Lung Injury (mesh), Mice, Knockout (mesh), Humans (mesh), Disease Models, Animal (mesh), Genetic Variation (mesh), Lung (mesh), Immunity, Innate (mesh), Animals, Newborn (mesh), Lung (mesh), Animals (mesh), Mice, Inbred C57BL (mesh), Animals, Newborn (mesh), Mice, Knockout (mesh), Humans (mesh), Mice (mesh), Bronchopulmonary Dysplasia (mesh), Disease Models, Animal (mesh), Hyperoxia (mesh), Oxygen (mesh), Membrane Glycoproteins (mesh), Receptors, Immunologic (mesh), Signal Transduction (mesh), Tumor Suppressor Protein p53 (mesh), Immunity, Innate (mesh), Genetic Variation (mesh), Lung Injury (mesh), Animals (mesh), Signal Transduction (mesh), Receptors, Immunologic (mesh), Mice (mesh), Hyperoxia (mesh), Membrane Glycoproteins (mesh), Mice, Inbred C57BL (mesh), Tumor Suppressor Protein p53 (mesh), Bronchopulmonary Dysplasia (mesh), Oxygen (mesh), Lung Injury (mesh), Mice, Knockout (mesh), Humans (mesh), Disease Models, Animal (mesh), Genetic Variation (mesh), Lung (mesh), Immunity, Innate (mesh), Animals, Newborn (mesh), 1107 Immunology (for), Immunology (science-metrix), 3101 Biochemistry and cell biology (for-2020), 3204 Immunology (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/22582970
https://escholarship.org/content/qt22582970/qt22582970.pdf

Remote‐Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model

Autori: Li, Houpu Asefifeyzabadi, Narges Schorger, Kaelan a ďalší

Zdroj: Advanced Materials Technologies. 10(16)

Predmety: 40 Engineering (for-2020), 4003 Biomedical Engineering (for-2020), Bioengineering (rcdc), Wound Healing and Care (rcdc), 5.1 Pharmaceuticals (hrcs-rac), bioelectronics, precision medicine, wound healing, bioelectronics, precision medicine, wound healing, 34 Chemical sciences (for-2020), 40 Engineering (for-2020), 51 Physical sciences (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/7fx4b64k
https://escholarship.org/content/qt7fx4b64k/qt7fx4b64k.pdf

Exogenous thyroxine increases cardiac Nrf2-TRX and reduces oxidative injury in insulin-resistant male OLETF rats.

Autori: Mendez, Dora A García, Jenifer Hernández Soñanez-Organis, José G a ďalší

Zdroj: Journal of Endocrinology. 266(2)

Predmety: 32 Biomedical and Clinical Sciences (for-2020), 3202 Clinical Sciences (for-2020), Heart Disease (rcdc), Genetics (rcdc), Nutrition (rcdc), Diabetes (rcdc), Cardiovascular (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 5.1 Pharmaceuticals (hrcs-rac), Cardiovascular (hrcs-hc), Animals (mesh), NF-E2-Related Factor 2 (mesh), Thyroxine (mesh), Male (mesh), Insulin Resistance (mesh), Oxidative Stress (mesh), Rats (mesh), Thioredoxins (mesh), Myocardium (mesh), Rats, Inbred OLETF (mesh), Diabetes Mellitus, Type 2 (mesh), Myocardium (mesh), Animals (mesh), Rats, Inbred OLETF (mesh), Rats (mesh), Diabetes Mellitus, Type 2 (mesh), Insulin Resistance (mesh), Thyroxine (mesh), Oxidative Stress (mesh), Male (mesh), NF-E2-Related Factor 2 (mesh), Thioredoxins (mesh), T2DM, antioxidants, cardiovascular disease, metabolic syndrome, redox, Animals (mesh), NF-E2-Related Factor 2 (mesh), Thyroxine (mesh), Male (mesh), Insulin Resistance (mesh), Oxidative Stress (mesh), Rats (mesh), Thioredoxins (mesh), Myocardium (mesh), Rats, Inbred OLETF (mesh), Diabetes Mellitus, Type 2 (mesh), 0702 Animal Production (for), 0707 Veterinary Sciences (for), 1103 Clinical Sciences (for), Endocrinology & Metabolism (science-metrix), 3003 Animal production (for-2020), 3202 Clinical sciences (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/8w6705tq
https://escholarship.org/content/qt8w6705tq/qt8w6705tq.pdf

Safety and efficacy of a STAT3-targeted cyclic oligonucleotide: From murine models to a phase 1 clinical trial in pet cats with oral cancer

Autori: Grandis, Jennifer R Skorupski, Katherine A Cheng, Ning a ďalší

Zdroj: Cancer Cell. 43(11)

Predmety: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), 3204 Immunology (for-2020), Digestive Diseases (rcdc), Rare Diseases (rcdc), Clinical Research (rcdc), Clinical Trials and Supportive Activities (rcdc), Orphan Drug (rcdc), Cancer (rcdc), Dental/Oral and Craniofacial Disease (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Animals (mesh), Cats (mesh), Humans (mesh), Mice (mesh), Mouth Neoplasms (mesh), Disease Models, Animal (mesh), Oligonucleotides (mesh), Female (mesh), Male (mesh), STAT3 Transcription Factor (mesh), Squamous Cell Carcinoma of Head and Neck (mesh), STAT3, STAT3 inhibitor, clinical trial, cyclic STAT3 decoy, feline oral cancer, head and neck cancer, oral cancer, Animals (mesh), STAT3 Transcription Factor (mesh), Cats (mesh), Mice (mesh), Mouth Neoplasms (mesh), Female (mesh), Disease Models, Animal (mesh), Humans (mesh), Male (mesh), Squamous Cell Carcinoma of Head and Neck (mesh), Oligonucleotides (mesh), 1109 Neurosciences (for), 1112 Oncology and Carcinogenesis (for), Oncology & Carcinogenesis (science-metrix), 3101 Biochemistry and cell biology (for-2020), 3211 Oncology and carcinogenesis (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/4bk0p3wt
https://escholarship.org/content/qt4bk0p3wt/qt4bk0p3wt.pdf

Genetic and pharmacological targeting of nicotinic acetylcholine receptor action blocks tumor progression in mouse models of breast cancer

Autori: Heard, Matthew A Qian, Jin Sayeed, Sakeef a ďalší

Zdroj: The Journal of Immunology. 214(8)

Predmety: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), 3204 Immunology (for-2020), Biotechnology (rcdc), Women's Health (rcdc), Breast Cancer (rcdc), Immunotherapy (rcdc), Cancer (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Animals (mesh), Mice (mesh), Female (mesh), alpha7 Nicotinic Acetylcholine Receptor (mesh), Mice, Knockout (mesh), Disease Models, Animal (mesh), Cell Line, Tumor (mesh), Humans (mesh), Breast Neoplasms (mesh), Disease Progression (mesh), Mammary Neoplasms, Experimental (mesh), CD8-Positive T-Lymphocytes (mesh), Dendritic Cells (mesh), nicotinic acetycholine receptor, dendritic cells, triple negative breast cancer, immunotherapeutics, metastasis, Dendritic Cells (mesh), CD8-Positive T-Lymphocytes (mesh), Cell Line, Tumor (mesh), Animals (mesh), Mice, Knockout (mesh), Humans (mesh), Mice (mesh), Breast Neoplasms (mesh), Mammary Neoplasms, Experimental (mesh), Disease Models, Animal (mesh), Disease Progression (mesh), Female (mesh), alpha7 Nicotinic Acetylcholine Receptor (mesh), dendritic cells, immunotherapeutics, metastasis, nicotinic acetycholine receptor, triple negative breast cancer, Animals (mesh), Mice (mesh), Female (mesh), alpha7 Nicotinic Acetylcholine Receptor (mesh), Mice, Knockout (mesh), Disease Models, Animal (mesh), Cell Line, Tumor (mesh), Humans (mesh), Breast Neoplasms (mesh), Disease Progression (mesh), Mammary Neoplasms, Experimental (mesh), CD8-Positive T-Lymphocytes (mesh), Dendritic Cells (mesh), 1107 Immunology (for), Immunology (science-metrix), 3101 Biochemistry and cell biology (for-2020), 3204 Immunology (for-2020)

Prístupová URL adresa: https://escholarship.org/uc/item/5fr2h9w6

Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy

Autori: Lin, Katie Zou, Christopher Hubbard, Akane a ďalší

Zdroj: Neuro-Oncology. 27(6)

Predmety: 32 Biomedical and Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Gene Therapy (rcdc), Bioengineering (rcdc), Orphan Drug (rcdc), Cancer (rcdc), Genetics (rcdc), Brain Disorders (rcdc), Neurosciences (rcdc), Nanotechnology (rcdc), Rare Diseases (rcdc), Human Genome (rcdc), Biotechnology (rcdc), Brain Cancer (rcdc), 5.1 Pharmaceuticals (hrcs-rac), Cancer (hrcs-hc), Glioblastoma (mesh), Humans (mesh), Animals (mesh), Brain Neoplasms (mesh), Mice (mesh), Epigenesis, Genetic (mesh), Temozolomide (mesh), Xenograft Model Antitumor Assays (mesh), Gene Editing (mesh), Lomustine (mesh), Tumor Cells, Cultured (mesh), Drug Resistance, Neoplasm (mesh), DNA Repair Enzymes (mesh), CRISPR-Cas Systems (mesh), Tumor Suppressor Proteins (mesh), DNA Modification Methylases (mesh), Mice, Nude (mesh), Epigenetic Memory (mesh), CRISPR, CCNU, epigenetic editing, glioblastoma, temozolomide, Tumor Cells, Cultured (mesh), Animals (mesh), Humans (mesh), Mice (mesh), Mice, Nude (mesh), Glioblastoma (mesh), Brain Neoplasms (mesh), Lomustine (mesh), DNA Repair Enzymes (mesh), DNA Modification Methylases (mesh), Tumor Suppressor Proteins (mesh), Xenograft Model Antitumor Assays (mesh), Epigenesis, Genetic (mesh), Drug Resistance, Neoplasm (mesh), CRISPR-Cas Systems (mesh), Gene Editing (mesh), Temozolomide (mesh), Epigenetic Memory (mesh), CCNU, CRISPR, epigenetic editing, glioblastoma, temozolomide, Glioblastoma (mesh), Humans (mesh), Animals (mesh), Brain Neoplasms (mesh), Mice (mesh), Epigenesis, Genetic (mesh), Temozolomide (mesh), Xenograft Model Antitumor Assays (mesh), Gene Editing (mesh), Lomustine (mesh), Tumor Cells, Cultured (mesh), Drug Resistance, Neoplasm (mesh), DNA Repair Enzymes (mesh), CRISPR-Cas Systems (mesh), Tumor Suppressor Proteins (mesh), DNA Modification Methylases (mesh), Mice, Nude (mesh), Epigenetic Memory (mesh), 1109 Neurosciences (for), 1112 Oncology and Carcinogenesis (for), Oncology & Carcinogenesis (science-metrix), 3211 Oncology and carcinogenesis (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/5n7670tz
https://escholarship.org/content/qt5n7670tz/qt5n7670tz.pdf

Mutation of an active site-adjacent residue in VIM indirectly dictates interactions with and blunts inhibition by D-captopril

Autori: Silwal, Surendra Bikram Wamsley, Bode Wang, Zongyao a ďalší

Zdroj: Journal of Inorganic Biochemistry. 271

Predmety: 3402 Inorganic Chemistry (for-2020), 34 Chemical Sciences (for-2020), 5.1 Pharmaceuticals (hrcs-rac), Catalytic Domain (mesh), Captopril (mesh), beta-Lactamases (mesh), Crystallography, X-Ray (mesh), Mutation (mesh), beta-Lactamase Inhibitors (mesh), Escherichia coli (mesh), Escherichia coli (mesh), beta-Lactamases (mesh), Captopril (mesh), Crystallography, X-Ray (mesh), Catalytic Domain (mesh), Mutation (mesh), beta-Lactamase Inhibitors (mesh), Antibiotic resistance, Enzyme inhibition, Metallo-β-lactamase, Protein crystallography, Catalytic Domain (mesh), Captopril (mesh), beta-Lactamases (mesh), Crystallography, X-Ray (mesh), Mutation (mesh), beta-Lactamase Inhibitors (mesh), Escherichia coli (mesh), 0302 Inorganic Chemistry (for), 0307 Theoretical and Computational Chemistry (for), 0399 Other Chemical Sciences (for), Inorganic & Nuclear Chemistry (science-metrix), 3402 Inorganic chemistry (for-2020)

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/4hb1m07p
https://escholarship.org/content/qt4hb1m07p/qt4hb1m07p.pdf